Khoom

Tsev / Khoom/ Tshuaj Reagents / Organic Reagents

Cysteamine Hydrochloride

Khoom Taw qhia

Cysteamine hydrochloride Cov ntaub ntawv yooj yim

Khoom npe:	Cysteamine hydrochloride
Synonyms:	mercaptoethylammonium chloride; Mercaptamine hydrochloride; DECARBOXYCYSTEINE HCL; DECARBOXYCYCYSTEINE HYDROCHLORIDE; CYSTEAMINIUM chloride; CYSTEAMINE HCL; CYSTEAMINE HYDROCHLORIDE; BETA-MERCAPTOE
CAS:	156-57-0
MF:	C2H8ClNS
MW:	113.61
EINECS:	205-858-1
Khoom Categories:	API intermediates; Antioxidant; Biochemistry; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; Pharmaceutical Intermediates; Sulfur compounds; Pib Raw Materials & Intermediates; Anilines, Aromatic Amines thiab Nitro Compounds; Proteinmodfereagent, tshuaj pleev ib ce, tshuaj pleev ib ce Inhibitors; 156-57-0
Mol File:	156-57-0.mol

Cysteamine hydrochloride Cov Khoom Siv Tshuaj

Melting point	67-71 degree
Boiling point	238.5 degree [ntawm 101 325 Pa]
ceev	0.75
vapor siab	5.333Pa ntawm 25 degree
Refractive Index	1.6100 (kwv yees)
cia temp.	2-8 degree
solubility	H₂O: 1 m ntawm 20 degree, ntshiab, tsis muaj xim
daim ntawv	Crystalline hmoov los yog pellets
xim	Dawb
PH	3. 3-5 {2}} (400g/l, H2O, 20 degree)
Dej Solubility	SOLUBLE heev
rhiab heev	Hygroscopic
lw max	λ: 280 nm Amax: Tsawg dua lossis sib npaug rau 0.3
Merck	14,2779
BRN	3590083
Kev ruaj ntseg:	Stable, tab sis hygroscopic. Incompatible nrog muaj zog oxidizing neeg sawv cev.
InChIKey	OGMADIBCHLQMIP-UHFFFAOYSA-N
LogP	-2.14 ntawm 25 degree
CAS DataBase Reference	156-57-0(CAS DataBase Reference)
EPA Tshuaj Registry System	Cysteamine hydrochloride (156-57-0)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	Xn, xis
Risk Statements	22-36/37/38
Cov lus hais txog kev nyab xeeb	36/37/39-26-36
RIDADR	TIAB SA 3335
WGK Germany	3
RTECS	KJ0200000
F	1-3-10-13
TSCA	Yog lawm
HS Code	29309070
Toxicity	LD50 qhov ncauj hauv Luav: 642 mg / kg

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
Cysteamine hydrochloride	Lus Askiv
ACROS	Lus Askiv
SigmaAldrich	Lus Askiv
ALFA	Lus Askiv

Cysteamine hydrochloride Siv thiab Synthesis

Kev piav qhia	Cysteamine yog ib qho aminothiol ruaj khov nrog cov dej num tiv thaiv kab mob. Nws txo cov ionizing hluav taws xob vim kev tuag thiab chromosomal puas hauv cov nas nyob rau hauv koob tshuaj. Cysteamine khi sai sai thiab ib ntus rau cov ntshav plasma proteins thaum tswj hwm thiab cov haujlwm no ncaj qha cuam tshuam rau nws cov teebmeem radioprotective.Hauv vitro, 0.1 mM cysteamine depletes 90% ntawm cov cystine dawb los ntawm cystinotic fibroblasts. Cov tshuaj uas muaj cysteamine tau siv los kho nephropathic cystinosis thiab txo qis glomerular deterioration hauv tib neeg.
Chemical Properties	Dawb Khoom
Siv	Cysteamine hydrochloride yog siv los ua antioxidant thiab hauv kev kho hluav taws xob.
Siv	Cysteamine hydrochloride tau siv nyob rau hauvhauv-situtiam ntawm chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) rau kev nkag siab ntawm Cd²⁺thiab S^2-.
Siv	Ib qho inhibitor ntawm DMBA-induced mammary qog2-Mercaptoethylamine hydrochloride ua tus thawj coj hauv taurine biosynthesis thiab cov khoom ntawm coenzyme A. Nws koom nrog hauv kev npaj cov tshuaj nquag xws li ranitidine thiab nizatidine. Nws ua raws li tshuaj tua kab mob rau acetaminophen lom. Tsis tas li ntawd, nws yog siv nyob rau hauv qhov ncauj kev kho mob ntawm nephropathic cystinosis, hluav taws xob mob thiab mob ntawm cysteine excretion. Ntxiv rau qhov no, nws ua haujlwm ua antioxidant thiab inhibitor ntawm 7, 12-Dimethylbenz[a]anthracene (DMBA)-induced qog.
Kev piav qhia dav dav	Cysteamine yog ib qho aminothiol uas tuaj yeem txo qhov tseem ceeb oxidized disulfide molecules xws li cystine kom tawm los cysteine.
Hazard	Toxic los ntawm inhalation thiab noj.
Biochem/physiol Actions	Cysteamine yog ib qho aminothiol uas tuaj yeem txo qhov tseem ceeb oxidized disulfide molecules xws li cystine kom tawm los cysteine. Cysteamine yog siv nyob rau hauv ib tug ntau yam ntawm daim ntaub ntawv los ntawm kev cai ntawm noob qhia, rau depletion ntawm somatostatin, rau txheej ntawm nanoparticles.
Synthesis	Tshwj xeeb rau synthesizing cysteamine hydrochloride nyob rau hauv alkali ib puag ncig, uas yog yus muaj los ntawm ethanolamine tov thiab sulfate tov yog siv raws li raw khoom; 2- amino ethyl sulfate yog thawj zaug ua ke ua ntej ua rau hauv lub nplhaib hauv cov tshuaj alkaline los ntawm 2-amino ethyl sulfate thiab carbon disulfide, yog li tau txais Alpha -mercaptothiazoline; alkaline hydrolysis yog tsim los ntawm Alpha-mercaptothiazoline los tsim cysteamine hydrochloride.
Txoj Kev Purification	Purify ntsev los ntawm recrystallisation los ntawm EtOH. Nws yog dawb do soluble hauv H2O thiab yuav tsum tau muab cia rau hauv qhov chaw qhuav. [Mills & Bogert J Am Chem Soc 62 1177 1940.] Cov duab muaj m 125-126o; saib yav dhau los nkag rau hauv paus dawb. [Beilstein 4 IV 1570.]

Cysteamine hydrochloride Kev npaj cov khoom thiab cov ntaub ntawv raw

Cov khoom nyoos	Hydrochloric acid-->Sulfuric acid-->Carbon disulfide-->Monoethanolamine
Cov khoom npaj	1,3-THIAZOLIDIN-2-ONE-->2-AMINOETHYLMETHYLSULFONE HYDROCHLORIDE-->THIAZOLIDINE-->Cystamine dihydrochloride-->N-(2-MERCAPTOETHYL)ACETAMIDE-->Thiazolidine, hydrochloride (1:1)-->2-METHYLTHIAZOLIDINE-->3-Thiomorpholineacetic acid, methyl ester-->2-(butylthio)ethanamine-->2-(3-Methylphenyl)thiazolidine, 97%-->S-BENZOYLCYSTEAMINE HYDROCHLORIDE-->2-(propylthio)ethanamine(SALTDATA: HCl)

Cim npe nrov: Tuam Tshoj cysteamine hydrochloride manufacturers, lwm tus neeg, Hoobkas

Tug: 4-Methylmorpholine

Tom ntej: Sodium Trifluoromethanesulfinate

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