Khoom

Tsev / Khoom/ Tshuaj Reagents / Organic Reagents

1,1,1,3,3,3-Hexafluoro-2-propanol

Xa kev nug

Khoom Taw qhia

1,1,1,3,3,3-Hexafluoro-2-propanol Cov ntaub ntawv yooj yim

Kev piav qhia Kev Kho Mob Daim Ntawv Thov Kev Nyab Xeeb Kev Npaj

Khoom npe:	1,1,1,3,3,3-Hexafluoro-2-propanol
Synonyms:	1,1,1,3,3,3-hexafluoro-2-propano;1,1,1,3,3,3-hexafluoro-2-propanolakahfip, hexafluoroisopropanol;JACS{ {14}};Sevoflurane USP Related Compound C; 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL, 99.8+ %;Hexafluoroisopropanol, 99.5%;1, 1,1,3,3,3-Hexafluoro-2-propanol, 10% hauv dichloromethane, rau peptide synthesis; 1,1,1,3,3,3-Hexafluoro{{40} }propanol, rau peptide synthesis, 99.8%
CAS:	920-66-1
MF:	C3H2F6O
MW:	168.04
EINECS:	213-059-4
Khoom Categories:	1,2, 4-Triazole, Triazoles; Organics; Fluoro-Aliphatics; Organic Fluorides; Fluoro series; Cawv; organofluorine compounds; Tsev Blocks; C2 rau C6; Tshuaj Synthesis; Organic Building Blocks; Oxygen Compounds; Acylation Reagent; 920-66-1; Apinno
Mol File:	920-66-1.mol

1,1,1,3,3,3-Hexafluoro-2-propanol Cov Khoom Siv Tshuaj

Melting point	-4 degree (lit.)
Boiling point	59 degree (lit.)
ceev	1.596 g / mL ntawm 25 degree (lit.)
vapor siab	269 hPa (30 degree)
Refractive Index	n20 / D 1.275 (lit.)
Fp	4,4 degree
cia temp.	Khaws hauv qab +30 degree .
solubility	Soluble hauv Chloroform, Ethyl Acetate
pka ua	pK1: 9.42 (25 degree)
daim ntawv	Khoom
Specific Gravity	1.596
xim	Dawb rau daj
PH	3-4 (H2O)Aqueous tov
Dej Solubility	1000 g/L (25 ºC)
lw max	229nm (lit.)
BRN	1841007
Kev ruaj ntseg:	ruaj khov. Incompatible nrog muaj zog acids, muaj zog hauv paus, alkali hlau.
InChIKey	BYEAHWXPCBROCE-UHFFFAOYSA-N
LogP	1.5 ntawm 25 degree
Ntog nro	67.1mN / m ntawm 1g / L thiab 19.8 degree
CAS DataBase Reference	920-66-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
EPA Tshuaj Registry System	1,1,1,3,3,3-Hexafluoro-2-propanol (920-66-1)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	C, Xis
Risk Statements	20/22-34
Cov lus hais txog kev nyab xeeb	26-36/37/39-45-27
RIDADR	UN 2922 8/PG 2
WGK Germany	2
RTECS	UB 6450000
F	27
Ceeb toom	Corrosive
TSCA	T
HazardClass	8
PackingGroup	II
HS Code	29055910
Toxicity	LD50 qhov ncauj hauv luav: 1500 mg / kg

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
1,1,1,3,3,3-Hexafluoro-2-propanol	Lus Askiv
ACROS	Lus Askiv
SigmaAldrich	Lus Askiv
ALFA	Lus Askiv

1,1,1,3,3,3-Hexafluoro-2-propanol Siv Thiab Synthesis

Kev piav qhia	Hexafluoroisopropanol (HFIP) yog cov kua nplaum thiab tsis muaj xim uas tsis muaj ntxhiab tsw txaus ntshai. Nws yog cov kuab tshuaj zoo tshaj plaws rau dissolving polyamides thiab esters, thiab nws tuaj yeem siv los txheeb xyuas cov nylon. Feem ntau, ib qho me me ntawm sodium trifluoroacetate tuaj yeem muab ntxiv rau qhov eluent kom txo cov kev sib sau ntawm cov qauv. HFIP muaj qee qhov viscosity, tab sis nws cov ntsiab lus kub yog qis heev, yog li peb yuav tsum tau soj ntsuam nyob rau hauv cov xwm txheej ntawm 40 degree C kom txo qis sab nraub qaum. Hexafluoroisopropanol kuj tseem yog cov kuab tshuaj hnyav heev uas ua rau muaj qhov tsis yog-linearity ntawm calibration nkhaus tau los ntawm cov kab ke sib xyaw ua ke. Yog li ntawd, Agilent tau tsim ib kem tshwj xeeb-PL HFIPgel kem rau cov kuab tshuaj no, uas muaj cov qauv ntxeem tau uas tsis cuam tshuam los ntawm cov kuab tshuaj.
Daim ntawv thov kho mob	Hexafluoroisopropanol (1,1,1,3,3,3-Hexafluoro-2-propanol) tuaj yeem siv los npaj ntau yam tshuaj zoo xws li fluorosurfactants, fluorine-muaj emulsifiers, tshuaj muaj fluorine. , thiab siv los ua cov kuab tshuaj lossis tshuaj ntxuav tes rau kev lag luam hluav taws xob. Cov tshuaj tuaj yeem siv los ua cov kuab tshuaj fluorinated los ua kom cov tshuaj tiv thaiv ntawm rhodium (I)-catalyzed [4 + 2] intramolecular ntxiv cov tshuaj tiv thaiv ntawm ether khi alkynyl diene thiab [5 + 2] cycloaddition ntawm alkynyl. vinyl cyclopropane. Cov tshuaj yog kua peptide tshuaj hnyav, ib qho hnyav heev rau peptide thiab peptide intermediates. Cov tshuaj tuaj yeem siv rau kev tsom xam ntawm ntau yam polymers.
Kev phom sij	1,1,1,3,3,3-Hexafluoro-2-propanol muab tau los ntawm propan-2-ol. Nws yog cov kua ntshiab uas tsis muaj xim oily nrog cov ntxhiab tsw. (NTP, 1992) Combustible, tej zaum yuav ua rau kub hnyiab ntawm daim tawv nqaij, qhov muag thiab mucous daim nyias nyias.
Kev npaj	1,1,1,3,3,3-Hexafluoro-2-propanol yog npaj los ntawm hexafluoropropylene los ntawm hexafluoroacetone, uas yog tom qab ntawd hydrogenated. (CF3)2CO + H2 → (CF3)2CHOH
Kev piav qhia	1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is aclear, colorless, oily, combustible liquid. Odor is describedasaromatic. Molecular weight = 1 68.04; Specific grav-ity = 1.596 .at 20℃; Freezing/Melting point= -4℃;Boiling point = 59℃at 760 mmHg; V apor pressure:556 mmHg at 51℃; 1468 mmHg at 75℃; Flash point: .>93 degree. Kev txheeb xyuas qhov phom sij (raws li NFPA-704 MRating System): Kev Noj Qab Haus Huv 3; Flammability 0; Reactivity 0.W ater soluble; solubility= Ntau dua lossis sib npaug li 100 mg/mL ntawm 20 degree .
Chemical Properties	1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) yog cov kua ntshiab, tsis muaj xim, oily, combustible kua. Cov ntxhiab yog piav raws li aromatic.
Chemical Properties	Cov kua dej tsis muaj xim
Siv	Hexafluoroisopropanol yog siv los tsim cov tshuaj high-end, xws li fluorinated surfactants, fluorinated emulsifier thiab fluorinated tshuaj, thiab lwm yam. HFIP yog siv los ua cov kuab tshuaj los yog tshuaj ntxuav hauv kev lag luam hluav taws xob.
Siv	1,1,1,3,3,3-Hexafluoro-2-propanol cuam tshuam lub xeev ntawm cov proteins, denaturing lawv nrog rau stabilizing -helical conformation ntawm unfolded proteins thiab polypeptides.
Siv	Nws yog siv los ua cov kuab tshuaj polar thiab nthuav tawm cov khoom muaj zog hydrogen bonding.Nws dissolves cov khoom uas yog hydrogen-daim ntawv cog lus lees txais, xws li amides, ethers thiab ntau hom polymers, nrog rau cov uas tsis soluble hauv cov organic solvents feem ntau.
Siv	Feem ntau siv rau kev npaj hexafluoroalcohol-functionalized methacrylate polymers rau lithographic / nanopatterning cov ntaub ntawv.
Txhais	ChEBI: Ib qho organofluorine compound tsim los ntawm kev hloov ntawm tag nrho cov methyl protons hauv propan-2-ol los ntawm fluorine. Nws yog ib qho metabolite ntawm inhalation anesthetic sevoflurane.
Kev piav qhia dav dav	1,1,1,3,3,3-Hexafluoro-2-propanol yog cov tshuaj peptide chemistry hnyav. Qhov no fluorinated polar hnyav ntawm lub zog ionizing siab pab txhawb Friedel-Crafts-hom tshuaj tiv thaiv, siv covalent reagents thaum tsis muaj Lewis acid catalyst. Nws kuj tseem txhim khu kev ua haujlwm ntawm rhodium(I)-catalyzed [4+2] intramolecular cycloaddition ntawm ether-tethered alkynyl dienes thiab [5+2] cycloaddition ntawm alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol pawg catalyzes epoxidation ntawm cyclooctene thiab 1-octene nrog hydrogen peroxide.
Cua & Dej Reactions	Dej soluble.
Reactivity Profile	1,1,1,3,3,3-Hexafluoro-2-propanol yog incompatible nrog acids, acid chlorides thiab oxidizing agents.
Hluav Taws Xob	1,1,1,3,3,3-Hexafluoro-2-propanol yog tej zaum combustible.
Ntxim yuav nphav raug	Ib qho tshwj xeeb hnyav rau qee qhov poly mers; ib tug lavatory reagent.
Kev pab thawj zaug	Qhov muag: Tshawb xyuas tus neeg raug tsim txom rau cov lo ntsiab muag thiab tshem tawm. Ntxuav cov neeg raug tsim txom ob lub qhov muag nrog dej los yog ib txwm salinesolution rau 20- 30 min, qee zaus nqa daim tawv muag qis thiab sab sauv. Tshem tawm cov khaub ncaws thiab khau uas muaj kab mob. Tau txais kev kho mob tam sim ntawd. Tsis txhob muab tshuaj pleev, roj, lossis tshuaj rau hauv tus neeg mob lub qhov muag yam tsis muaj cov lus qhia tshwj xeeb los ntawm tus kws kho mob. Tam sim ntawd thauj tus neeg raug tsim txom tom qab ntxuav qhov muag mus rau hauv tsev kho mob txawm tias tsis muaj tsos mob (xws li liab lossis khaus khaus) tshwm sim. Daim tawv nqaij: Tam sim ntawd dej nyab cov tawv nqaij nrog dej thiab ntxuav kom tsawg li 15 feeb. Tshem tawm thiab cais tag nrho cov khaub ncaws uas kis kab mob. Maj mam ntxuav txhua qhov chaw ntawm daim tawv nqaij thor-oughly nrog xab npum thiab dej. Yog tias cov tsos mob xws li rednessor khaus tshwm sim, tam sim ntawd hu rau tus kws kho mob.Transportthevictim mus rau lub tsev kho mob fortreatment.Inhalation: Tshem tawm cov neeg raug tsim txom los ntawm huab cua ntshiab. Yog tias tsis ua pa, ua pa tawm dag zog. Yog tias ua pa nyuaj, muab oxygen. Tau txais kev kho mob tam sim ntawd. Noj: Tsis txhob ua rau ntuav. Yog tias tus neeg raug tsim txom tsis nco qab thiab tsis hnov qab, muab dej ntau kom dilute cov tshuaj. Tsis txhob muab ib yam dab tsi los ntawm qhov ncauj rau tus neeg tsis nco qab. Yog tias cov tsos mob (xws li hawb pob, hnoos, ua tsis taus pa, los yog kub hnyiab hauv qhov ncauj, caj pas, orchest), hu rau tus kws kho mob. Hauv txhua kis tau txais kev kho mob tam sim ntawd. Yog hais tias tus neeg raug mob convulsing orunconscious, tsis txhob muab dab tsi los ntawm lub qhov ncauj, xyuas kom meej tias .tus neeg raug tsim txom txoj hlab pas qhib thiab nteg tus neeg raug mob rau ntawm nws sab nrog lub taub hau qis dua lub cev.
khaws cia	Xim Code- Dawb kab txaij (khoom cais): Hu rau Hazard; tsis sib xws nrog cov ntaub ntawv hauv solidwhite qeb. Kev ceev faj cia: koj yuav tsum khaws cov tshuaj no hauv lub tub yees thiab khaws cia kom deb ntawm cov khoom siv ox idizing. Khaws cia deb ntawm qhov chaw ntawm qhov hluav taws kub. Cov khaub ncaws tiv thaiv (cov khaub ncaws tiv thaiv tsawg kawg): yog tias Tyvek-typedisposable tiv thaiv khaub ncaws tsis hnav thaum tuav cov tshuaj no, hnav lub tes tsho Tyvek-type taped rau koj hnab looj tes.
Kev xa khoom	UN1760 Corrosive liquids, nos, Hazard class: 8; Cov ntawv lo: 8-Cov khoom siv corrosive.
Txoj Kev Purification	Distil nws los ntawm 3A molecular sieves, khaws qhov nruab nrab feem. Nws tau raug npaj los ntawm kev txo qis hexafluoroacetone hauv tetrahydrofuran (THF), Hauv qhov no, hexafluoropropanol tsim ib qho chaw ruaj khov 1: 1 complex uas distils ntawm 99-100o/760mm (n 25 1.3283), Lub complex yog decomposed los ntawm kev sib xyaw nrog 20% oleum thiab distilling hauv lub tshuab nqus tsev, thiab cov distillate yog redistilled los muab cov ntshiab hexafluoropropan-2-ol nrog b 59o/760mm. 1H NMR qhia qhov sib npaug ntawm 4.52ppm (JH, H 2Hz). Lub benzoyl derivative, [10315-85-2] M 272.1, muaj m 53.9o tom qab crystalllisation los ntawm pentane ntawm -50o, thiab nws IR muaj ntawm 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] Nws muaj peptide solubilising siab heev, ib leeg lossis nrog CH2Cl2 [siv raws li hnyav: Narita li al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] Nws yog CORROSIVE, ua rau mob qhov muag hnyav.
Kev tsis sib haum xeeb	HFIP tsis sib haum nrog cov kua qaub, kua qaub chlorides, thiab oxidizing tus neeg sawv cev.
Pov tseg pov tseg	Tej zaum yuav incinerated. Hauv accor seev cev nrog 40CFR165, ua raws li cov lus pom zoo rau kev pov tseg cov tshuaj tua kab thiab cov ntim tshuaj tua kab. Yuav tsum tau muab pov tseg kom zoo los ntawm kev ua raws li cov lus qhia ntawm pob ntawv lossis los ntawm kev tiv tauj koj lub chaw lis haujlwm hauv cheeb tsam lossis tsoomfwv ib puag ncig, lossis tiv tauj koj lub chaw haujlwm EPA hauv cheeb tsam. Tham nrog cov koom haum tswj hwm ib puag ncig rau kev taw qhia txog kev coj ua pov tseg. Lub tshuab hluav taws xob ntawm cov khoom pov tseg uas muaj cov kab mob no (Ntau dua lossis sib npaug li 100 kg / mo) yuav tsum ua raws li EPA cov cai tswj kev khaws cia, kev thauj mus los, kev kho, thiab kev pov tseg pov tseg.

1,1,1,3,3,3-Hexafluoro-2-propanol Kev Npaj Khoom Thiab Raw Khoom

Cov khoom nyoos	Cyanogen bromide-->2-Propanol, 1,1,1,2,3,3,3-heptafluoro--->2-(TRIMETHYLSILOXY)PENTAFLUOROPROPENE-->Methyl 3,3,3-Trifluoro-2-hydroxy-2-trifluoromethylpropionate-->Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether-->PHENYL FORMATE-->AMMONIUM TRIFLUOROACETATE-->Hexachloroacetone-->Hexafluoroacetone-->Sodium trifluoroacetate
Cov khoom npaj	Sevoflurane-->HEXAFLUOROISOPROPYL TOSYLATE-->TRIS(1,1,1,3,3,3-HEXAFLUORO-2-PROPYL) PHOSPHITE

Cim npe nrov: 1,1,1,3,3,3-hexafluoro-2-propanol, Tuam Tshoj 1,1,1,3,3,3-hexafluoro-2-propanol manufacturers, lwm tus neeg, Hoobkas

Tug: Glycidol

Tom ntej: Hexafluorobisphenol A

Koj Tseem Yuav Zoo Li

Xa kev nug