Khoom

Tsev / Khoom/ Tshuaj Reagents / Organic Reagents

4-Methylmorpholine

Khoom Taw qhia

4-Methylmorpholine Cov ntaub ntawv yooj yim

Khoom npe:	4-Methylmorpholine
Synonyms:	NMM;N-Methyl morphofine;N-METHYLMORPHOLINE;4-METHYL-1-OXA-4-AZACYCLOHEXANE;4-METHYLMORPHOLINE;AKOS 89985;LUPRAGEN(R) N 105;{{8} }}Methylmorpholine
CAS:	109-02-4
MF:	C5H11 Nr
MW:	101.15
EINECS:	203-640-0
Khoom Categories:	Tsev Blocks; Heterocyclic Building Blocks; Morpholines; Protein Sequencing; Protein Structural Analysis; Reagents for Protein Sequencing; Morpholines Essential Chemicals; Reagent Plus; Routine Reagents; Tsev Blocks; Chemical Synthesis; Proteins; Organic solvents; pholines ;109-02-4;bc0001
Mol File:	109-02-4.mol

4-Methylmorpholine Chemical Properties

Melting point	-66 degree (lit.)
Boiling point	115-116 degree 750 mm Hg (lit.)
ceev	0.92 g/mL ntawm 25 degree (lit.)
vapor ceev	>1 (vs huab cua)
vapor siab	18 hli Hg (20 degree)
Refractive Index	n20/D 1.435 (lit.)
Fp	75 degree F
cia temp.	Khaws hauv qab +30 degree .
solubility	Chloroform (Soluble), Ethyl Acetate, Methanol (me ntsis)
daim ntawv	Ua kua
pka ua	7.38 (ntawm 25 degree)
xim	Ntshiab
Specific Gravity	0.920 (20/4 degree)
PH	10.6 (50g / l, H2O, 20 degree)
tawg txwv	2.1%(V)
Dej Solubility	>500 g/L (20 ºC)
Merck	14,6277
BRN	102719
Kev ruaj ntseg:	Volatile
InChIKey	SJRJJKPEHAURKC-UHFFFAOYSA-N
LogP	-0.32 ntawm 25 degree
CAS DataBase Reference	109-02-4(CAS DataBase Reference)
NIST Chemistry Reference	Morpholine, 4-methyl-(109-02-4)
EPA Tshuaj Registry System	4-Methylmorpholine (109-02-4)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	F,C
Risk Statements	11-20/21/22-34-10-22
Cov lus hais txog kev nyab xeeb	16-26-36/37/39-45-25
RIDADR	UN 2535 3/PG 2
WGK Germany	1
RTECS	QE5775000
F	10-23
Autoignition Kub	165 degree DIN 51794
TSCA	Yog lawm
HazardClass	3
PackingGroup	II
HS Code	29349990
Toxicity	LD50 qhov ncauj hauv luav: 1960 mg/kg LD50 dermal Rabbit 1240 mg/kg

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
4-Methyl-1-oxa-4-azacyclohexane	Lus Askiv
ACROS	Lus Askiv
SigmaAldrich	Lus Askiv
ALFA	Lus Askiv

4-Kev Siv Methylmorpholine Thiab Synthesis

Chemical Properties	tsis muaj xim thiab pob tshab kua. nrog cov yam ntxwv tsw. Soluble nyob rau hauv cov kuab tshuaj organic, miscible nrog dej thiab ethanol.
Siv	4-Methylmorpholine yog cov kuab tshuaj zoo heev, emulsifier, corrosion inhibitor, Catalyst hauv polyurethane foamsextraction hnyav, stabilizing tus neeg sawv cev rau chlorinated hydrocarbons, thiab tseem tuaj yeem siv los ua tshuaj tua kab. 4-Methylmorpholine yog dav siv nyob rau hauv cov synthesis ntawm cov tshuaj tua kab xws li tshuaj tua kab, fungicide, cog kev loj hlob regulator, thiab lwm yam. Nws kuj yog siv nyob rau hauv lub synthesis ntawm zoo tshuaj xws li surfactant, lubricant coolant, hlau antirust agent, fiber ntau kho agent, lwm.
Siv	4-Methylmorpholine yog siv los ua ib qho hnyav rau dyes, resins, waxes thiab pharmaceuticals. Nws ua raws li tus crosslinker hauv kev npaj ntawm polyurethane foams, elastomers thiab adhesives. Nws yog siv los ua tus thawj coj los npaj N-methylmorpholine N-oxide thiab morpholinium cation raws li ionic kua. Nws yog siv los ua corrosion inhibitors thiab anti-scaling agents hauv kev lag luam.
Kev npaj	4-Methylmorpholine npaj txoj kev yog maj mam ntxiv formaldehyde hauv morpholine poob los ntawm kev poob, hauv qab nplawm ntxiv cov tshuaj tiv thaiv formic acid, tsis siv neeg reflux, thiab tso carbon dioxide. Tom qab ntxiv formic acid, cua sov reflux 4 ~ 5h, txias thiab ntxiv sodium hydroxide distillation tam sim ntawd, sau tag nrho cov feem ua ntej lub boiling point ntawm 99 degree, thiab ces ntxiv sodium hydroxide nyob rau hauv feem rau saturation, txias cov roj txheej, ziab, fractional. distillation, kom tau txais N-methylmorpholine.
Synthesis Reference (cov)	Tetrahedron Letters, 36, p. 4881 Ib., 1995DOI: 10.1016/0040-4039(95)00875-D
Kev piav qhia dav dav	Cov kua dej dawb nrog cov ntxhiab tsw zoo li ammonia. Tsawg dua dej thiab insoluble hauv dej. Flash point 75 degree F. Tej zaum yuav muaj mob me me los ntawm kev noj, nqus pa thiab nqus ntawm daim tawv nqaij. Heev irritating rau ntawm daim tawv nqaij, qhov muag, thiab mucous daim nyias nyias. Siv los ua cov kuab tshuaj thiab ua cov tshuaj.
Cua & Dej Reactions	Cov nplaim taws heev. Insoluble hauv dej.
Reactivity Profile	Amines yog cov khoom siv tshuaj. Lawv neutralize acids tsim cov ntsev ntxiv rau dej. Cov tshuaj tiv thaiv acid-base no yog exothermic. Tus nqi ntawm tshav kub uas hloov zuj zus mus rau ib mole ntawm amine nyob rau hauv ib tug neutralization yog feem ntau ywj siab ntawm lub zog ntawm amine raws li ib tug puag. Amines yuav tsis sib haum nrog isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, thiab acid halides. Flammable gaseous hydrogen yog tsim los ntawm amines ua ke nrog cov muaj zog txo cov neeg ua haujlwm, xws li hydrides.
Hazard	Flammable, phom sij txaus ntshai. Cov tawv nqaij irri-tant.
Health Hazard	Tej zaum yuav ua rau muaj tshuaj lom yog tias nqus tau los yog noj / nqos. Kev sib cuag nrog cov khoom yuav ua rau mob hnyav rau ntawm daim tawv nqaij thiab qhov muag. Hluav taws yuav ua rau khaus, corrosive thiab/los yog cov pa phem. Vapors tuaj yeem ua rau kiv taub hau lossis ua tsis taus pa. Cov dej ntws los ntawm kev tswj hluav taws kub lossis dej dilution tuaj yeem ua rau muaj kuab paug.
Hluav Taws Xob	Flammable / combustible khoom. Tej zaum yuav ignited los ntawm tshav kub, sparks los yog nplaim taws. Cov vapors tuaj yeem tsim cov khoom tawg nrog cua. Vapors tuaj yeem mus rau qhov chaw ntawm qhov hluav taws kub thiab rov qab flash. Feem ntau cov vapors hnyav dua li huab cua. Lawv yuav kis tau mus rau hauv av thiab sau rau hauv qhov chaw qis lossis qhov chaw kaw (sewers, hauv qab daus, tanks). Vapor explosion txaus ntshai nyob hauv tsev, sab nraum zoov lossis hauv cov kav dej. Cov dej ntws mus rau hauv cov kav dej yuav ua rau muaj hluav taws kub lossis tawg. Cov thawv ntim khoom tuaj yeem tawg thaum cua sov. Cov kua dej ntau yog sib dua li dej.
Flammability thiab Explosibility	Flamable
Kev ruaj ntseg Profile	Muaj tshuaj lom los ntawm kev noj tshuaj thiab kev sib cuag ntawm daim tawv nqaij. Mob me me los ntawm kev nqus pa. Ib qho irritant rau ntawm daim tawv nqaij, qhov muag, thiab mucous daim nyias nyias. Flammable thaum raug tshav kub los yog nplaim taws, tuaj yeem hnov mob nrog cov ntaub ntawv oxidizing. Thaum rhuab mus rau decomposition nws emits cov pa phem ntawm NOx.
Txoj Kev Purification	Qhuav nws los ntawm refluxing nrog BaO los yog sodium, ces fractionally distil nws los ntawm ib tug helices-packed kem. Lub picrate muaj m 227o, thiocyanate ntsev muaj m 103o (los ntawm butanone). [Hall J Phys Chem 60 63 1956, Beilstein 27 I 203, 27 III/IV 22.]

4-Methylmorpholine Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw

Cov khoom nyoos	Ammonia-->Formaldehyde-->Formic acid-->Methylamine-->Morpholine-->Diethylene glycol-->Glyoxylic acid-->2,2'-Dichlorodiethyl ether-->Ethanamine, N,N-dimethyl-2-[2-(methylamino)ethoxy]- -->4-Formylmorpholine-->4-Methylmorpholine N-oxide-->2-[2-(Dimethylamino)ethoxy]ethanol-->N-Methyldiethanolamine
Cov khoom npaj	1-Boc-4-(aminomethyl)piperidine-->3-Aminomethyl-1-N-Boc-piperidine-->3-Amino-5-fluoropyridine-->Azasetron hydrochloride-->Zafirlukast-->Cefpiramide acid-->Tenidap-->4-Methylmorpholine N-oxide monohydrate-->Fosinopril-->4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride-->Benazepril-->Alacepril-->1-Hydroxybenzotriazole hydrate

Cim npe nrov: 4-methylmorpholine, Tuam Tshoj 4-methylmorpholine manufacturers, lwm tus neeg, Hoobkas

Tug: 2-[2-(Dimethylamino)ethoxy]ethanol

Tom ntej: Cysteamine Hydrochloride

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