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Ethylenediaminetetraacetic Acid Disodium ntsev

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Ethylenediaminetetraacetic acid disodium ntsev Cov lus qhia yooj yim

Kev piav qhia siv Cov Ntawv Qhia

Khoom npe:	Ethylenediaminetetraacetic acid disodium ntsev
Synonyms:	SEQUESTRENE NA2; SODIUM (DI) ETHYLENEDIAMINE TETRAACETATE DIHYDRATE; VERSENE NA, DIHYDRATE; VERSENE DISODIUM; WANKLYN'S EDTA; Ceftriaxone Impurity 21 (EDTA Disodium); disodium traacetenediaminte
CAS:	139-33-3
MF:	C10H14N2Na2O8
MW:	336.21
EINECS:	205-358-3
Khoom Categories:	Chelating agent; INORGANIC & ORGANIC CHEMICALS; EDTA; 139-33-3
Mol File:	139-33-3.mol

Ethylenediaminetetraacetic acid disodium ntsev Chemical Properties

Melting point	248 degree (lub kaum hli ntuj) (lit.)
Boiling point	>100 degree
ceev	1.01 g / ml ntawm 25 degree
vapor siab	0Pa ntawm 25 degree
cia temp.	2-8 degree
solubility	H₂O: ntshiab, tsis muaj xim
daim ntawv	daws
xim	Tsawg dua lossis sib npaug li 5 (0.5 M)(APHA)
tsw	ntawm 100.00?%. tsw tsw
Dej Solubility	Miscible nrog dej.
BRN	3822669
Kev ruaj ntseg:	Hygroscopic
LogP	-4.3 ntawm 25 degree
CAS DataBase Reference	139-33-3(CAS DataBase Reference)
EPA Tshuaj Registry System	Ethylenediaminetetraacetic acid disodium ntsev (139-33-3)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	Xn, C
Risk Statements	36/38-36/37/38-22-34-21/22
Cov lus hais txog kev nyab xeeb	26-36-37/39-45-36/37/39-36/37
WGK Germany	2
RTECS	AB 441000
TSCA	Yog lawm
HS Code	29224999
Cov Ntaub Ntawv Muaj Xwm Ceev	139-33-3(Cov ntaub ntawv muaj phom sij)
Toxicity	nas, LD50, intraperitoneal, 260mg / kg (260mg / kg), Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52 ,pab. 126 Ib., 1956.

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
(Ethylenedinitrilo) tetraacetic acid disodium ntsev	Lus Askiv
ACROS	Lus Askiv
SigmaAldrich	Lus Askiv
ALFA	Lus Askiv

Ethylenediaminetetraacetic acid disodium ntsev Siv Thiab Synthesis

Kev piav qhia	Ethylenediaminetetra-acetic acid (lub npe hu ua EDTA) yog siv rau hauv ntau daim ntawv thov kev lag luam uas ua rau nws muaj peev xwm los khi rau feem ntau ntawm cov hlau cations. EDTA yog tsim los ua ntau cov ntsev, xws li ethylenediaminetetra-acetic acid disodium ntsev (EDTAS). EDTA thiab nws cov ntsev yog siv los ua cov tshuaj chelates hauv cov tshuaj pleev ib ce. EDTAS yog ib qho kev khaws cia, sequestrant, thiab stabilizer hauv cov khoom noj. EDTA yog ntxiv rau ascorbic acid-disodium benzoate uas muaj cov dej qab zib kom txo qis kev tsim ntawm benzene. EDTA thiab nws cov ntsev yog siv los ua ib feem ntawm cov khoom noj-hu rau daim ntawv thiab cov ntawv ntawv. EDTAS tau tso cai nyob rau hauv pub thiab haus dej ntawm cov tsiaj thiab / los yog rau kev kho mob ntawm cov tsiaj ua zaub mov. Hauv kev lag luam textile, EDTA thiab nws cov ntsev tiv thaiv cov hlau ion impurities los ntawm kev hloov xim ntawm cov khoom dyed. Hauv kev lag luam pulp thiab ntawv, EDTA thiab nws cov ntsev inhibit lub peev xwm ntawm cov hlau ions los ntawm catalyzing lub disproportionation ntawm hydrogen peroxide (ib tug raug bleaching neeg sawv cev). EDTAS yog siv rau hauv cov khoom siv hluavtaws. EDTAS kuj tseem siv los ua cov tshuaj tiv thaiv corrosion rau carbon steel hauv kev lag luam. Raws li cov tshuaj tiv thaiv coagulant, EDTAS thiab tripotassium ntsev ntawm EDTA feem ntau yog siv.
siv	Ethylenediaminetetraacetic acid (EDTA) yog ib qho aminopolycarboxylic acid thiab hexadentate ligand. Nws chelates nrog hlau ions, tshwj xeeb tshaj yog nrog cations los tsim ib tug octahedral complex. Ethylenediaminetetraacetic acid disodium ntsev (EDTA) yog cov ntshav anticoagulant thiab pab txhawb rau lub pathogenesis ntawm pseudothrombocytopenia. Nws chelates nrog calcium nyob rau hauv cov ntshav thiab inhibits clotting thiab yog ib txwm siv nyob rau hauv kev ntsuam xyuas hematological. Nws txhim kho cov tshuaj tua kab mob ntawm lysozyme. EDTA siv nyob rau hauv chelation kho chelates nrog calcium thiab nyiam dilation ntawm cov hlab ntsha, solubilisation ntawm atheromatous plaques nyob rau hauv atherosclerotic vascular kab mob. EDTA chelation therapy kuj tseem tuaj yeem tiv thaiv los ntawm kev puas tsuaj oxidative thaum cov ntshav thiab lipid peroxidation hauv daim siab fibrosis.
Cov ntaub ntawv	[1] Victor O. Sheffel (2000) Indirect Food Additives and Polymers: Migration and Toxicology. [2] Lanigan RS, Yamarik TA (2002) Daim ntawv kawg ntawm kev soj ntsuam kev nyab xeeb ntawm EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, thiab trisodium EDTA, HEDTA, Int J Toxicol., 21, 95-142
Chemical Properties	Disodium edetate tshwm sim raws li ib tug dawb crystalline, odorless hmoov nrog ib tug me ntsis acidic saj.
Keeb kwm	Endrate Disodium, Bersworth, Asmeskas, 1959
Siv	disodium EDTA yog ib qho tshuaj preservative siv nyob rau hauv ntau ntawm {{0}}.1 mus rau 0.5 feem pua.
Siv	Disodium Dihydrogen EDTA yog ib tug sequestrant thiab chelating tus neeg saib xyuas uas nws lub npe tag yog disodium ethylenediamine tetraacetate. nws yog cov hmoov uas tsis muaj hygroscopic uas tsis muaj xim, tsis muaj ntxhiab, thiab tsis qab los ntawm kev pom zoo siv. Ib qho kev daws 1% muaj ph ntawm 4.3-4.7. Nws yog siv los tswj cov tshuaj tiv thaiv ntawm cov kab hlau uas muaj cov calcium thiab magnesium nrog rau lwm cov organic thiab inorganic Cheebtsam hauv cov zaub mov kom tsis txhob deterioration ntawm cov xim, kev ntxhib los mos, thiab kev loj hlob ntawm precipitates thiab tiv thaiv oxidation. Nws muaj nuj nqi yog piv rau cov disodium calcium edta.
Siv	Chelating tus neeg sawv cev (hlau); tshuaj pab (chelation agent).
Siv	Ethylenediaminetetraacetic acid disodium ntsev yog dav siv hauv kev lag luam textile. Feem ntau siv rau dissolve limescale. Nws yog siv nyob rau hauv textile kev lag luam, pulp thiab ntawv kev lag luam thiab kuj nyob rau hauv chelation kho. Hauv tshuaj pleev ib ce, nws ua raws li tus neeg sawv cev sequestering. Nws ua raws li kev tiv thaiv corrosion rau carbon steel hauv kev lag luam. Nws kuj ua raws li cov khoom noj ntxiv.
Txhais	ChEBI: Ib qho organic sodium ntsev uas yog daim ntawv anhydrous ntawm disodium ntsev ntawm ethylenediaminetetraacetic acid (EDTA).
Daim ntawv thov	Ethylenediaminetetraacetic acid disodium ntsev dihydrate tau nyob rau hauv noob germination sim ntawm cov nroj tsuag hom thiab nyob rau hauv protein extraction los ntawm Moss, Physcomitrella paten. Nws kuj tau siv rau hauv lysis thiab vacuole tsis rau kev sib cais ntawm vacuoles los ntawm Petunia petals. Chelator ntawm divalent cations. Inhibits enzymes, xws li metalloproteases, uas yuav tsum tau divalent cations rau kev ua si.
Txoj kev tsim khoom	Disodium edetate tuaj yeem npaj los ntawm cov tshuaj tiv thaiv ntawm edetic acid thiab sodium hydroxide.
Kev tsim khoom	10 mols ntawm ethylene diamine li 30% aqueous tov thiab 4 mols ntawm cov khoom caustic soda yog muab tso rau hauv ib lub rhuab boiled kettle muab nrog ib tug agitator. 8 mols ntawm sodium cyanide raws li ib tug concentrated dej tov (kwv yees li 30%) yog ntxiv thiab cov tshuaj rhuab mus rau 60 degree. Kwv yees li 10 nti nqus tsev vacuum yog siv los nqa cov kua rau incipient boiling. Formaldehyde (7.5 mols ntawm 37% mus rau 40% aqueous tov) yog maj mam ntxiv, qhov kub thiab txias tau tuav ntawm 60 degree, thiab cov tshuaj nquag nplawm. Tom qab ntawd, thaum lub evolution ntawm ammonia tau nres, ib qho ntxiv 8 mols ntawm sodium cyanide, ua raws li 8 mols ntawm formaldehyde ntxiv raws li ua ntej. Qhov no txuas ntxiv mus txog 40 mols ntawm cyanide thiab 40 mols ntawm formaldehyde tau ntxiv. Tom qab ntawd thaum kawg txog 2 mols ntau ntawm formaldehyde ntxiv, ua 42 mols hauv tag nrho, kom tshem tawm cov kab kawg ntawm cyanide. Txog 8 mus rau 10 teev yuav tsum tau ua kom tiav cov tshuaj tiv thaiv. Cov khoom uas tshwm sim, raug xa mus rau qhov no raws li cov khoom siv tshuaj tiv thaiv tsis zoo, yog qhov tseem ceeb ntawm cov tshuaj aqueous ntawm sodium ntsev ntawm ethylene diamine tetracetic acid. Rau 1, 000 g ntawm cov tshuaj tiv thaiv crude yog ntxiv 264 g ntawm ethylene diamine tetracetic acid. Cov sib tov yog nyiam dua rhuab rau incipient boiling kom nce tus nqi ntawm cov tshuaj tiv thaiv, thiab ces cov sib tov yog tso cai rau txias thiab crystallize. Cov muaju tsim tau lim tawm, ntxuav nrog qhov tsawg tshaj plaws ntawm cov dej khov dej, thiab qhuav kom qhov hnyav tas li, uas yog 452 g. Ib qho piv txwv ntawm cov khoom lag luam tau npaj tau pom, raws li kev tshuaj xyuas, 13.26% sodium tawm tsam qhov theoretical ntawm 13.70% rau cov ntsev disodium. Cov ntsev dialkali muaj pH txog 5.3 thiab coj zoo li cov kua qaub tsis muaj zog, tshem CO2 ntawm carbonates thiab ua rau cov hlau ua hydrogen. Nws yog dawb crystalline khoom.
Hom lub npe	Endrate (Hospira); Sodium Versenate (3M Pharmaceuticals).
Kev kho mob muaj nuj nqi	Pharmaceutic aid (chelating agent)
Kev piav qhia dav dav	Ethylenediamine tetraacetate (EDTA) yog calcium ion chelator, uas muaj qhov tsis tshua muaj molecular loj ntawm 292.24 Da.
Flammability thiab Explosibility	Tsis yog nplaim taws
Kev siv tshuaj	Disodium edetate yog siv los ua tus neeg sawv cev hauv ntau hom kev npaj tshuaj, suav nrog tshuaj ntxuav qhov ncauj, tshuaj kho qhov muag, thiab tshuaj pleev ib ce, feem ntau ntawm qhov ntau ntawm {{0}}}.005 thiab 0.1% w/v. Disodium edetate cov ntaub ntawv ruaj khov dej-soluble complexes (chelates) nrog alkaline ntiaj teb thiab hnyav-hlau ions. Daim ntawv chelated muaj ob peb yam khoom ntawm cov ion dawb, thiab vim li no cov neeg ua haujlwm chelating feem ntau tau piav raws li 'tshem' ions los ntawm kev daws, txheej txheem hu ua sequestering. Kev ruaj ntseg ntawm cov hlau-edetate complex yog nyob ntawm cov hlau ion koom nrog thiab pH. Disodium edetate kuj tseem siv los ua cov dej softener vim nws yuav chelate calcium thiab magnesium ions tam sim no hauv dej. Nws kuj tseem siv tau kho raws li cov tshuaj tiv thaiv coagulant vim nws yuav chelate calcium thiab tiv thaiv cov ntshav coagulation hauv vitro. Concentrations ntawm {{0}}.1% w/v yog siv nyob rau hauv me me ntim rau hematological kuaj thiab 0.3% w/v nyob rau hauv cov ntshav.
Biochem/physiol Actions	Ethylenediaminetetraacetic acid disodium ntsev muaj peev xwm los thaiv kev khi ntawm vasoactive plab hnyuv peptide rau macrophage daim nyias nyias. Nws yog tsuas yog siv rau hauv kev ua kom huv ntawm cov protein, tshem tawm cov cations divalent thiab tseem tiv thaiv kev ua haujlwm ntawm protease.
Kev ruaj ntseg Profile	Tshuaj lom los ntawm intraperitoneal thiab intravenous txoj kev. Mob hnyav los ntawm kev noj tshuaj. Kev sim teratogenic thiab kev ua me nyuam. Cov ntaub ntawv hloov pauv tau qhia. Calcium disodium ntsev ntawm EDTA yog siv los ua tus neeg sawv cev chelating hauv kev kho cov tshuaj lom lead lom. Thaum rhuab mus rau decomposition nws emits pa phem ntawm NOx thiab NasO.
Kev nyab xeeb	Disodium edetate yog siv dav hauv tshuaj pleev, qhov ncauj, thiab parenteral tshuaj formulations; nws yog siv dav hauv tshuaj pleev ib ce thiab khoom noj khoom haus. Disodium edetate thiab edetate calcium disodium yog siv ntau dua thiab ntau yam tshuaj formulations dua li edetic acid. Ob qho disodium edetate thiab edetate calcium disodium yog absorbed tsis zoo los ntawm txoj hnyuv thiab cuam tshuam nrog ob peb yam tsis zoo thaum siv los ua excipients hauv cov tshuaj formulations. Disodium edetate, trisodium edetate, thiab edetic acid tau yooj yim chelate calcium thiab tuaj yeem, hauv cov koob tshuaj loj, ua rau calcium depletion (hypocalcemia) yog siv rau lub sijhawm ntev, lossis yog siv tau sai heev los ntawm kev txhaj tshuaj intravenous. Yog tias siv rau hauv kev npaj rau lub qhov ncauj, lawv tuaj yeem tso calcium los ntawm cov hniav. Txawm li cas los xij, edetate calcium disodium tsis chelate calcium. Disodium edetate yuav tsum tau siv nrog ceev faj hauv cov neeg mob lub raum tsis zoo, mob ntsws, thiab lub plawv tsis ua haujlwm. Txawm hais tias disodium edetate feem ntau suav hais tias muaj kev nyab xeeb, muaj cov lus ceeb toom ntawm disodium edetate toxicity hauv cov neeg mob tau txais kev kho mob chelation. Qhov ntswg formulations uas muaj benzalkonium chloride thiab disodium edetate, ob qho tib si paub tias yog cov khaus hauv zos, tau pom tias tsim cov tshuaj tiv thaiv kab mob, thiab kev tshuaj xyuas microscopic pom tias muaj kev cuam tshuam ntev ntawm cov mucosa los ntawm eosinophils, thiab tshaj tawm atrophy thiab disorganization ntawm epithelium, txawm hais tias cov teebmeem no tau tshwm sim. tom qab ntawd qhia tau tias yuav thim rov qab. Lub koom haum WHO tau teeb tsa kev kwv yees siv tau txhua hnub rau disodium EDTA hauv cov khoom noj txog li 2.5 mg / kg lub cev hnyav. LD50 (mos, IP): 0.26 g/kg LD50 (mos, IV): 0.056 g/kg LD50 (mos, OP): 2.05 g / kg LD50 (Lavbit, IV): 0.047 g/kg LD50 (Lavbit, OP): 2.3 g / kg LD50 (rat, OP): 2.0 g/kg
Veterinary tshuaj thiab kev kho mob	Edetate Disodium (Sodium EDTA) yog ib tus neeg sawv cev chelating uas tseem siv los tiv thaiv cov nyhuv melting ntawm collagenases thiab proteases ntawm cornea. EDTA muaj txiaj ntsig zoo hauv kev tso tseg melting los ntawm inhibition ntawm matrix metalloproteinases, tab sis tsis xav tias yuav muaj txiaj ntsig zoo rau melting los ntawm cov kab mob sib kis. Raws li cov nyhuv ntawm EDTA ntawm metalloproteinases yog thim rov qab, nws yuav tsum tau siv ntau zaus txhua hnub kom ua tau zoo.
khaws cia	Edetate ntsev yog ruaj khov dua edetic acid (saib Edetic acid). Txawm li cas los xij, disodium edetate dihydrate poob dej ntawm crystallization thaum rhuab mus rau 120 degree. Aqueous daws ntawm disodium edetate tuaj yeem ua kom tsis muaj menyuam los ntawm autoclaving, thiab yuav tsum muab cia rau hauv lub thawv tsis muaj alkali. Disodium edetate yog hygroscopic thiab tsis ruaj khov thaum raug ya raws. Nws yuav tsum tau muab khaws cia rau hauv ib lub thawv kaw zoo hauv qhov chaw txias, qhuav.
Kev tsis sib haum xeeb	Disodium edetate coj tus cwj pwm tsis muaj zog acid, tshem cov pa roj carbon dioxide los ntawm carbonates thiab ua rau cov hlau ua hydrogen. Nws yog incompatible nrog muaj zog oxidizing neeg sawv cev, muaj zog puag, hlau ions, thiab hlau alloys.
Txoj Cai Tswjfwm	GRAS teev. Muaj nyob rau hauv FDA Inactive Ingredients Database (inhalations; txhaj tshuaj; ophthalmic npaj; qhov ncauj capsules, kev daws teeb meem, suspensions, syrups, thiab ntsiav tshuaj; qhov quav tshuaj pleev, thiab qhov chaw mos npaj). Muaj nyob rau hauv cov tshuaj nonparenteral thiab parenteral muaj ntawv tso cai hauv UK. Muaj nyob rau hauv Canadian daim ntawv teev cov khoom uas tsis yog tshuaj.

Ethylenediaminetetraacetic acid disodium ntsev Npaj Cov Khoom Siv Thiab Cov Khoom Siv

Cov khoom siv raw	Sodium hydroxide-->Sodium cyanide-->Formaldehyde-->Ethylenediamine
Cov khoom npaj	ribonucleic acid for injection-->Calcium disodium edetate dihydrate

Cim npe nrov: Tuam Tshoj ethylenediaminetetraacetic acid disodium ntsev, Tuam Tshoj ethylenediaminetetraacetic acid disodium ntsev manufacturers, lwm tus neeg, Hoobkas

Tug: Sodium Edetate

Tom ntej: Tsis muaj

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