Khoom Taw qhia
| Protocechualdehyde Cov ntaub ntawv yooj yim |
| Khoom npe: | Protocatechualdehyde |
| Synonyms: | AURORA 17180;AKOS BBS-00003254;3,4-DIHYDROXYBENZALDEHYDE;4-FORMYL-1,2-DIHYDROXYBENZENE;PROTOCATECHUALDEHYDE;PROTOCATECHUIC{8}ALDE; }Dihydroxy-4-formylbenzene; 3,{11}}dihydroxy-benzaldehyd |
| CAS: | 139-85-5 |
| MF: | C7H6O3 |
| MW: | 138.12 |
| EINECS: | 205-377-7 |
| Khoom Categories: | tshuaj reagent; tshuaj nruab nrab; tshuaj ntsuab extract; phytochemical; siv cov qauv los ntawm Suav tshuaj ntsuab (TCM); standardized herbal extract; FINE Chemical & INTERMEDIATES; Aromatic Aldehydes & Derivatives (substituted); BenzaldehydeDerivative; 1Benzaldehyde; 0; 0. ;139-85-5 |
| Mol File: | 139-85-5.mol |
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| Protocechualdehyde Cov Khoom Siv Tshuaj |
| Melting point | 150-157 degree (lit.) |
| Boiling point | 213.5 degree (kev kwv yees kwv yees) |
| ceev | 1.2667 (kev kwv yees kwv yees) |
| Refractive Index | 1.4600 (kwv yees) |
| cia temp. | Khaws hauv qab +30 degree . |
| solubility | 6.3g/l |
| daim ntawv | Crystalline hmoov |
| pka ua | PK (25 degree) 7.55 |
| xim | me ntsis xim av |
| tsw | ntawm 100.00%. qhuav tshuaj iab almond |
| Hom tshuaj tsw qab | tshuaj |
| Dej Solubility | 50 g/L (20 ºC) |
| rhiab heev | Huab cua Sensitive |
| Merck | 14,7893 |
| BRN | 774381 |
| Kev ruaj ntseg: | ruaj khov. Incompatible nrog cov hauv paus muaj zog, muaj zog oxidizing tus neeg sawv cev. |
| LogP | 1.090 |
| CAS DataBase Reference | 139-85-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 3, 4-Dihydroxybenzaldehyde (139-85-5) |
| EPA Tshuaj Registry System | Benzaldehyde, 3, 4-dihydroxy- (139-85-5) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-22 |
| Cov lus hais txog kev nyab xeeb | 26-36-37/39 |
| WGK Germany | 3 |
| RTECS | UL 0380000 |
| F | 9 |
| Ceeb toom | Irritant/Air Sensitive |
| HS Code | 29124900 |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| Protocatechualdehyde | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| Protocechualdehyde Siv thiab Synthesis |
| Kev piav qhia | Protocechualdehyde yog muab rho tawm los ntawm cov hauv paus hniav ntawm cov tshuaj suav tshuaj suav tshuaj Salvia miltiorrhiza Bge, uas tau sau rau lub caij nplooj zeeg kom zoo dua. Siv cov hauv paus thiab tshem tawm stems, nplooj thiab fibrous keeb kwm, ces qhuav nws. Lawv feem ntau yog dav, thiab lawv tau cog qoob loo hauv xyoo tas los no. South Salvia thiab Gansu Salvia kuj tau siv dav. Tsis tas li ntawd, muaj ntau yam ntawm cov nus muag cov hauv paus hniav siv los ua Salvia miltiorrhiza hauv Yunnan. Tam sim no, lub hav zoov ntawm protocatechualdehyde tau pom nyob rau hauv ntau yam tshuaj ntsuab, piv txwv li, nyob rau hauv nplooj ntawm Stenoloma Chusanum (L.) Ching thiab Ilex chinensis Sims. |
| Chemical Properties | Protocechualdehyde yog phenolic aldehyde crystalline compound nrog cov mis mos molecular C7H6O3. Lub compound yog tso tawm los ntawm cork stoppers rau hauv cawv. protocatechualdehyde tuaj yeem pom nyob rau hauv barley, grapevine, ntsuab Cavendish, thiab hauv paus ntawm tshuaj ntsuab S. miltiorrhiza. Cov tshuaj muaj cov pro-apoptotic thiab antiproliferative zog tiv thaiv tib neeg cov qog nqaij hlav cancer mis nrog rau cov qog nqaij hlav hauv plab los ntawm kev txo cov kev qhia ntawm cyclin D1 thiab -catenin. |
| Lub cev muaj zog | Cov tsos mob: daj ntseg beige acicular siv lead ua (hauv dej los yog methylbenzene) los yog cov hmoov dawb dawb, siv lead ua ntxaib. Solubility: yooj yim soluble hauv ethanol, acetone, ethyl acetate, ethyl ether, thiab dej kub; soluble nyob rau hauv dej txias; insoluble hauv benzene thiab chloroform. Melting point: 150-153? degree. Kev sib hloov kho qhov muag tshwj xeeb: yooj yim oxidized rau benzoquinone thiab hloov xim, thiab nws tsis ruaj khov hauv dej. |
| Keeb kwm | Hauv xyoo 1940, kev tshawb fawb tau tshawb fawb txawv teb chaws kom tau txais cov tshuaj protocechualdehyde. Nyob rau hauv 1972, pawg tshuaj ntawm Suav tshuaj ntsuab tshuaj nyob rau hauv Nanjing College ntawm Pharmacy systematically kawm tshuaj muaj pes tsawg leeg nyob rau hauv liab doog paj holly nplooj thiab cais rau monomers nrog rau protocechualdehyde. Tom qab ntawd lawv muab piv rau cov nyhuv ntawm protocechualdehyde, Salvia miltiorrhiza txhaj thiab plaub hau holly cag txhaj, nyob rau hauv uas protocechualdehyde yog qhov zoo tshaj plaws nyob rau hauv kev ua kom coronary sinus flow. Cov kev sim ntxiv tau tshuaj xyuas tias protocechualdehyde tuaj yeem ua rau cov hlab ntsha ntws thiab txhim kho cov hlab ntsha, yog li nws raug hu ua tom qab perhexiline. Kev soj ntsuam ntxiv qhia tau hais tias protocechualdehyde cuam tshuam rau kab mob plawv. Cov kawm tiav ntawm Nanjing College of Pharmacy hauv 1975 tau muab rho tawm, sib cais, cais, thiab txheeb xyuas cov protocechualdehyde hauv Salviamiltiorrhiza thaum lub sijhawm ua haujlwm hauv Nanjing Municipal Tsev Kho Mob thiab kawm txog nws qhov kev faib tawm, tshem tawm, thiab tshuaj lom hauv cov tsiaj rau kev siv tshuaj kho mob. |
| Siv | 3,4-Dihydroxybenzaldehyde yog siv los ua apoptosis inducer ntawm tib neeg leukemia hlwb. |
| Siv | 3,4-Dihydroxybenzaldehyde tuaj yeem siv rau kev hloov kho saum npoo ntawm nanocrystalline TiO2cov khoom. Electrodeposited txheej ntawm 3,4-dihydroxybenzaldehyde tuaj yeem siv los ua tus neeg nruab nrab redox zoo thaum oxidation ntawm NADH ntawm graphene. Nws tuaj yeem siv rau hauv kev npaj cov tshiab diSchiff puag ligands, uas ua rau di-, tri- thiab tetranuclear Co(II) thiab Cu(II) complexes. |
| Txhais | ChEBI: 3, 4-dihydroxybenzaldehyde yog dihydroxybenzaldehyde. |
| Synthesis Reference (cov) | Phau ntawv Journal of Organic Chemistry, 27, p. Xyoo 2037, 1962DOI:10.1021/j01053a030 |
| Kev piav qhia dav dav | 3,4-Dihydroxybenzaldehyde tau lees paub tias yog ib qho ntawm cov tshuaj tua kab mob uas tau muab rho tawm los ntawm cov tawv nqaij sab nraud ntawm cov txiv tsawb ntsuab. Nws tuaj yeem raug tsim los ntawm catechol ntawm Fries rearrangement. |
| Pharmacology | Kev tiv thaiv ntawm?Myocardial Cells thiab?Myocardial Ischemia Txo Ca2+ concentration nyob rau hauv cov neeg laus erythrocyte cytosolic los tiv thaiv myocardium, dilating lub coronary arteriae, txhawb collateral ncig, ua rau myocardial oxygen mov coronary ntshav txaus, txhim kho collateral ncig yam tsis tau nce lub ventricular thiab myocardial oxygen noj, txo lub plawv dhia, inhibiting myocardial contractility, expanding peripheral vascular, thiab thaum kawg txo cov plawv load thiab myocardial oxygen noj. Siv rau kev kho mob ntawm cov kab mob plawv thiab angina pectoris. Cov teebmeem ntawm?Atherosclerosis Protocechualdehyde txhim kho atherosclerosis los ntawm cov nyhuv ntawm inhibition ntawm o, apoptosis, thiab leukocyte chemotaxis. Cov teebmeem Antithrombotic 1. Platelet aggregation inhibition: Kev tswj hwm ntawm protocatechualdehyde in?vitro thiab in?vivo tau pom zoo cuam tshuam rau inhibiting platelet aggregation induced los ntawm ADP. qeeb tus nqi ntawm platelet aggregation thiab txhawb kev sib sau ntawm platelet. 2. Txhim kho microcirculation: Protocechualdehyde tuaj yeem ua kom cov ntshav ntws ntawm microcirculation, ua kom cov ntshav ntws los txhim kho cov pa oxygen ntawm cov hlwb, thiab txo cov qe ntshav liab ib txwm mus rau cov hlwb liab liab thiab qhov txawv txav ntawm spiny liab hlwb. Cov teebmeem Antioxidation Protocechualdehyde muaj phenolic hydroxyl nyob rau hauv ortho-txoj hauj lwm, uas yog cov khoom siv rau nws cov tshuaj tiv thaiv oxidation. Nws muaj cov haujlwm zoo rau kev tshem tawm cov dawb radicals. Yog li nws kho cov kab mob plawv thiab cerebrovascular induced los ntawm active oxygen. Tiv thaiv?Nerve Cells thiab?Cerebral Ischemia Injury Kev tiv thaiv ntawm cerebral ischemia raug mob tej zaum yuav muaj kev txhawj xeeb txog kev txo qis ntawm TXA2? nyob rau hauv cov ntaub so ntswg hlwb, inhibiting kev tso tawm ntawm excitatory amino acids nyob rau hauv lub hlwb cov ntaub so ntswg, thiab txhim kho cov microcirculation ntawm lub hlwb cov ntaub so ntswg. Kho ntawm?Damaged Venous Valve thiab?Kev kho ntawm?Phlebeurysm Protocatechualdehyde txo cov fibrosis ntawm cov ntaub so ntswg thiab cov kab mob hauv lub cev kom zoo, yaj fibrin, txhawb kev tsim kho ntawm fibrotic hlwb, thiab kho cov venous li qub kom tsis txhob ntws rov qab ntawm cov ntshav thiab kho phlebeurysm zoo. Lwm yam teebmeem Tiv thaiv daim siab thiab txhawb kev kho thiab rov tsim dua tshiab ntawm daim siab; antifibrosis ntawm daim siab thiab txhawb kev kho ntawm pob txha thiab qhov txhab; antibacterial, anti-inflammatory, antiviral, anti-sepsis, thiab tiv thaiv pigmentation. |
| Kev siv tshuaj kho mob | Perhexiline txhaj tshuaj muaj protocechualdehyde 100? mg/2? mL los ntawm kev txhaj tshuaj intravenous lossis intramuscular txhaj yog siv los kho cov kab mob plawv, mob hauv siab, angina, thiab myocardial infarction. Kev txhaj tshuaj kho mob ischemic stroke thiab txhim kho cov tsos mob thiab cov tsos mob ntawm cov neeg mob. Kho kab mob siab ntev thiab mob cirrhosis ntxov: txo cov tsos mob, txhawb kev rov ua haujlwm ntawm daim siab, thiab hepatosplenomegaly. Nws tuaj yeem txhim kho cov ntshav rheology Performance index rau cov neeg mob uas mob hnyav heev ntawm cov kab mob pulmonary plawv. Kev kho mob peptic ulcer: ib qho txiaj ntsig. Lwm yam: nws muaj feem xyuam rau ntau yam kab mob xws li viral myocarditis, embolism ntawm central retinal artery, thromboangiitis obliterans, scleredema neonatorum, scleroderma, psoriasis, paj hlwb lag ntseg, thiab toxemia ntawm cev xeeb tub. |
| Enzyme inhibitor | Qhov no aldehyde (FW=138.12 g / mol), tseem hu ua 3, 4- dihydroxybenzaldehyde thiab 4-formylcatechol, yog soluble hauv dej (5 g / 100 mL ntawm 20 degree) thiab muaj pKa tus nqi ntawm 7.55 ntawm 25 degree. Protocechualdehyde induces apoptosis hauv cytotoxic T hlwb. Target(s): aldehyde oxidase; aldose reductase; b-carotene 15,15'-monooxygenase; mandelonitrile lyase; protocatechuate 3,4-dioxygenase; protocatechuate 4, 5- dioxygenase; tyrosinase, weakly inhibited, IC50=620 μM; thiab xanthine oxidase. |
| Txoj kev Purification | Crystallize lub aldehyde los ntawm dej los yog toluene thiab qhuav nws nyob rau hauv lub tshuab nqus tsev desiccator tshaj KOH pellets los yog shredded ciab raws. [Beilstein 8 IV 1762.] |
| Protocechualdehyde Npaj Cov Khoom Siv Thiab Cov Khoom Raw |
| Cov khoom siv raw | Phosphorus pentachloride |
| Cov khoom npaj | 4'-FORMYLBENZO-15-CROWN 5-ETHER-->Dihydrocaffeic acid-->3',4'-(DIOCTYLOXY)BENZALDEHYDE-->3',4'-(DIDECYLOXY)BENZALDEHYDE-->2,5-dibromo-3,4-dimethoxy-Benzaldehyde-->3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE-7-CARBALDEHYDE-->2,3-Dihydroxybenzaldehyde-->4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE-->1,4-BENZODIOXAN-6-CARBOXALDEHYDE-->3,4-Dibenzyloxybenzaldehyde-->4-Difluoromethoxy-3-hydroxybenzaldehyde |
Cim npe nrov: Tuam Tshoj protocatechualdehyde manufacturers, lwm tus neeg, Hoobkas
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