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Tsev / Khoom/ Tshuaj Reagents / Organic Reagents
Olivetol

Olivetol

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Khoom Taw qhia

 
Olivetol Basic cov ntaub ntawv
Khoom npe: Olivetol
Synonyms: 5-PENTYLRESORCINOL;5-PENTYL 1,3-BENZENEDIOL;5-N-PENTYLRESORCINOL;5-AMYL RESORCINOL;3,5-dihydroxyamylbenzene; AURORA KA -7378;OLIVETOL;Olivetol(3,{11}}hydroxypentylbenzene)
CAS: 500-66-3
MF: C11H16O2
MW: 180.24
EINECS: 207-908-8
Khoom Categories: API intermediates; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; 500-66-3
Mol File: 500-66-3.mol
Olivetol Structure
 
Olivetol Chemical Properties
Melting point 46-48 degree (lit.)
Boiling point 164 degree
ceev 1. 068 ± 0.06 g/cm3
Fp >230 degree F
cia temp. Khaws nyob rau hauv qhov chaw tsaus, inert cua, chav tsev kub
solubility Chloroform (me ntsis), Methanol (me ntsis)
daim ntawv Khoom
pka ua 9.59 ± 0.10 (Tshaj tawm)
xim Tsis muaj xim rau Beige
Kev ruaj ntseg: Lub teeb Sensitive
InChI InChI=1S/C11H16O2/c1-2-3-4-5-9-6-10(12)8-11(13)7-9/h6-8,12-13H,{11 }}H2,1H3
InChIKey IRMPFYJSHJGOPE-UHFFFAOYSA-N
SMILES C1(O)=CC(CCCCCC)=CC(O)=C1
CAS DataBase Reference 500-66-3(CAS DataBase Reference)
NIST Chemistry Reference 1,3-Benzenediol, 5-pentyl-(500-66-3)
EPA Tshuaj Registry System Olivetol (500-66-3)
 
Cov ntaub ntawv kev nyab xeeb
Hazard Codes Xis
Risk Statements 36/37/38
Cov lus hais txog kev nyab xeeb 26-36/39
WGK Germany 3
RTECS VH2880000
HS Code 2907290090
 
MSDS Cov Ntaub Ntawv
Tus kws kho mob Lus
Olivetol Lus Askiv
SigmaAldrich Lus Askiv
 
Kev siv Olivetol thiab Synthesis
Chemical Properties Olivetol yog ib qho dawb dawb crystals los yog txiv ntseej rau lub teeb liab doog waxy khoom. Cov ntaub ntawv monohydrate (lub ntsiab lus melting: 102-106 degree F). Olivetol yog ib tug tswv cuab ntawm chav kawm ntawm resorcinols uas yog resorcinol nyob rau hauv uas hydrogen ntawm txoj hauj lwm 5 yog hloov los ntawm ib pawg pentyl. Nws muaj lub luag haujlwm ua lichen metabolite.
Lub cev muaj zog lub teeb liab mus rau xim av crystalline loj.
Siv Olivetol tau siv los ua tus qauv molecule hauv kev sib txuas ntawm molecularly imprinted polymer (MIP). Nws kuj tau siv los ua ib qho inhibitor ntawm (S)-mephenytoin 4'-hydroxylase kev ua ntawm recombinant CYP2C19.
Daim ntawv thov Olivetol yog ib tug precursor nyob rau hauv ntau yam syntheses ntawm tetrahydrocannabinol.
Kev npaj olivetol kuj tuaj yeem tsim los ntawm hydrolysis ntawm intermediate polyketide CoAs lossis spontaneous cyclization.
synthesis of Olivetol
Txhais ChEBI: Olivetol yog ib tug tswv cuab ntawm chav kawm ntawm resorcinols uas yog resorcinol nyob rau hauv uas cov hydrogen ntawm txoj hauj lwm 5 yog hloov los ntawm ib pawg pentyl. Nws muaj lub luag haujlwm ua lichen metabolite.
Synthesis Reference (cov) Phau ntawv Journal of Organic Chemistry, 42, p. 3456, 1977 ibDOI:10.1021/j00441a036
Kev piav qhia dav dav Olivetol zoo nkaus li tawm-dawb crystals los yog txiv ntseej rau lub teeb liab doog waxy khoom. Cov ntaub ntawv monohydrate (lub ntsiab lus melting: 102-106 degree F). (NTP, 1992)
Cua & Dej Reactions Sensitive rau huab cua. Insoluble hauv dej.
Reactivity Profile Olivetol yog incompatible nrog acid chlorides, acid anhydrides thiab oxidizing neeg sawv cev.
Hluav Taws Xob Olivetol yog tej zaum combustible.
Kev ua lom lom Olivetol (5-Pentylresorcinol, 5-n-Amylresorcinol) yog ib qho tshwm sim ntawm cov organic compound ua ntej nyob rau hauv ntau yam syntheses ntawm tetrahydrocannabinol. Nws ua raws li kev sib tw inhibitor ntawm cannabinoid receptors CB1 thiab CB2.
Kev nyab xeeb Olivetol tseem yog ib yam khoom tshiab heev. Nws tsis tau tshawb fawb ze li txaus los ua pov thawj tias nws muaj kev nyab xeeb siv. Txog tam sim no, tsis muaj leej twg tau tshaj tawm cov kev mob tshwm sim tsis zoo raws li peb paub. Kom txog thaum muaj cov ntaub ntawv ntau ntxiv, ua tib zoo tswj koj qhov kev noj THC es tsis txhob cia siab rau cov gelcap uas tsis tau kuaj.
Hom kev ua Thaum koj saib ntawm olivetol cov qauv molecular, nws yuav zoo li paub. Nws zoo li yog tias ib tug neeg coj THC molecule thiab hlais hauv ob. Olivetol, zoo li THC, ua haujlwm los ntawm kev khi nrog CB1 receptors uas muaj nyob thoob plaws koj lub cev thiab lub hlwb. Tab sis, olivetol tau xav tias me me thiab nplaum dua THC, yog li ntawd pab nws txo qis kev kub ntxhov hauv ob txoj hauv kev. Ua ntej, nws nkag mus rau hauv ib qho qhib receptors ua ntej THC tuaj yeem mus rau ntawd los thaiv lawv-yog li koj yuav tsis tau siab dua. Qhov thib ob, nws tsoo rau THC cov molecules uas twb tau nyob hauv CB1 receptor los khob lawv xoob thiab coj lawv qhov chaw. Qhov ntawd yog li cas nws coj koj nqis.
Raws li ntau tus account tus kheej, olivetol ua haujlwm, tab sis peb tsis paub meej tias nws ua li cas. Kev tshawb fawb thiab kev tshawb fawb ntxiv yog xav tau, tab sis nyob rau hauv txoj kev xav nws zoo ib yam li yuav ua li cas Narcan ua rau thim rov qab opiate overdoses.
 
Olivetol Npaj Cov Khoom Siv thiab Cov Khoom Raw
Cov khoom nyoos Acetic acid-->Sodium-->Government regulation-->Acetone-->Pyridine-->Diethyl malonate-->Sodium dithionite-->Hexanal-->3-Nonen-2-one-->Benzenemethanol, α-butyl-3,5-bis(phenylmethoxy)--->3,5-Bis(benzyloxy)benzoic acid benzyl ester-->methyl 6-n-pentyl-2-hydroxy-4-oxo-cyclohex-2-ene-1-carboxylate-->methyl 2,4-dihydroxy-6-pentylbenzoate-->3,5-Dibenzyloxybenzyl alcohol-->Olivetol Dimethyl Ether-->3,5-Dibenzyloxybenzaldehyde-->3,5-Dihydroxybenzoic acid-->3, 5-DIMETHOXYBENZOYL chloride

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