Khoom

Benzethonium Chloride

Khoom Taw qhia

Benzethonium chloride Cov ntaub ntawv yooj yim

Khoom npe:	Benzethonium chloride
Synonyms:	Benzethonium chL; Hoobkas nqi Benzethonium chloride; BENZETHONIUM chloride BIOULTRA; Benzenemethanaminium, N, N-dimethyl-N-[2-[2-[4-(1,1,3,{{9} }}tetramethylbutyl)phenoxy]ethoxy]ethyl]-, chloride, hydrate (1: 1: 1); 2-phenylthyliuM chloride; BENZETHONIUM chloride EP; BenzethoniuM chloride, 97% 100GR; BenzethoniuM 7% chloride,
CAS:	121-54-0
MF:	C27H42ClNO2
MW:	448.08
EINECS:	204-479-9
Khoom Categories:	Anti-virals; Aromatics; Organics; Intermediates & Fine Chemicals; Pharmaceuticals; PHEMERIDE; Ammonium Chlorides (Quaternary); Aromatic Quaternary Ammonium Salts (Surfactants); Cationic Surfactants; Cov Khoom Siv Ua Haujlwm; Quaternary Ammonium Compounds; 1{Surfactants;
Mol File:	121-54-0.mol

Benzethonium chloride Cov Khoom Siv Tshuaj

Melting point	162-164 degree (lit.)
Boiling point	162 degree [ntawm 101 325 Pa]
ceev	0.998 g/mL ntawm 20 degree
vapor siab	< 0.001 hPa @ 2°C
Refractive Index	1.5650 (kwv yees)
cia temp.	2-8 degree
solubility	H₂O: 0.1 M ntawm 20 degree, ntshiab, tsis muaj xim
daim ntawv	Ua kua
xim	Dawb
PH	5.5-7.5 (25 degree, 0.1M hauv H2O)
tsw	Tsis hnov tsw
PH Range	5.5 - 7.5
Dej Solubility	1-5 g/100 mL ntawm 18 ºC
rhiab heev	Hygroscopic
Merck	14,1074
BRN	3898548
Kev ruaj ntseg:	Stability ruaj khov, tab sis hygroscopic. Incompatible nrog muaj zog oxidizing neeg sawv cev, xab npum, anionic detergents, nitrates, acids. Lub teeb rhiab heev.
LogP	1.08 ntawm 20 degree
CAS DataBase Reference	121-54-0(CAS DataBase Reference)
EPA Tshuaj Registry System	Benzethonium chloride (121-54-0)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	Xn, N, C
Risk Statements	22-37/38-41-36-36/37/38-20/21/22-50/53-34-52/53
Cov lus hais txog kev nyab xeeb	26-36/39-24/25-36/37/39-61-45
RIDADR	UN 1759
WGK Germany	2
RTECS	TIAB SA 7175000
F	8
TSCA	Yog lawm
HazardClass	8
PackingGroup	III
HS Code	29239000
Cov Ntaub Ntawv Muaj Xwm Ceev	121-54-0(Cov ntaub ntawv muaj phom sij)
Toxicity	LD50 iv hauv nas: 29.5 mg/kg (Weiss)

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
Benzethonium chloride	Lus Askiv
SigmaAldrich	Lus Askiv
ACROS	Lus Askiv
ALFA	Lus Askiv

Benzethonium chloride Siv Thiab Synthesis

Chemical Properties	Dawb los yog daj-dawb hmoov.
Chemical Properties	Benzethonium chloride tshwm sim raws li cov khoom siv dawb crystalline nrog cov ntxhiab tsw thiab iab heev.
Keeb kwm	Phemerol, Parke Davis, USA, 1942
Siv	benzethonium chloride yog ib qho tshuaj tiv thaiv uas ua haujlwm tawm tsam algae, kab mob, thiab fungi. Hauv kev npaj tu tawv nqaij, nws muaj kev nyab xeeb rau kev siv ntawm qhov ntau ntawm 0.5 feem pua.
Siv	Ib qho hluavtaws quaternary ammonium ntsev nrog surfactant, antiseptic thiab tiv thaiv kab mob. Nws nthuav tawm cov haujlwm microbiocidal tawm tsam ntau yam kab mob, fungi, pwm thiab kab mob. Nws kuj tau pom tias muaj qhov tseem ceeb ntawm kev ua haujlwm tiv thaiv kab mob cancer.
Siv	Nyob rau hauv cov tshuaj pleev ib ce li preservative; cationic surfactant. Raws li tshuaj tua kab mob hauv cov khoom noj mis nyuj thiab zaub mov kev lag luam. Clinical reagent rau kev txiav txim siab ntawm cov protein hauv CSF; tshuaj pab (preservative).
Siv	Benzethonium Chloride USP yog siv los ua cov tshuaj tua kab mob rau cov tshuaj thiab tshuaj pleev ib ce. (USP qib ntawm Hyamine(R) 1622 crystals).
Siv	Lub cationic detergent benzethonium chloride yog ib tug zoo yam ntxwv ntawm daim tawv nqaij irritant thiab tsis tshua muaj sensitizer. Benzethonium chloride tau siv hauv kev tshawb fawb los ntsuas qhov tsawg kawg nkaus inhibitory concentrations ntawm methicillin-resistant Staphylococcus aureus (MRSA) cais tawm ntawm Malaysia. Nws kuj tau siv rau hauv kev tshawb fawb los npaj biocomposite films los ntawm sodium alginate thiab hloov av nplaum.
Siv	Hyamine (R) 1622 Crystals yog FDA lees txais cov khoom siv rau cov tshuaj pleev ib ce. Nws tuaj yeem siv los ua cov kab mob bactericidal, deodorant, lossis ua cov tshuaj tua kab mob hauv ntau daim ntawv thov suav nrog cov neeg saib xyuas tus kheej, kws kho tsiaj thiab tshuaj.
Txhais	ChEBI: Ib (synthetic) quaternary ammonium ntsev uas yog benzyldimethylamine nyob rau hauv uas cov nitrogen yog quaternised los ntawm ib tug 2-{2-[p-(2,4,4-trimethylpentan-2- yl)phenoxy]ethoxy}ethyl pawg, nrog chloride ua tus counter-ion. Ib qho tshuaj tua kab mob thiab tshuaj tua kab mob, nws ua haujlwm tawm tsam ntau yam kab mob, fungi, pwm thiab kab mob.
Txoj kev tsim khoom	p-Disobutylphenol yog condensed nyob rau hauv lub xub ntiag ntawm ib tug yooj yim catalyst nrog , '-dichlorodiethyl ether kom tawm los 2-[2-[4-(1,1,3,3-tetramethylbutyl ) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination ces tsim cov tertiary amine uas, tom qab purification los ntawm distillation, yog yaj nyob rau hauv ib tug haum organic hnyav thiab kho nrog benzyl chloride rau precipitate benzethonium chloride.
Kev tsim khoom	Kev sib xyaw ntawm 32 g ntawm p-( , , , -tetramethylbutyl) phenoxyethoxyethyl dimethylamine thiab 12.7 qhov chaw ntawm benzyl chloride tau sov hauv 50 g ntawm benzene rau 2 teev. Tom qab ntawd cov benzene tau evaporated. Cov residual viscous loj muab ib tug foamy, soapy tov nyob rau hauv dej. Cov khoom pib pib yog p-diisobutylphenol, dichlorodiethyl ether thiab dimethylamine.
Hom lub npe	Microklenz (Carrington); Phemerol Chloride (Parke-Davis).
Kev kho mob muaj nuj nqi	Tshuaj tiv thaiv kab mob
Kev piav qhia dav dav	Tsis hnov tsw dawb crystals los yog hmoov nrog ib tug heev iab saj. Ib qho 1% tov hauv dej yog me ntsis alkaline rau litmus.
Cua & Dej Reactions	Hygroscopic. Tej zaum yuav rhiab heev rau lub sij hawm raug rau huab cua. Dej soluble.
Reactivity Profile	Benzethonium chloride is incompatible with strong oxidizing agents Incompatible with soap and anionic detergents. Can react with nitrates. Sensitive to light. Acids cause Benzethonium chloride to precipitate from aqueous solutions of >2% concentration. ruaj khov rau ob lub lis piam ntawm qhov kub txog li 140 F, .
Hazard	Qhov ncauj tshuaj lom.
Hluav Taws Xob	Cov ntaub ntawv flash point rau Benzethonium chloride tsis muaj. Benzethonium chloride tej zaum combustible.
Flammability thiab Explosibility	Tsis cais
Kev siv tshuaj	Benzethonium chloride yog quaternary ammonium compound siv nyob rau hauv cov tshuaj formulations raws li ib tug antimicrobial preservative. Feem ntau, nws yog siv rau lub hom phiaj no hauv kev txhaj tshuaj, ophthalmic thiab otic npaj ntawm concentrations {{0}}.01–0.02% w/v. Benzethonium chloride kuj tseem siv tau los ua cov ntaub ntub dej thiab solubilizing tus neeg sawv cev, thiab ua cov tshuaj tua kab mob. Hauv cov tshuaj pleev ib ce xws li deodorants, benzethonium chloride tuaj yeem siv los ua cov tshuaj tiv thaiv kab mob microbial hauv ntau txog 0.5% w/v. Lub cev muaj zog thiab kev siv ntawm benzethonium chloride zoo ib yam li lwm cov cationic surfactants xws li cetrimide.
Kev ruaj ntseg Profile	Tshuaj lom los ntawm kev noj tshuaj, subcutaneous, intraperitoneal, thiab txoj hlab ntshav. Asevere qhov muag irritant. Cov lus nug carcinogen nrog cov ntaub ntawv kuaj neoplastigenic. Cov ntaub ntawv hloov pauv tau tshaj tawm.Thaum rhuab mus rau decomposition nws emits cov pa phem heev ntawm Cl^-
Kev nyab xeeb	Benzethonium chloride yog nkag tau yooj yim absorbed thiab feem ntau suav hais tias yog tshuaj lom thaum noj qhov ncauj. Kev noj tshuaj tuaj yeem ua rau ntuav, ntuav, ntuav, thiab coma. Qhov yuav ua rau tib neeg qhov ncauj koob tshuaj yog kwv yees li 50-500 mg / kg lub cev hnyav. Kev siv cov tshuaj pleev ib ce uas muaj ntau dua 5% w / v benzethonium chloride tuaj yeem ua rau khaus txawm tias benzethonium chloride tsis suav tias yog rhiab heev. Kev siv 0.5% w/v benzethonium chloride hauv cov tshuaj pleev ib ce yog txuam nrog ob peb yam tsis zoo. Qhov siab tshaj plaws ntawm 0.02% w/v benzethonium chloride yog pom zoo siv rau hauv cov tshuaj pleev ib ce siv nyob rau hauv lub qhov muag thiab qhov no kuj yog qhov siab tshaj plaws concentration feem ntau siv nyob rau hauv cov tshuaj formulations xws li txhaj tshuaj thiab ophthalmic npaj. Saib kuj Benzalkonium Chloride. LD₅₀(nas, IP): 15.5 mg/kg LD₅₀(nas, IV): 30 mg/kg LD₅₀(nas, qhov ncauj): 338 mg/kg LD₅₀(rat, IP): 16.5 mg/kg LD₅₀(rat, IV): 19 mg/kg LD₅₀(rat, qhov ncauj): 368 mg/kg LD₅₀(rat, SC): 119 mg/kg
khaws cia	Benzethonium chloride yog ruaj khov. Aqueous daws tej zaum yuav sterilized los ntawm autoclaving. Cov khoom siv ntau yuav tsum muab khaws cia rau hauv lub thawv airtight tiv thaiv los ntawm lub teeb, hauv qhov chaw txias, qhuav.
Txoj Kev Purification	Crystallize nws los ntawm boiling acetone tom qab lim los yog los ntawm CHCl3 / tsiaj ether. Lub precipitate yog lim tawm, ntxuav nrog diethyl ether thiab qhuav rau 24 teev nyob rau hauv lub tshuab nqus tsev desiccator. Nws yog cationic antiseptic surfactant uas tsim cov muaju los ntawm 1: 9 MeOH / Et2O sib tov. Nws foams hauv dej. [Beilstein 12 IV 2187.]
Kev tsis sib haum xeeb	Benzethonium chloride yog incompatible nrog xab npum thiab lwm yam anionic surfactants thiab tej zaum yuav precipitated los ntawm cov kev daws teeb meem ntau tshaj 2% w / v concentration los ntawm kev ntxiv cov ntxhia acids thiab ib co ntsev tov.
Kev tswj hwm xwm txheej	Muaj nyob rau hauv FDA Inactive Ingredients Database (IM thiab IV txhaj tshuaj; qhov ntswg, ophthalmic thiab otic npaj). Muaj nyob rau hauv Canadian daim ntawv teev cov khoom uas tsis yog tshuaj.