Khoom Taw qhia
| 4'-Hydroxyacetophenone Cov ntaub ntawv yooj yim |
| Khoom npe: | 4'-Hydroxyacetophenone |
| Synonyms: | 1-(4-hydroxyphenyl)-ethanon; 4'-hydroxy-acetophenon; 4-Hydroksyacetofenol; Acetophenone, p-hydroxy-; Ethanone, 1-(4-} hydroxyphenyl)-;Hydroxyacetophenone, para;HYDROXYACETOPHENONE-4;HYDROXYBENZOPENONE-4 |
| CAS: | 99-93-4 |
| MF: | C8H8O2 |
| MW: | 136.15 |
| EINECS: | 202-802-8 |
| Khoom Categories: | Pyridines; Pharmaceutical intermediates rau Choleretic thiab Salbutamol; Aromatic Acetophenones & Derivatives (hloov); Aromatics; Lwm yam Reagents; Eczema, tshuaj thiab lwm yam organic synthesis intermediates; Acetophenone Series; FINE Chemical & INTERMEDIATES; CEEB TOOM 8 Photoinitiators ;Polymerization Initiators; Carbonyl Compounds;bc0001;99-93-4;1 |
| Mol File: | 99-93-4.mol |
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| 4'-Hydroxyacetophenone Cov Khoom Siv Tshuaj |
| Melting point | 132-135 degree (lit.) |
| Boiling point | 147-148 degree 3 mm Hg (lit.) |
| ceev | 1.109 |
| vapor siab | 0.002Pa ntawm 20 degree |
| Refractive Index | 1.5577 (kwv yees) |
| FEMA | 4330|4-HYDROXYACETOPHENONE |
| Fp | 166 degree |
| cia temp. | Khaws hauv qab +30 degree . |
| solubility | methanol: 0.1 g/mL, ntshiab |
| daim ntawv | Crystalline hmoov |
| pka ua | 8.05 (ntawm 25 degree) |
| xim | Yuav luag dawb rau beige |
| Specific Gravity | 1.109 |
| tsw | ntawm 10.00 % hauv dipropylene glycol. me ntsis qab zib hawthorn balsam mimosa |
| Hom tshuaj tsw qab | paj ntoo |
| Dej Solubility | 10 g/L (22 ºC) |
| JECFA Number | 2040 |
| BRN | 774355 |
| InChIKey | TXFPEBPIARQUIG-UHFFFAOYSA-N |
| LogP | 1.35 ntawm 25 degree |
| CAS DataBase Reference | 99-93-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetophenone, 4'-hydroxy-(99-93-4) |
| EPA Tshuaj Registry System | 4-Hydroxyacetophenone (99-93-4) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xn, xis |
| Risk Statements | 36/37/38-22 |
| Cov lus hais txog kev nyab xeeb | 26-36/37-37/39-24/25-22-36 |
| WGK Germany | 3 |
| RTECS | PC4959775 |
| Ceeb toom | Irritant |
| TSCA | Yog lawm |
| HS Code | 29145000 |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| 1-(4-Hydroxyphenyl) ethanone | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| 4'-Hydroxyacetophenone Siv Thiab Synthesis |
| Chemical Properties | yuav luag dawb rau beige crystalline hmoov |
| Chemical Properties | Dawb rau beige hmoov; qab zib, hawthorn, balsam, mimosa aroma |
| Qhov tshwm sim | Tshaj tawm pom muaj nyob rau hauv cloudberry, kas fes, cranberry, mango, sherry, thiab wort. |
| Siv | 4?-Hydroxyacetophenone tau siv los ua ketone tivthaiv hauv kev npaj ntawm 1-aryl-3-phenethylamine-1-propanone hydrochlorides, muaj peev xwm cytotoxic agents, ntawm Mannich cov tshuaj tiv thaiv. |
| Siv | 4'-Hydroxyacetophenone tau siv los ua ketone tivthaiv hauv kev npaj ntawm 1-aryl-3-phenethylamine-1-propanone hydrochlorides, muaj peev xwm cytotoxic agents, ntawm Mannich cov tshuaj tiv thaiv. |
| Siv | p-Hydroxyacetophenone yog dav siv hauv tshuaj, tshuaj pleev ib ce thiab kev lag luam. Nws yog cov nroj tsuag ntuj extract, uas ib txwm muaj nyob rau hauv stems thiab nplooj ntawm Compositae nroj tsuag, Artemisia annua, cov hauv paus hniav ntawm cov nroj tsuag xws li Artemisia annua, Rhododendron, thiab Panax ginseng. Nws muaj cov txiaj ntsig zoo ntawm qhov muag daj tshwm sim los ntawm cov kab mob xws li kab mob siab, thiab tseem muaj cov txiaj ntsig zoo ntawm qhov muag daj tshwm sim los ntawm ntau yam laj thawj. Vim nws cov kev ua haujlwm tsis muaj zog molecular, kub tsis kam, melting point ntawm 95-97 degree thiab boiling point ntawm 296 degree, nws yog dav siv nyob rau hauv ntau yam kua tshuaj thiab muaj peev xwm ncua lub txee lub neej ntawm lwm yam khoom xyaw nyob rau hauv kub kub. Nws tsis muaj kev phom sij rau tib neeg cov tawv nqaij thiab yog qhov zoo tshaj plaws kub-kub auxiliary active stabilizer hauv kev lag luam kws tshuaj. |
| Daim ntawv thov | 4'-Hydroxyacetophenone tau raug pom zoo siv rau hauv cov tshuaj tsw qab los ua ib qho kev hloov kho rau ntau cov pa derivatives ntawm Acetophenonc, thiab lwm yam. feem ntau nyob rau hauv hnyav-floral lossis woodyfloral fragrances qhov twg lub hwj chim thiab tus nqi qis arc thov. |
| Txoj kev tsim khoom | 4'-Hydroxyacetophenone tuaj yeem tsim tawm 1) los ntawm Phenylacetate los ntawm cua sov nrog Aluminium chloride. 2) los ntawm Phenol, Acetylchlonde thiab Aluminium chloride los ntawm Friedel-Craft' cov tshuaj tiv thaiv. |
| Kev npaj | Kev npaj los ntawm Fries rearrangement ntawm phenyl acetate nrog Lewis acids aluminium chloride nyob rau hauv nitrobenzene ntawm 20-25 degree los yog ntawm 50-60 degree nyob rau hauv chlorobenzene ntawm 45 degree thiab 65 degree, kaw lub raj thiab raug rau siab zog microwave irradiation rau 2 min xwb (36%) nyob rau hauv nitroethane ntawm 60 degree (44%) nyob rau hauv carbon disulfide ntawm 45 degree (40%) hauv roj av ether ntawm 50 degree (20%) Tab sis ntawm 130 degree thiab 175 degree (40-60%) aluminium chloride-sodium chloride sib tov ntawm 240-250 degree (10%) boron trifluoride ntawm 90 degree (56%) scandium tris (trifluoromethanesulfonate), hauv nitromethane, ntawm 50 degree (39%) titanium tetrachloride ntawm 90-100 degree (34%) ferric chloride ntawm 65 degree (25%) zinc chloride ntawm 125 degree (8%) hydrofluoric acid, ntawm 20 degree thiab 100 degree (94%) polyphosphoric acid, ntawm 20 degree thiab 100 degree (69%) (50–53%) (44%) Nafion-XR 500, sulfonic acid hom ntawm 100 degree ZSM{0}}, hauv sulfolane, ntawm 180 degree (28%) H-ZSM-5 ntawm 400 degree lossis ntawm 210 degree (6%) H-Nu-2 ntawm 170 degree (15%) HY (Si/Al=3) los yog fluorided alumina (Al2O3-F; 3% wt. F), ntawm 400 degree . |
| Txhais | ChEBI: Ib qho monohydroxyacetophenone nqa hydroxy hloov ntawm txoj hauj lwm 4'. |
| Aroma pib qhov tseem ceeb | Floral hom, nruab nrab lub zog tsw; pom zoo kom hnov tsw hauv 10.00% tov lossis tsawg dua. |
| Synthesis Reference (cov) | Tetrahedron Letters, 32, p. 5829, 1991 ibDOI: 10.1016/S0040-4039(00)93567-6 |
| Kev piav qhia dav dav | Pharmaceutical Secondary qauv rau daim ntawv thov nyob rau hauv kev tswj kom zoo muab pharma laboratories thiab manufacturers nrog ib tug yooj yim thiab nqi-zoo lwm txoj rau kev npaj cov qauv kev ua hauj lwm hauv tsev. |
| Flammability thiab Explosibility | Tsis yog nplaim taws |
| Txoj Kev Purification | Crystallize nws los ntawm diethyl ether, aqueous EtOH los yog * benzene / tsiaj ether. [Beilstein 8 H 87, 8 IV 339.] |
| 4'-Hydroxyacetophenone Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw |
| Cov khoom nyoos | Aluminum chloride-->2'-Hydroxyacetophenone-->4-Aminoacetophenone-->PHENYL ACETATE |
| Cov khoom npaj | Acetaminophen-->4-Vinylphenol-->4-Acetoxystyrene-->4-Benzyloxy-3-nitroacetophenone-->4-QUINOXALIN-2-YLPHENOL-->HPG-->4-Acetyloxy-3-acetyloxymethyl-(N-benzyl-N-tertbutylamino)acetophenone hydrochloride-->4-Hydroxyphenethyl alcohol-->1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE-->1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone-->1,1,1-Tris(4-hydroxyphenyl)ethane-->Atenolol-->Micafungin Side Chain Methyl Ester-->3',5'-DICHLORO-4'-HYDROXYACETOPHENONE-->4-HYDROXYBENZOYLACETIC ACID METHYL ESTER-->4'-PIPERIDINOACETOPHENONE-->2-(4-HYDROXYPHENYL) PROPIONIC ACID |
Cim npe nrov: 4'-hydroxyacetophenone, Tuam Tshoj 4'-hydroxyacetophenone manufacturers, lwm tus neeg, Hoobkas
Tug: 6-methoxy-1-tetralon
Tom ntej: 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE
Koj Tseem Yuav Zoo Li
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