Khoom Taw qhia
| 1,4-Butanediol Cov ntaub ntawv yooj yim |
| Khoom npe: | 1, 4-Butanediol |
| Synonyms: | 1,4-BUTYLENE GLYCOL;1,4-BUTANEDIOL;1,4-DIHYDROXYBUTANE;AKOS BBS-00004303;BDO;BUTANEDIOL,1,4-;TETRAMETHYLENE GLYCOL VERSALINK CURATIVE 1,4 BDO |
| CAS: | 110-63-4 |
| MF: | C4H10O2 |
| MW: | 90.12 |
| EINECS: | 203-786-5 |
| Khoom Categories: | Tshuaj; 1,4 BDO; Tsev Blocks; Cov kuab tshuaj; Cov kuab tshuaj; cov kuab tshuaj thiab cov tshuaj nruab nrab; Cov Tshuaj Synthesis; Organic Building Blocks; Oxygen Compounds; Polyols; 110-63-4; BDO |
| Mol File: | 110-63-4.mol |
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| 1,4-Butanediol Cov Khoom Siv Tshuaj |
| Melting point | 16 degree (lit.) |
| Boiling point | 230 degree (lit.) |
| ceev | 1.017 g / mL ntawm 25 degree (lit.) |
| vapor ceev | 3.1 (vs huab cua) |
| vapor siab | <0.1 hPa (20 °C) |
| Refractive Index | n20 / D 1.445 (lit.) |
| Fp | 135 degree |
| cia temp. | Khaws hauv qab +30 degree . |
| pka ua | 14.73 ± 0.10 (Tswj) |
| daim ntawv | Ua kua |
| xim | Ntshiab xim tsis muaj xim |
| PH | 7-8 (500g/l, H2O, 20 degree) |
| tsw | Tsis hnov tsw |
| tawg txwv | 1.95-18.3%(V) |
| Dej Solubility | Miscible |
| rhiab heev | Hygroscopic |
| BRN | 1633445 |
| Dielectric tsis tu ncua | 3 0.0 (30 degree) |
| Kev ruaj ntseg: | ruaj khov. Hluav taws kub. Incompatible nrog muaj zog oxidizing neeg sawv cev, ntxhia acids, acid chlorides, acid anhydrides. |
| InChIKey | WERYXYBDKMZEQL-UHFFFAOYSA-N |
| LogP | -0.88 ntawm 25 degree |
| CAS DataBase Reference | 110-63-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1, 4-Butanediol (110-63-4) |
| EPA Tshuaj Registry System | 1, 4-Butanediol (110-63-4) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xn |
| Risk Statements | 22-67 |
| Cov lus hais txog kev nyab xeeb | 36-23-24/25 |
| WGK Germany | 1 |
| RTECS | EK0525000 |
| Autoignition Kub | 698 degree F |
| TSCA | Yog lawm |
| HS Code | 29053980 |
| Cov Ntaub Ntawv Muaj Xwm Ceev | 110-63-4(Cov ntaub ntawv muaj phom sij) |
| Toxicity | LD50 qhov ncauj hauv luav: 1525 mg/kg LD50 dermal luav > 2000 mg/kg |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| 1, 4-Dihydroxybutane | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| 1,4-Butanediol Siv Thiab Synthesis |
| Chemical Properties | 1,4-butanediol (1,4-BD) yog ib qho tsis muaj xim, kua nplaum uas tau los ntawm butane los ntawm kev tso cov cawv pawg ntawm txhua qhov kawg ntawm nws cov saw molecular thiab yog ib qho ntawm plaub lub isomers ruaj khov ntawm butanediol.the hydroxyl muaj nuj nqi ntawm txhua pab pawg kawg ntawm Butanediol reacts nrog sib txawv mono- thiab bifunctional reagents: piv txwv li nrog dicarboxylic acids rau polyesters, nrog diisocyanates rau polyurethanes, los yog nrog phosgene rau polycarbonates. 1. BDO thiab nws cov derivatives yog dav siv los tsim cov yas, cov kuab tshuaj, cov tshuaj hluav taws xob thiab cov elastic fibers. Tsis tas li ntawd, BDO tseem yog ib lub tsev thaiv rau kev sib txuas ntawm polyesterpolyols thiab polyetherpolyols. BASF yog tus tsim khoom tseem ceeb tshaj plaws ntawm 1,4-Butanediol thiab nws cov derivatives thoob ntiaj teb. |
| Siv |
Butanediol thiab nws cov derivatives yog siv dav hauv kev siv tshuaj lom neeg kev lag luam; ntawm lwm tus hauv kev tsim cov khoom siv yas, polyurethanes, cov kuab tshuaj, cov tshuaj hluav taws xob thiab cov elastic fibers. 1,4-Butanediol yog siv rau hauv kev sib txuas ntawm epothilones, chav kawm tshiab ntawm cov tshuaj mob qog noj ntshav. Kuj tseem siv nyob rau hauv stereoselective synthesis ntawm (-)-Brevisamide. 1,4-Butanediol siv ntau tshaj plaws yog nyob rau hauv tetrahydrofuran (THF) ntau lawm, siv los ua polytetramethylene ether glycol, uas feem ntau mus rau hauv spandex fibers, urethane elastomers, thiab copolyester ethers. Nws yog feem ntau siv los ua cov kuab tshuaj hauv kev lag luam tshuaj los tsim gamma-butyrolactone thiab elastic fibers zoo li spandex. Nws yog siv los ua tus neeg sawv cev sib txuas rau cov thermoplastic urethanes, polyester plasticizers, xim thiab coatings. Nws ua rau lub cev qhuav dej nyob rau hauv lub xub ntiag ntawm phosphoric acid yielded teterahydrofuran, uas yog ib qho tseem ceeb hnyav siv rau ntau yam kev siv. Nws ua haujlwm nruab nrab thiab siv los tsim cov polytetramethylene ether glycol (PTMEG), polybutylene terephthalate (PBT) thiab polyurethane (PU). Nws pom daim ntawv thov raws li kev siv tshuaj ntxuav thiab cov kua nplaum tshem tawm. 1; cov tshuaj ua liaj ua teb thiab tsiaj txhu thiab hauv cov txheej txheem (hauv cov xim, cov kua roj vanish thiab cov yeeb yaj kiab). |
| Siv | butylene glycol yog ib qho hnyav nrog cov tshuaj tua kab mob zoo. Nws txhim kho kev ua haujlwm ntawm parabens. Butylene glycol kuj ua hauj lwm raws li ib tug humectant thiab viscosity xws li, thiab daim npog qhov ncauj tsw. |
| Siv | 1, 4-Butanediol yog siv los tsim cov polybutyleneterephthalate, cov thermoplastic polyester; thiab ua tetrahydrofuran, butyrolactones, thiab polymeric plasticizers. |
| Txhais | ChEBI: Butane-1,4-diol yog butanediol uas yog butane uas ib hydrogen ntawm txhua pawg methyl hloov los ntawm ib pawg hydroxy. Ib qho xim tsis muaj xim, dej-miscible, viscous kua ntawm chav tsev kub (mp 16 degree) nrog lub siab kub kub (230 degree), nws yog tsuas yog siv rau kev tsim cov tshuaj organic, tshwj xeeb tshaj yog cov kuab tshuaj oxolane (tseem hu ua tetrahydrofuran lossis THF. ). Nws muaj lub luag haujlwm ua neurotoxin, protic hnyav thiab prodrug. Nws yog ib qho butanediol thiab glycol. |
| Txoj kev tsim khoom | Methods manufacturing: Qhov kev nthuav dav tshaj plaws 1,4-BD ntau lawm txoj kev thoob ntiaj teb yog BASF's Reppe txheej txheem, uas reacts acetylene thiab formaldehyde. Acetylene reacts nrog ob qhov sib npaug ntawm formaldehyde rau daim ntawv 1, 4-butynediol, tseem hu ua but-2-yne- 1, 4-diol. Hydrogenation ntawm 1,4-butynediol muab 1,{10}}butanediol. 1,4-BD kuj tseem ua los ntawm kev lag luam loj los ntawm kev txuas ntxiv hydrogenation ntawm 2-butyne- 1,4-diol dhau hloov cov nickel catalysts. Cov txheej txheem ntws ib-theem yog ua tiav ntawm 80 - 160 deg C thiab 300 bar. Mitsubishi siv cov txheej txheem peb-kauj ruam: (1) cov tshuaj tiv thaiv catalytic ntawm butadiene thiab acetic acid yields 1, 4-diacetoxy-2-butene; (2) tom qab hydrogenation muab 1,4-diacetoxybutane; thiab (3) hydrolysis ua rau 1, 4-butanediol. |
| Synthesis Reference (cov) | Phau ntawv Journal of Organic Chemistry, 36, p. Xyoo 2018, 1971DOI:10.1021/j00813a043 Tetrahedron Letters, 33, p. 6371, 1992 ibDOI: 10.1016/S0040-4039(00)60976-0 |
| Kev piav qhia dav dav | Tsis muaj ntxhiab tsw muaj xim tsis muaj kua lossis khoom (nyob ntawm qhov kub thiab txias). |
| Cua & Dej Reactions | Cov nplaim taws heev. 1, 4-Butanediol yog hygroscopic. Dej soluble. |
| Reactivity Profile | 1,4-Butanediol yog cua sov thiab lub teeb rhiab heev. 1, 4-Butanediol reacts nrog acid chlorides, acid anhydrides thiab chloroformates; reacts nrog oxidizing agents thiab txo cov neeg ua haujlwm. 1,4-Butanediol tsis sib haum nrog isocyanates thiab acids; kuj tsis sib haum nrog peroxides, perchloric acid, sulfuric acid, hypochlorous acid, nitric acid, caustics, acetaldehyde, nitrogen peroxide thiab chlorine. |
| Hazard | Toxic los ntawm kev noj tshuaj. |
| Health Hazard | Cov mob toxicosis yog mob me. 1. Tus nqi ntawm qhov ncaujLD50 hauv nas dawb thiab guinea pigsis ~ 2 mL / kg. Cov tsos mob lom los ntawm kev noj haus yuav muaj xws li kev zoo siab, kev nyuaj siab ntawm lub hauv nruab nrab lub paj hlwb, xeev siab, thiab tsaug zog. |
| Health Hazard | Kev noj ntau npaum li cas yuav tsum ua kom muaj cov tsos mob. |
| Hluav Taws Xob | Nonflammable kua, flash point (qhib khob) 121 degree . |
| Kev ruaj ntseg Profile | Ib tug tib neeg tshuaj lom los ntawm ib tug unspecified txoj kev. Muaj tshuaj lom los ntawm kev noj zaub mov zoo thiab cov kab mob intraperitoneal. Tib neeg cov teebmeem: hloov sijhawm pw tsaug zog. Combustible thaum raug tshav kub los yog nplaim taws. Txhawm rau tua hluav taws, siv cawv ua npuas ncauj, pos huab, ua npuas ncauj, CO2, tshuaj qhuav qhuav. Incompatible nrog oxidizing cov ntaub ntawv. Thaum rhuab mus rau decomposition nws emits pa taws thiab fumes. |
| Solubility hauv dej | 1,4-Butanediol yog soluble hauv dej, cawv, esters, ketones, glycol ethers thiab glycol ether acetates (Butanediol, Butenediol, thiab Butynediol). |
| Txoj Kev Purification | Distil glycol thiab khaws cia rau Linde hom 4A molecular sieves, los yog crystallize nws ob zaug los ntawm anhydrous diethyl ether / acetone, thiab redistil nws. Nws tau recrystallised los ntawm yaj thiab muab ob npaug rau distilled nyob rau hauv vacuo nyob rau hauv lub xub ntiag ntawm Na2SO4. [Beilstein 1 IV 2515.] |
| 1,4-Butanediol Preparation Products Thiab Raw Materials |
| Cov khoom nyoos | Formaldehyde-->Nickel-->1,3-Butadiene-->Acetylene-->2,3-Butanedione-->2-Butyne-1,4-diol-->2-chloro-1,3-butadiene-->cis-1,4-Dichloro-2-butene-->3-hydroxy-2-methyl propionaldehyde-->DIMETHYL MALEATE-->2-HYDROXYTETRAHYDROFURAN |
| Cov khoom npaj | Tetrahydrofuran-->Gamma Butyrolactone-->Polyurethane-->Triethylene glycol dimethacrylate-->1,4-Dibromobutane-->Poly(butylene terephthalate)-->GD visible light curing composite resin-->PolyesterPolyol-->2,3-Dihydrofuran-->1,4-BUTANEDIOL DIACRYLATE-->4-Hydroxybutyl acrylate-->Polyvinylpyrrolidone-->Busulfan-->Pyrrolidine |
Cim npe nrov: 1,4-butanediol, Tuam Tshoj 1,4-butanediol manufacturers, lwm tus neeg, Hoobkas
Tug: 4-Methoxy-1-butanol
Tom ntej: 1-Dodecanol
Koj Tseem Yuav Zoo Li
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