Khoom

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Khoom Taw qhia

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Cov ntaub ntawv yooj yim

Khoom npe:	Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms:	(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-(-)- ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(S)-4-CYANO-3-HYDROXYBUTANOETH; (3R)-4-CYANO-3-HYDROXY-BUTANOATE; ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE; ETHYL (R)-4-CYANO-3- HYDROXYBUTANOATE
CAS:	141942-85-0
MF:	C7H11NO3
MW:	157.17
EINECS:	430-220-6
Khoom Categories:	Atorvastatin intermediates; chiral; Cawv, Hydroxy Esters thiab Derivatives; Chiral Compounds; INTERMEDIATESOFATORVASTATIN; API intermediates; Pharmaceutical Intermediates; 141942-85-0
Mol File:	141942-85-0.mol

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties

alpha	-5 º (zoo)
Boiling point	270 degree (lit.)
ceev	1.114 g / ml ntawm 25 degree (lit.)
Refractive Index	n20/D 1.448 (lit.)
Fp	>230 degree F
cia temp.	2-8 degree
solubility	Chloroform (Sparingly), DMSO (me ntsis), Methanol (me ntsis)
pka ua	13. {2}}3 ± 0.20
daim ntawv	Ua kua
Specific Gravity	1.114
xim	Colorless rau daj
kev ua haujlwm kho qhov muag	[ ] 25 / D 5 degree, zoo huv si
BRN	5328715
InChIKey	LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference	141942-85-0(CAS DataBase Reference)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	Xis
Risk Statements	36/37/38
Cov lus hais txog kev nyab xeeb	26-36
WGK Germany	1
HS Code	29269090

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
SigmaAldrich	Lus Askiv
ALFA	Lus Askiv

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Siv Thiab Synthesis

Chemical Properties	kua daj
Siv	analgesic, antipyretic, thiab anti-inflammatory
Siv	(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester yog siv rau hauv cov txheej txheem biocatalytic rau kev sib txuas ntawm atorvastatin intermediate thiab degreedation khoom / impurities.
Daim ntawv thov	Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors yog ib chav kawm tshiab ntawm cov tshuaj txo qis lipid, thiab lawv muaj kev lag luam feem ntau tshaj 10 billion US dollars nyob rau hauv cov chaw muag tshuaj tam sim no. Lawv tuaj yeem xaiv inhibit tus nqi-txheej enzyme HMG-CoA reductase hauv cov roj cholesterol synthesis hauv daim siab, txo cov lipoprotein ntau lawm hauv siab, thiab ua rau kom muaj cov lipoprotein tsawg-density lipoprotein (LDL) cholesterol receptors, yog li txo qis cov roj cholesterol. Lawv kuj tseem tuaj yeem txo qis lipoprotein tsawg heev (VLDL) thiab triglycerides, thiab ua rau muaj kev tiv thaiv atherosclerotic high-density protein (HDL), tiv thaiv atherosclerosis thiab kab mob plawv. Ethyl (R)-(-)-4-cyano-3-hydroxybutyate yog ib qho tseem ceeb nruab nrab rau kev sib txuas ntawm HMG-CoA reductase inhibitors. Yog tias nws yog siv los ua cov khoom siv raw, hluavtaws atorvastatin feem ntau yog siv rau kev kho mob hypercholesterolemia thiab sib xyaw hyperlipidemia, kab mob plawv thiab mob stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw

Cov khoom nyoos	Butanoic acid, 4-cyano-3-hydroxy-, (3R)--->Ethyl 4-bromo-3-hydroxybutyrate-->Sodium cyanide-->Ethanol-->Ethyl 4-chloroacetoacetate
Cov khoom npaj	(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

Cim npe nrov: ethyl (r)-(-) -4-cyano-3-hydroxybutyate, Tuam Tshoj ethyl (r)-(-)-4-cyano-3-hydroxybutyate manufacturers, lwm tus neeg, Hoobkas

Tug: Tsis muaj

Koj Tseem Yuav Zoo Li

Xa kev nug