Khoom Taw qhia
| 3-Chloropropiophenone Cov ntaub ntawv yooj yim |
| Khoom npe: | 3-Chloropropiophenone |
| Synonyms: | 3-CHLORO-1-PHENYL-1-PROPANONE;3-CHLORO-1-OXO-1-PHENYLPROPANE;B-CHLOROPROPIOPENONE;BETA-CHLOROPROPIOPENONE;{{8} }Chloropropiophenone98%;Chloropropiophenone, 98+%;beta-Chloropropiophenone,98+%;3-Chloropropiophenone, tech., 90% |
| CAS: | 936-59-4 |
| MF: | C9H9CLO |
| MW: | 168.62 |
| EINECS: | 213-317-6 |
| Khoom Categories: | Tsev Blocks; C9; Ketones; Carbonyl Compounds; Tshuaj Synthesis; Organic Building Blocks; Aromatics, Impurities, Intermediates; API |
| Mol File: | 936-59-4.mol |
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| 3-Chloropropiophenone Chemical Properties |
| Melting point | 48-50 degree (lit.) |
| Boiling point | 113-115 degree 4 mm Hg (lit.) |
| ceev | 1.1115 (kev kwv yees kwv yees) |
| Refractive Index | 1.5350 (kwv yees) |
| Fp | >230 degree F |
| cia temp. | Inert cua, Chav Kub |
| solubility | Chloroform (me ntsis), Methanol (me ntsis) |
| daim ntawv | Khoom |
| xim | Tawm-dawb mus rau daj ntseg daj |
| Dej Solubility | Insoluble |
| BRN | 2043580 |
| Kev ruaj ntseg: | ruaj khov. Incompatible nrog cov hauv paus muaj zog, muaj zog oxidizing tus neeg sawv cev. |
| CAS DataBase Reference | 936-59-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Propanone, 3-chloro-1-phenyl-(936-59-4) |
| EPA Tshuaj Registry System | 1-Propanone, 3-chloro-1-phenyl- (936-59-4) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xis |
| Risk Statements | 36/37/38 |
| Cov lus hais txog kev nyab xeeb | 37/39-26-24/25 |
| WGK Germany | 3 |
| TSCA | Yog lawm |
| HS Code | 29147000 |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| 3-Chloro-1-phenyl{2}}propanone | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| 3-Kev siv Chloropropiophenone thiab Synthesis |
| Kev piav qhia | 3-Chloropropiophenone yog ib qho chiral compound uas yog siv los ua tshuaj tiv thaiv kev nyuaj siab. Nws yog thawj zaug synthesized nyob rau hauv 1950s thiab tau kawm ntau heev rau nws cov pharmacological teebmeem. Nws yog ib tug racemic sib tov ntawm ob enantiomers, ib tug yog active thiab lwm yam inactive. Cov nquag enantiomer khi rau serotonin receptors thiab inhibits reuptake ntawm serotonin, uas ua rau kom nce qib serotonin. Lub inactive enantiomer tsis khi rau serotonin receptors thiab tsis inhibit reuptake ntawm serotonin. 3-Chloropropiophenone tau pom tias muaj txiaj ntsig zoo thaum noj ntawm qhov zoo tshaj plaws ntawm 5 milligrams ib kilogram lub cev qhov hnyav. |
| Chemical Properties | faintly daj mus rau tan crystalline hmoov |
| Siv | 3-Chloropropiophenone yog ib qho impurity ntawm Fluoxetine (F597100). |
| Siv | 3-Chloropropiophenone tau siv nyob rau hauv asymmetric txo ntawm (S)-3-chloro-1-phenylpropanol siv preheated Candida utilis hlwb immobilized nyob rau hauv calcium alginate gel hlaws dai. Nws kuj tau siv rau hauv cov synthesis ntawm (R)-3-chloro-1-phenyl-1-propanol ntawm asymmetric txo siv nyob rau hauv-situ generated oxazaborolidine catalyst muab tau los ntawm (S)- , -diphenylprolinol. Nws yog ib qho precursor ntawm phenyl vinyl ketone. |
| Synthesis | Ntxiv 3 '-chlorobenzene acetone thiab levorotatory prolinol rau hauv 95% ethanol thiab nplawm; txias tom qab cov tshuaj tiv thaiv kua yog yaj tag nrho; ntxiv cov poov tshuaj borohydride rau hauv cov tshuaj tiv thaiv hauv cov khoom siv, thiab khaws cia kom sov tom qab ntxiv; cua sov cov tshuaj tiv thaiv rau cov tshuaj tiv thaiv reflux, thiab tsom rau cov tshuaj tiv thaiv nyob rau hauv lub siab txo; ntxiv n-hexane rau hauv cov tshuaj tiv thaiv, cua sov, thiab ntxiv cov pa roj carbon monoxide rau kev txuag hluav taws xob thiab decoloration; lim cov tshuaj tiv thaiv, leaching lub ncuav mog qab zib lim los ntawm kev siv ib txwm hexane, thiab sau cov lim dej; crystallizing thiab lim cov filtrate, leaching lub lim ncuav mog qab zib ib zaug nrog n-hexane, thiab ziab hauv lub tshuab nqus tsev kom tau txais 3-Chloropropiophenone. |
| 3-Chloropropiophenone Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw |
| Cov khoom nyoos | (1R)-3-Chloro-1-phenyl-propan-1-ol-->(3-chloroprop-1-ene-1,1-diyl)dibenzene-->1-PHENYL-1-CYCLOPROPANOL-->3-CHLORO-1-PHENYL-1-PROPANOL-->1-Phenyl-2-propen-1-one-->Cinnamyl chloride-->3-Chloropropionyl chloride-->Propiophenone-->Ethyl 3-chloropropionate-->1-Chloro-3-phenylpropane-->Benzene-->Benzoyl chloride-->Ethyl benzoate hmoov |
| Cov khoom npaj | Bathophenanthroline-->3-(3-METHYLPHENYL)PROPIOPHENONE-->2-(Phenylcarbonyl)ethylboronic acid pinacol ester |
Cim npe nrov: 3-chloropropiophenone, Tuam Tshoj 3-chloropropiophenone manufacturers, lwm tus neeg, Hoobkas
Tom ntej: 2,4'-Dibromoacetophenone
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