Khoom

3-Amino-1, 2-propanediol

Khoom Taw qhia

3-Amino-1, 2-propanediol Cov ntaub ntawv yooj yim

Khoom npe:	3-Amino-1, 2-propanediol
Synonyms:	3-Aminopropane-1, 2-diol 99%; 3-AMINO-1, 2-PROPANEDIOL 98%; Aminopropylene glycol; 1- Amino-2,3-dihydroxypropane; Isserinol; Glycerol -monoamine;3-Amino-1,2-propanediol,98%;3-Amino{{ 17}}, 2-propanediol (Isoserinol)
CAS:	616-30-8
MF:	C3H9NO2
MW:	91.11
EINECS:	210-475-8
Khoom Categories:	API; Cawv thiab Derivatives; Amino Alcohols; Organic Building Blocks; Oxygen Compounds; 616-30-8
Mol File:	616-30-8.mol

3-Amino-1, 2-propanediol Chemical Properties

Melting point	55-57 degree
Boiling point	264-265 degree 739 mm Hg (lit.)
ceev	1.175 g / mL ntawm 25 degree (lit.)
vapor siab	<1 hPa (20 °C)
Refractive Index	n20/D 1.492 (lit.)
Fp	>230 degree F
cia temp.	Khaws hauv qab +30 degree .
solubility	>1000g / l soluble
daim ntawv	kua (high viscous)
pka ua	12.11 ± 0.35 (Tshaj tawm)
xim	Ntshiab xim tsis muaj xim rau daj ntseg daj
Specific Gravity	1.175
PH	11 (100g / l, H2O, 20 degree)
Dej Solubility	soluble
rhiab heev	Hygroscopic
BRN	1719121
InChIKey	KQIGMPWTAHJUMN-UHFFFAOYSA-N
LogP	-2.079 (yog)
CAS DataBase Reference	616-30-8(CAS DataBase Reference)
NIST Chemistry Reference	3-Amino-1, 2-propanediol (616-30-8)
EPA Tshuaj Registry System	1,2-Propanediol, 3-amino- (616-30-8)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	C, Xis
Risk Statements	34-36/37/38
Cov lus hais txog kev nyab xeeb	26-36/37/39-45-36
RIDADR	UN 2735 8/PG 2
WGK Germany	2
RTECS	TSI 2800000
F	10-21
Ceeb toom	Corrosive
TSCA	Yog lawm
HazardClass	8
PackingGroup	III
HS Code	29221980
Toxicity	LD50 qhov ncauj hauv Luav: 7500 mg / kg

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
1-Amino-2, 3-propanediol	Lus Askiv
SigmaAldrich	Lus Askiv
ACROS	Lus Askiv
ALFA	Lus Askiv

3-Amino-1, 2-propanediol Siv Thiab Synthesis

Kev piav qhia	3-Amino-1,2-propanediol (APD) yog calcium metabolism regulator pab tau nyob rau hauv kev kho mob ntawm Paget tus kab mob, qog-induced hypercalcemia thiab lwm yam pob txha mob uas muaj feem xyuam rau cov kev ua si osteoclastic.
Chemical Properties	3-Amino-1,2-propanediol yog cov kua nplaum heev pob tshab tsis muaj xim rau cov kua daj daj nrog lub melting point ntawm 55-57 degree thiab qhov kub ntawm 264-265 degree . Qhov ceev ntawm 25 degree yog 1.175 g / mL. soluble hauv dej.
Keeb kwm	Henkel (W. Germany)
Siv	3-Amino-1,2-propanediol yog siv rau hauv kev npaj ntawm iohexol, uas yog X-CT uas tsis yog-ionic sib piv nruab nrab. Nws ua raws li cov khoom pib hauv kev tsim cov khoom tshwj xeeb.
Daim ntawv thov	3-Amino-1, 2-propanediol yog siv los ua cov tshuaj reactant nyob rau hauv cov synthesis ntawm lipid-zoo li tus me nyuam molecules (lipidoids) rau RNA cuam tshuam (RNAi) kho. Nws kuj tseem siv rau hauv kev sib txuas ntawm cov qauv bioactive los npaj cationic -helical polypeptides thiab ntau yam cationic polymers rau kev xa cov noob. Nws kuj tseem siv rau hauv kev sib txuas ntawm Decarbazolyl Carvedilol (D212720), ib qho metabolite ntawm Carvedilol (C184625) pom nyob rau hauv tib neeg, nas, dev thiab nas.
Kev npaj	3-Amino-1,2-propanediol yog synthesized los ntawm reacting 3-chloro-1,2-propanediol (CPD) nrog ammonia nyob rau hauv alkaline ib puag ncig los ntawm kev ntxiv sodium hydroxide. Tom qab ntawd, cov khoom tau dhau los ua cov kauj ruam ua kom huv.
Daim ntawv thov	3-Amino-1, 2-propanediol yog siv los ua chiral selector ligand, siv tom qab rau kev hloov pauv nucleophilic nrog dimethoxytrityl (DMT)-tiv thaiv.
Hom lub npe	Aminomux
Kev piav qhia dav dav	3-Amino-1, 2-propanediol yog chiral glycerol derivative. Nws tuaj yeem siv los ua tus neeg pub nyiaj hydrogen hauv kev tsim qauv tshiab sib sib zog nqus eutectic hnyav uas tau tshwm sim los ua lwm txoj hauv kev tsim nyog rau VOCs (volatile organic compounds) rau ntau hom kev siv suav nrog, ntawm lwm tus, kev xa tshuaj, electrochemistry, khoom tsim, extractions thiab , tau kawg, cov tshuaj tiv thaiv organic, ib leeg los yog ua ke nrog lwm cov tshuaj tiv thaiv kev ruaj ntseg-media[1]. Nws kuj tseem siv tau los ua ib qho tseem ceeb hauv cov tshuaj tiv thaiv kab mob rau cov pob txha los tsim cov chav kawm tshiab ntawm cov tshuaj tiv thaiv adenovirus[2].
Hazard	3-Amino-1, 2-propanediol yog Danger. H314 (93.33%): Ua rau tawv nqaij kub hnyiab thiab qhov muag puas tsuaj [Danger Skin corrosion/irritation] H318 (56.36%): Ua rau qhov muag loj heev [Danger Loj qhov muag puas / qhov muag khaus]
Kev ruaj ntseg Profile	Tshuaj lom los ntawm intraperitoneal txoj. Thaum rhuab todecomposition nws tawm cov pa phem ntawm NOx.
khaws cia	3-Amino-1, 2-propanediol absorbs noo noo thiab yuav tsum tau khaws cia rau hauv lub thawv kaw. Khaws rau hauv qhov chaw txias, qhuav hauv cov thawv ntim khoom zoo.
Cov ntaub ntawv	[1] Antenucci A, et al. Kev Tsim Kho Tshiab Chiral Deep Eutectic Solvent Raws li 3-Amino-1, 2-propanediol thiab Nws Daim Ntawv Thov hauv Organolithium Chemistry. Molecules, 2022; 27. [2] Mazzotta S, et al. Tsim, kev sib txuas thiab kev ntsuam xyuas hauv vitro lom ntawm cov chav kawm tshiab ntawm cov tshuaj tiv thaiv adenovirus raws li 3-amino-1, 2-propanediol. Bioorganic Chemistry, 2021; 114: 105095 IB.