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4-Cyanopyridine

4-Cyanopyridine

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4-Cyanopyridine Cov ntaub ntawv yooj yim
Khoom npe: 4-Cyanopyridine
Synonyms: ISONICOTINIC ACID NITRILE;ISONICOTINONITRILE;AKOS BBS-00004486;4-PYRIDINECARBONITRILE;4-CYANOPYRIDINE;4-Pyridinecarbonitrile 98%;{{4-PyridineCARBONITRILE;4-CYANOPYRIDINE;4-Pyridinecarbonitrile 98%;{{-00004486 Impurity B(6}Isonia)); }cyanopyridine (4-CP)
CAS: 100-48-1
MF: C6H4N2
MW: 104.11
EINECS: 202-856-2
Khoom Categories: Heterocycle-Pyridine series; cyanide; Pyridines derivates; bc0001
Mol File: 100-48-1.mol
4-Cyanopyridine Structure
 
4-Cyanopyridine Chemical Properties
Melting point 76-79 degree (lit.)
Boiling point 196 degree
ceev 1.1145 (zeeg)
vapor siab 41.9Pa ntawm 25 degree
Refractive Index 1.5242 (kwv yees)
Fp 88 degree
cia temp. Muab kaw rau hauv qhuav, Chav Kub
solubility 40g/l
pka ua pK1: 1.90 (+1) (25 degree)
daim ntawv Crystals los yog hmoov
xim Dawb mus rau dawb
Dej Solubility 3.2 g / 100 ml (16.4 ºC)
BRN 107712
Kev txwv tsis pub dhau NIOSH: IDLH 25 mg/m3
Kev ruaj ntseg: ruaj khov. Tsis sib haum nrog cov hauv paus muaj zog, muaj zog oxidizing cov neeg ua haujlwm, muaj zog acids.
InChIKey GPHQHTOMRSGBNZ-UHFFFAOYSA-N
LogP 0.46 ntawm 25 degree
CAS DataBase Reference 100-48-1(CAS DataBase Reference)
NIST Chemistry Reference 4-Pyridinecarbonitrile (100-48-1)
EPA Tshuaj Registry System 4-Pyridinecarbonitrile (100-48-1)
 
Cov ntaub ntawv kev nyab xeeb
Hazard Codes Xn
Risk Statements 20/21/22
Cov lus hais txog kev nyab xeeb 36/37-24/25
RIDADR 3276
WGK Germany 3
TSCA Yog lawm
PackingGroup III
HS Code 29333999
 
MSDS Cov Ntaub Ntawv
Tus kws kho mob Lus
4-Cyanopyridine Lus Askiv
SigmaAldrich Lus Askiv
ACROS Lus Askiv
ALFA Lus Askiv
 
4-Cyanopyridine Siv Thiab Synthesis
Chemical Properties beige khoom
Chemical Properties Cov cyanopyridines yog raws li nram no: 2-cyano-: Ib tug dawb mus rau tan kua los yog khoom. Almond tsw. Boiling point =2213 degree ; khov / melting point =27 degree ; flash point =89 degree . 3-cyano-: cov kua tsis muaj xim lossis grey crystal-line khoom.
Siv 4-Cyanopyridine yog siv los ua ib qho nruab nrab hauv cov organic synthesis thiab tshuaj tshuaj xws li isonicotinylhydrazide, uas yog siv rau kev kho mob tuberculosis. Nws yog siv los ua tus thawj coj rau kev npaj ntawm isonicotinic acid thiab 4-diemthylaminopyridine (DMAP). Nws koom nrog hauv kev sib txuas ntawm 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine los ntawm kev ua haujlwm nrog acetonitrile.
Synthesis 4-Cyanopyridine yog synthesized los ntawm cov tshuaj tiv thaiv ntawm 4-methylpyridine nrog ammonia thiab cua nyob rau hauv lub xub ntiag ntawm ib tug catalyst. Cov txheej txheem synthesis tshwj xeeb yog raws li hauv qab no:
{{{0}}Methylpyridine thiab ammonia vaporisation preheating mus rau 180-330 degree , ces mus rau hauv lub tank sib tov thiab cua sib tov sib xyaw, mus rau hauv lub txaj ruaj ruaj reactor los ntawm sab saum toj ntawm lub txaj ruaj khov reactor tom qab kev faib khoom ntawm lub catalyst-filled reactor, tswj cov tshuaj tiv thaiv kub nyob rau hauv qhov ntau ntawm 330-450 degree C, cov tshuaj tiv thaiv lub taub hau siab yog tswj nyob rau hauv qhov ntau ntawm 0.020-0.070 KPa, cov tshuaj tiv thaiv kub yog tswj los ntawm molten ntsev, cov tshuaj tiv thaiv roj tom qab qhov kawg ntawm cov tshuaj tiv thaiv Tom qab cov tshuaj tiv thaiv, cov tshuaj tiv thaiv roj tau condensed rau sub-zero fractionation kom tau cov khoom crude ntawm 4-cyanopyridine, thiab cov khoom crude yog distilled kom tau cov cov khoom tiav ntawm 4-cyanopyridine. Tus nqi hloov pauv ntawm 4-methylpyridine yog siab dua 99%, thiab cov txiaj ntsig ntawm 4-cyanopyridine yog siab dua 98%.
4-Cyanopyridine synthesis
Ntxim yuav nphav raug Kev txwv hauv Cua NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, tsis pub tshaj nyob rau hauv ib qho 15- feeb ua hauj lwm lub sij hawm.
Kev xa khoom UN3276 Nitriles, kua, tshuaj lom, nos, Hazard Class: 6.1; Cov ntawv lo: 6.1- Cov ntaub ntawv muaj kuab lom, Cov Khoom Siv Lub Npe Yuav Tsum Tau, Muaj peev xwm nqus tau qhov phom sij (Tshwj xeeb 5).
Kev tsis sib haum xeeb Cov tshuaj oxidizing, xws li perchlorates, peroxides, thiab permanganates. Nitriles tej zaum yuav polymerize nyob rau hauv lub xub ntiag ntawm hlau thiab ib co hlau tebchaw. Lawv yog incompatible nrog acids; sib tov nitriles nrog oxidizing acids muaj zog tuaj yeem ua rau muaj kev kub ntxhov heev. Nitriles feem ntau tsis sib haum nrog lwm cov tshuaj oxidizing xws li peroxides thiab epoxides. Kev sib xyaw ntawm cov hauv paus thiab nitriles tuaj yeem tsim hydrogen cyanide. Nitriles yog hydrolyzed nyob rau hauv ob qho tib si aqueous acid thiab hauv paus muab carboxylic acids (los yog ntsev ntawm carboxylic acids). Cov tshuaj tiv thaiv no ua kom sov. Peroxides hloov nitriles rau amides. Nitriles tuaj yeem ua rau muaj zog nrog cov tshuaj txo qis. Acetonitrile thiab propionitrile yog soluble nyob rau hauv dej, tab sis nitriles siab tshaj propionitrile muaj tsawg aqueous solubility. Lawv kuj yog insoluble nyob rau hauv aqueous acids.
 
4-Cyanopyridine Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw
Cov khoom nyoos 4-Pyridinealdoxime-->Isonicotinamide
Cov khoom npaj 4-Pyridinemethaneamine-->2-tert-Butylpyridine-4-carboxylic acid ,97%-->2-TERT-BUTYLPYRIDINE-4-CARBONITRILE-->4-[(TERT-BUTOXYCARBONYLAMINO)METHYL]-2-CYANOPYRIDINE-->4-AMINOMETHYL-PYRIDINE-2-CARBOXYLIC ACID-->4-(BOC-AMINOMETHYL)PYRIDINE-2-CARBOXYLIC ACID-->2-Picolylamine-->3-Chloro-4-cyanopyridine-->4-PYRIDINECARBOXAMIDINE-->4-CYANOPYRIDIN-3-YLBORONIC ACID-->4-AMIDINOPYRIDINIUM CHLORIDE-->4-(4-CHLOROBENZOYL)PYRIDINE-->PYRIDINE-2,4-DICARBONITRILE-->4-TERT-BUTYLPYRIDINE-->4-(BOC-AMINOMETHYL)PYRIDINE-->N'-HYDROXYPYRIDINE-4-CARBOXIMIDAMIDE-->4-Pyridylcarbinol-->Ethyl isonicotinate-->2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE

Cim npe nrov: 4-cyanopyridine, Tuam Tshoj 4-cyanopyridine manufacturers, lwm tus neeg, Hoobkas

Tom ntej: 2-Cyanopyridine

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