| Kev piav qhia |
Anisidine muaj xws li ortho-, meta-, thiab paraisomers. Lawv muaj cov yam ntxwv amine (fishy) odors.o-isomer: Cov kua dej tsis muaj xim rau liab. Khoom hauv qab 5 degree .Molecular hnyav= 123.17; Boiling point=224 degree ; Melting / Freezing point=5 degree ; Vapor siab=,0.1 mmHg ntawm 20 degree ; Flash point=118 degree (oc); Autoignition kub=415 degree . Hazard Identification(raws li NFPA-704 M Rating System): Health 2,Flammability 1, Reactivity 0. Xyaum insoluble hauv dej; solubility =1.5%.m-isomer: daj ntseg kua. Molecular hnyav= 123.2; Boiling point= 251 degree ; Txias / Melting point=57.2 degree ; Vapor siab=0.006 mmHg ntawm 20 degree .p-isomer: Reddish-xim av khoom. Molecular hnyav= 123.2; Boiling point= 243 degree ; Txias / Melting point=57.2 degree; Vapor siab: 0.4 mmHg ntawm 20 degree; Flash point=122 degree ; Autoignition kub=515 degree . Kev txheeb xyuas qhov phom sij (raws li NFPA-704 M Rating System): Kev Noj Qab Haus Huv 2, Flammability 0, Reactivity 0. Insoluble hauv dej. |
| Chemical Properties |
Lub teeb daj oily kua uas muaj cov yam ntxwv amine (fishy) tsw. soluble hauv cawv, ether, benzene thiab dilute acid, me ntsis soluble hauv dej. Anisidine muaj xws li ortho-, meta-, thiab paraisomers. |
| Siv |
m-Anisidine yog ib qho tshuaj lom heev monosubstituted aniline siv los ua corrosion inhibitors rau txhuas, tooj liab thiab lwm yam hlau hauv acidic daws. |
| Siv |
Qhov txawv txav ntau ntawm cov khoom dibromo uas tsim los ntawm bromination ntawm m-anisidine tuaj yeem raug ntaus nqi rau ob txoj haujlwm ua haujlwm ob npaug. Qhov zoo tshaj plaws enantioselectivity ntawm 97% ee tau soj ntsuam rau cov tshuaj tiv thaiv ntawm m-anisidine nyob rau hauv organocatalytic asymmetric peb-tivthaiv cyclization ntawm cinnamaldehydes thiab thawj amines nrog 1, 3-Dicarbonyl Compounds. Cov pov thawj rau kev tswj hwm ntawm 2nd-harmonic tiam kev ua ub no los ntawm x-ray siv lead ua-cov qauv ntawm cov complexes ntawm l-tartaric acid nrog m-anisidine thiab p-toluidine tau txiav txim. |
| Daim ntawv thov |
m-Anisidine yog siv rau hauv:
Cov synthesis ntawm N-substituted -3-chloro-2-azetidinones, uas yog cov tshuaj anthelmintic.
Rhodium-catalyzed synthesis ntawm indoles thiab tooj liab-catalyzed synthesis ntawm benzimidazoles.
Hauv kev npaj ntawm azocalix [4] areene dyes. |
| Kev npaj |
m-Aminoanisole yog tsim los ntawm kev txo qis ntawm m-nitrophenol tom qab methylation ntawm pawg hydroxyl.
Ib qho sib tov ntawm 35 g. (0.23 mole) ntawm m-nitroanisole (p. 213), 110 ml. ntawm methanol, thiab 7.5 ml. ntawm concentrated hydrochloric acid yog nplawm thiab rhuab rau boiling. Plaub caug-ob grams (0.75 gram atom) ntawm cov ntaub ntawv hlau yog ntxiv rau hauv me me nyob rau hauv ib lub sij hawm 1- teev, thiab refluxing thiab stirring yog txuas ntxiv rau 5 teev ntxiv. Cov sib tov yog ua kom muaj zog alkaline nrog sodium hydroxide thiab chav-distilled, lub methanol uas thawj distils tshaj raug sau cais. Cov seem ntawm cov distillate yog muab rho tawm nrog ether; ethereal solu-tion yog qhuav dhau anhydrous sodium sulfate thiab distilled. m-Anisidine (23.2 g. lossis 80%) yog sau ntawm 125 degree / 13 mm.
Reference: J. Chem. Soc, 1934, 1420; J. Cheem. Soc, 127, 494 (1925). |
| Txhais |
ChEBI: 3-Methoxyaniline yog hloov pauv aniline thiab muaj ntxhiab ether. |
| Synthesis Reference (cov) |
Phau ntawv Journal of Organic Chemistry, 22, p. 333 Ib., 1957DOI:10.1021/j01354a610
Tetrahedron Letters, 24, p. 4121 Ib., 1983DOI: 10.1016/S0040-4039(00)88277-5 |
| Kev piav qhia dav dav |
M-anisidine zoo li daj ntseg oily kua los yog kua liab liab. (NTP, 1992) |
| Cua & Dej Reactions |
m-Anisidine tej zaum yuav rhiab heev rau lub sij hawm raug rau huab cua thiab lub teeb. Insoluble hauv dej. |
| Reactivity Profile |
m-Anisidine yog incompatible nrog muaj zog oxidizers. m-Anisidine kuj tsis sib haum nrog cov kua qaub, kua qaub chlorides, acid anhydrides thiab chloroformates. |
| Hluav Taws Xob |
m-Anisidine yog tej zaum combustible. |
| Kev ruaj ntseg Profile |
Mob hnyav heev los ntawm ingestion.Mutation cov ntaub ntawv qhia. Thaum rhuab mus rau decomposition itemits lom vapors ntawm NOx. |
| Ntxim yuav nphav raug |
Anisidines yog siv rau hauv kev tsim cov azo dyes; tshuaj; Textile-processing chemicals Incompatibilities: Incompatibilities nrog oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, thiab lwm yam); kev sib cuag tej zaum yuav ua rau hluav taws kub los yog tawg. Khaws kom deb ntawm cov ntaub ntawv alkaline, muaj zog hauv paus, muaj zog acids, oxoacids, epoxides. Tawm tsam qee cov txheej txheem thiab qee cov ntaub ntawv yas thiab roj hmab. |
| Kev pab thawj zaug |
Yog hais tias cov tshuaj no nkag mus rau hauv lub qhov muag, tshem tawm ib qho kev sib cuag lo ntsiab muag ib zaug thiab irrigate tam sim ntawd rau tsawg kawg yog 15 feeb, qee zaus nqa lub hau sab sauv thiab qis dua. Nrhiav kev kho mob tam sim ntawd. Yog tias cov tshuaj no cuam tshuam rau ntawm daim tawv nqaij, tshem tawm cov khaub ncaws tsis huv thiab ntxuav tam sim nrog xab npum thiab dej. Nrhiav kev kho mob Anisidines 231 tam sim ntawd. Yog tias cov tshuaj no tau nqus tau, tshem tawm ntawm qhov raug, pib ua pa cawm siav (siv kev ceev faj thoob ntiaj teb, suav nrog daim npog qhov ncauj resuscitation) yog ua pa tsis ua haujlwm thiab CPR yog tias lub plawv nres. Hloov tam sim ntawd mus rau qhov chaw kho mob. Thaum cov tshuaj no tau nqos lawm, mus kho mob. Muab dej ntau thiab ua kom ntuav. Tsis txhob ua rau tus neeg tsis nco qab ntuav.Ceeb toom rau tus kws kho mob: Kho rau methemoglobinemia.Spectrophotometry tej zaum yuav raug txiav txim siab txog qib ntawm methemoglobinemia hauv cov zis. |
| khaws cia |
Xim Code-Green: Kev khaws cia. Ua ntej ua haujlwm nrog cov tshuaj no koj yuav tsum tau kawm txog nws txoj kev tuav thiab khaws cia. Khaws rau hauv cov thawv kaw nruj nreem rau hauv qhov chaw txias, tsaus, zoo-ventilated. Tiv thaiv tshav ntuj thiab muaj zog oxidizers. Cov thawv hlau uas cuam tshuam txog kev hloov pauv ntawm cov tshuaj no yuav tsum tau ua hauv av thiab sib txuas. Yog tias ua tau, cia li tso kua dej los ntawm lub nruas lossis lwm lub thawv ntim khoom kom ua cov thawv ntim khoom.Drums yuav tsum tau nruab nrog lub kaw lus tus kheej, lub tshuab nqus tsev twj, thiab cov nplaim taws. Siv cov cuab yeej thiab cov cuab yeej uas tsis muaj pa taws, tshwj xeeb tshaj yog thaum qhib thiab kaw cov thawv ntawm cov tshuaj no. Qhov chaw ntawm qhov hluav taws kub, xws li haus luam yeeb thiab qhib nplaim taws, yog txwv tsis pub siv cov tshuaj no, tuav, lossis khaws cia hauv ib qho uas tuaj yeem tsim hluav taws kub los yog tawg. Ib cheeb tsam tswj hwm, cim cim yuav tsum tau tsim qhov twg cov tshuaj no raug muab tshem tawm, siv, lossis khaws cia ua raws li OSHAStandard 1910.1045. |
| Kev xa khoom |
UN2431 Anisidines, Hazard Class: 6.1; Cov ntawv lo: 6.1-Cov khoom muaj kuab lom |
| Txoj Kev Purification |
o-Isomer impurity tuaj yeem raug tshem tawm los ntawm chav distillation. Lwm qhov ua tau impurity yog qhov precursor 3-nitroanisole uas tuaj yeem raug tshem tawm raws li o-isomer ua ntej thiab fractionating siv cov kab ke zoo. Nws yog kua daj. [Gilman & Kyle J Am Chem Soc 74 3027 1952, Bryson J Am Chem Soc 82 4858 1960, Kadaba & Massie J Org Chem 22 333 1957, Beilstein 13 IV 953.] |
| Kev tsis sib haum xeeb |
Tsis sib haum nrog cov oxidizers muaj zog, tiv thaiv hluav taws los yog tawg. Tawm tsam ib co coatings thiab tej yam yas thiab roj hmab. |
| Pov tseg pov tseg |
Dissolve nyob rau hauv combustible hnyav (cawv, benzene, thiab lwm yam) thiab tshuaj tsuag tov rau hauv lub cub tawg nruab nrog afterburner thiab scrubber, los yog hlawv cov seem seem ntawm cov xuab zeb thiab dej qab zib tshauv absorbent nyob rau hauv lub cub tawg. |
