Khoom Taw qhia
| (R)-(-)-Benzyl glycidyl ether Cov ntaub ntawv yooj yim |
| Khoom npe: | (R)-(-)-Benzyl glycidyl ether |
| Synonyms: | (R)-(-)-BENZYL GLYCIDYL ETHER;(R)-BENZYL GLYCIDYL ETHER;(R)-BENZYLOXYMETHYL-OXIRANE;RARECHEM AK HZ 0049;(R)-(-)-2-(BENTHYLOX);YE (R)-(-)-1-BENZYLOXY-2,3-EPOXYPROPANE;(R)-1-BENZYLOXY-2,3-EPOXYPROPANE;(r) ) -o-benzylglycidol |
| CAS: | 14618-80-5 |
| MF: | C10H12O2 |
| MW: | 164.2 |
| EINECS: | |
| Khoom Categories: | chiral; API intermediates; CHIRAL COMPOUNDS; Chiral Building Blocks; Glycidyl Compounds, thiab lwm yam. (Chiral); Oxiranes; Yooj yim 3-Nplhaib koom nrog; Synthetic Organic Chemistry; Chiral Compound |
| Mol File: | 14618-80-5.mol |
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| (R)-(-)-Benzyl glycidyl ether Cov Khoom Siv Tshuaj |
| Melting point | 88-93 degree |
| Boiling point | 13 0 degree (0.1 mmHg) |
| alpha | -5.4 º (c{2}} hauv toluene) |
| ceev | 1.077 g / mL ntawm 25 degree (lit.) |
| Refractive Index | n20/D 1.517 (lit.) |
| Fp | >230 degree F |
| cia temp. | 2-8 degree |
| daim ntawv | paste (daj) |
| Specific Gravity | 1.077 |
| xim | Colorless mus Yuav luag tsis muaj xim |
| kev ua haujlwm kho qhov muag | [ ]20/D 5.4 degree , c=5 hauv toluene |
| Dej Solubility | Soluble hauv dej. |
| BRN | 3588399 |
| CAS DataBase Reference | 14618-80-5(CAS DataBase Reference) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xis |
| Risk Statements | 36/37/38 |
| Cov lus hais txog kev nyab xeeb | 26-36-37/39 |
| RIDADR | NA 1993 / PIB |
| WGK Germany | 3 |
| RTECS | TX 2860020 |
| HS Code | 29109000 |
| Toxicity | mic-sat 660 nmol / phaj MUREAV 298,197,1993 |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| (R)-(-)-Benzyl glycidyl ether Siv Thiab Synthesis |
| Chemical Properties | Colorless rau lub teeb daj liqui |
| Siv | Siv nyob rau hauv kev npaj ntawm lactone fragment ntawm compactin thiab mevinolin. Chiron nyob rau hauv kev npaj ntawmsib-1,3-polyols, dideoxynucleosides, thiab spiroacetal cyanohydrin. |
| Synthesis Reference (cov) | Tetrahedron Letters, 21, p. 4807 Ib., 1980DOI: 10.1016/0040-4039(80)80145-6 |
| Kev piav qhia dav dav | 1H-Pyrazol-3-ylboronic acid hydrate tuaj yeem siv los ua cov tshuaj reactant hauv Suzuki-Miyaura coupling cov tshuaj tiv thaiv los ua ke pyrazole derivatives los ntawm reacting nrog txawv aryl halides tshaj lub palladium catalyst. |
| Kev ruaj ntseg Profile | Cov ntaub ntawv hloov pauv tau tshaj tawm. Thaum tshav kub kom decomposition nws emits acrid pa luam yeeb thiab inrritating vapors. |
| Txoj Kev Purification | Cov ether hauv EtOAc no qhuav (Na2SO4), ces purified los ntawm flash chromatography siv tsiaj ether/EtOAc (5:1) raws li eluent. Cov ether distils los ntawm txoj kev luv luv distillation apparatus (Kügelrohr) ua kua tsis muaj xim. Xwb, yaj nws hauv CHCl3, ntxuav nws nrog H2O, qhuav (Na2SO4), evaporate thiab purify los ntawm silica gel chromatography. [Anisuzzamen & Owen J Chem Soc 1021 1967, Takano et al. Heterocycles 1 6 381 1981, Lipshutz et al. Org Synth 69 82 1990, Takano et al. Synthesis 539 1989, Honda et al. Chem Pharm Bull Jpn 39 1385 1991, Beilstein 12 IV 2277.] |
| (R)-(-)-Benzyl glycidyl ether Cov Khoom Npaj Thiab Cov Khoom Siv raw |
| Cov khoom nyoos | Ethyl acetate-->N,N-Dimethylformamide-->PETROLEUM ETHER-->Sodium hydride-->Benzyl bromide-->(S) - Oxiranemethanol |
| Cov khoom npaj | (S)-1-(benzylaMino)-3-(benzyloxy)propan-2-ol-->2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)- |
Cim npe nrov: (r)-(-)-benzyl glycidyl ether, Tuam Tshoj (r)-(-)-benzyl glycidyl ether manufacturers, lwm tus neeg, Hoobkas
Tom ntej: Trans-4-(Trifluoromethyl)cyclohexanol
Koj Tseem Yuav Zoo Li
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