Khoom Taw qhia
| 6-methoxy-1-tetralon Cov ntaub ntawv yooj yim |
| Khoom npe: | 6-methoxy-1-tetralon |
| Synonyms: | 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-IB;6-METHOXY-1,2,3,{10}} TETRAHYDRO-1-NAPHTHALENONE;6-METHOXY-1,2,3,4-TETRAHYDRO-1-NAPHTHONE;6-METHOXY-3,{ {20}}DIHYDRO-2H-NAPHTHALEN-1-IB;6-METHOX-1-TETRALONE;6-METHOXY TETRALONE;6-METHOXY-ALPHA- TETRALONE; TIMTEC-BB SBB007549 |
| CAS: | 1078-19-9 |
| MF: | C11H12O2 |
| MW: | 176.21 |
| EINECS: | 214-078-0 |
| Khoom Categories: | Ketone; C11 txog C12; Carbonyl Compounds; Carbonyl Compounds; Ketones |
| Mol File: | 1078-19-9.mol |
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| 6-methoxy-1-tetralon Chemical Properties |
| Melting point | 77-79 degree (lit.) |
| Boiling point | 171 degree / 11 mmHg (lit.) |
| ceev | 1.0558 (zeeg) |
| Refractive Index | 1.5250 (kwv yees) |
| Fp | 171 degree / 11 hli |
| cia temp. | Muab kaw rau hauv qhuav, Chav Kub |
| daim ntawv | Fine Crystalline hmoov |
| xim | Yellow rau lub teeb xim av |
| PH | 5.96 ntawm 23 degree thiab 10g / L |
| Merck | 14,6000 |
| BRN | 972739 |
| InChIKey | MNALUTYMBUBKNX-UHFFFAOYSA-N |
| CAS DataBase Reference | 1078-19-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-(1078-19-9) |
| EPA Tshuaj Registry System | 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy- (1078-19-9) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xn, xis |
| Risk Statements | 22-36/37/38-20/21/22 |
| Cov lus hais txog kev nyab xeeb | 24/25-36-26 |
| WGK Germany | 3 |
| Kev Ceeb Toom | Irritant |
| TSCA | Yog lawm |
| HS Code | 29145000 |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| 6-Methoxytetralon | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| 6-methoxy-1-Tetralone Siv Thiab Synthesis |
| Chemical Properties | daj mus rau lub teeb xim av zoo crystalline hmoov |
| Siv | 6-Methoxy-1-tetralone yog ib qho reagent muaj txiaj ntsig hauv kev sib xyaw ntawm (2-(furanyl)vinyl)-1-tetralone chalcones uas muaj cov tshuaj tiv thaiv kab mob thiab inducers ntawm apoptosis. |
| Txhais | ChEBI: 6-Methoxy-1-tetralon yog ib tug tswv cuab ntawm tetralins. |
| Kev npaj | (1) Reacting anisole nrog ib tug acylating tus neeg sawv cev nyob rau hauv Lewis acid thiab ib tug hnyav ntawm qhov kub thiab txias ntawm -10-40 degree los tsim ib tug intermediate 1, nyob rau hauv lub molar ratio ntawm Lewis acid rau cov acylating tus neeg saib xyuas rau lub anisole yog {{3 } }: 1-10: 1, Lewis acid yog xaiv los ntawm ib los yog ntau tshaj ntawm concentrated sulfuric acid, phosphoric acid, polyphosphoric acid, zinc chloride, aluminium trichloride, superacid thiab heteropoly acid; (2) qhov nruab nrab 1 tsis tas yuav tsum tau sib cais, qhov kub thiab txias tau nce mus rau 70-120 degree , thiab qhov nruab nrab 1 txuas ntxiv mus ua kom muaj 6-methoxy-1-tetralon; (3) txias cov tshuaj tiv thaiv cov khoom, ntxiv dej kom tsis txhob muaj cov tshuaj tiv thaiv, tshem tawm, purifying thiab desolventizing kom tau ib tug crude khoom ntawm cov 6-methoxy-1-tetralon, thiab refining cov khoom crude los ntawm ib tug hnyav kom tau high-purity khoom. |
| Synthesis Reference (cov) | Phau ntawv Journal of the American Chemical Society, 64, p. 94 Ib., 1942DOI:10.1021/ja01253a025 Tetrahedron Letters, 9, p. 2917 Ib., 1968DOI: 10.1016/S0040-4039(00)89611-2 |
| Synthesis | Lub synthesis ntawm {{0}}methoxy-1-tetralone yog raws li nram no: Eaton's reagent (1.00 mL, 5.31 mmol) tau maj mam ntxiv rau cov tshuaj tov ntawm methyl {{6 }}(3-methoxyphenyl)butanoate (4; 0.37g, 1.78 mmol) hauv DCE (1 mL). Lub resulting sib tov yog stirred ntawm 75 degree rau 2h nyob rau hauv N2huab cua. Tom qab ntawd, cov tshuaj tiv thaiv sib xyaw tau tso cai kom ncav cuag qhov kub thiab txias, thiab muab tso rau hauv dej khov thiab muab rho tawm nrog EtOAc (3 × 15 mL). Cov organic sib xyaw ua ke tau muab ntxuav ua ntu zus nrog brine (2 × 15 mL) thiab H2O (2 × 20 mL), lim dhau Na2YOG4thiab concentrated nyob rau hauv txo siab. Cov roj uas muaj xim av tau muab faib ua ke los ntawm kab chromatography (silica gel, EtOAc-hexanes, 1:9) kom tau txais 6-methoxy-1-tetralone li ayellowish roj; yield: 0.28 g (91%). |
| 6-methoxy-1-Tetralone Preparation Products Thiab Raw Materials |
| Cov khoom siv raw | FUMING SULFURIC ACID-->Detergent-->6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE |
| Cov khoom npaj | 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal-->3-Methoxy-18-methylestra-2,5(10)dien-17-one 17-ethylene ketal-->17-Ethinyl-3,17-dihydroxy-18-methylestra-2,5(10)-diene3-methylether-->3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17-ethylene ketal-->6-CYANO-1-TETRALONE-->6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one-->4-Methoxyphthalic acid-->2-Methoxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one-->2-[2-(6-methoxytetralin-1-ylidene)-ethyl]-2-methylcyclopentane-1,3-dione -->1-CHLORO-6-METHOXY-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE-->7-METHOXY-4, 5-DIHYDRO-NAPHTHO[1,2-D]THIAZOL-2-YLAMINE |
Cim npe nrov: 6-methoxy-1-tetralon, Tuam Tshoj 6-methoxy-1-tetralon manufacturers, lwm tus neeg, Hoobkas
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