Khoom Taw qhia
| 3-Amino-1-adamantanol Cov ntaub ntawv yooj yim |
| Khoom npe: | 3-Amino-1-adamantanol |
| Synonyms: | CHEMBRDG-BB 4003530;3-AMINO-1-ADAMANTANOL;3-Amino-1-hydroxyadamantane;3-AMINOADAMANTAN-1-OL;AKOS BB{{8} };1-AMINO-3-ADAMANTANOL;1-AMINO-3-HYDROXYADAMANTANE;3-Hydroxy-1-aminoadamantane |
| CAS: | 702-82-9 |
| MF: | C10H17 Nr |
| MW: | 167.25 |
| EINECS: | 615-098-6 |
| Khoom Categories: | Amino Alcohols; Lub Tsev Blocks; Chemical Synthesis; Organic Building Blocks; Oxygen Compounds; intermediate; Adamantane derivatives; Adamantane; Fused Ring Systems; Amino Alcohols; Organic Building Blocks; Oxygen Compounds; Intermediates & Fine Chemicals; Pharmaceuticals series; Pharmaceuticals ;Amines thiab Anilines; Amines; 702-82-9 |
| Mol File: | 702-82-9.mol |
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| 3-Amino-1-adamantanol Chemical Properties |
| Melting point | 265 degree (lub kaum hli ntuj) (lit.) |
| Boiling point | 266.8 ± 23. 0 degree (Predicted) |
| ceev | 1.252 ± 0.06 g / cm3 (Tshaj tawm) |
| Fp | 230 degree F |
| cia temp. | Khaws nyob rau hauv qhov chaw tsaus, inert cua, chav tsev kub |
| solubility | DMSO (me ntsis), Methanol (me ntsis) |
| daim ntawv | Crystalline hmoov |
| pka ua | 15. |
| xim | Dawb rau daj |
| Dej Solubility | Soluble nyob rau hauv cov organic solvents, insoluble nyob rau hauv dej. |
| InChI | InChI=1S/C10H17NO/c11-9-2-7-1-8(3-9)5-10(12,{7}})6-9/h7-8, 12H,1-6,11H2 |
| InChIKey | DWPITTNBOVJYAD-UHFFFAOYSA-N |
| SMILES | C12(O)CC3CC(CC(N)(C3)C1)C2 |
| CAS DataBase Reference | 702-82-9(CAS DataBase Reference) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xis |
| Risk Statements | 36/37/38 |
| Cov lus hais txog kev nyab xeeb | 26-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29221990 |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| SigmaAldrich | Lus Askiv |
| 3-Amino-1-adamantanol Siv Thiab Synthesis |
| Kev piav qhia | 3-Amino-1-adamantanol yog ib qho tseem ceeb adamantane tshuaj intermediate feem ntau yog siv rau hauv synthesis ntawm inhibitors nrog antihyperglycaemic zog rau kev npaj ntawm Vildagliptin, ib tug dipeptidyl peptidase 4 (DPP-4) inhibitor siv nyob rau hauv lub kev kho mob ntshav qab zib hom 2. |
| Chemical Properties | Dawb khoom |
| Siv | Nws yog siv nyob rau hauv cov synthesis ntawm inhibitors nrog antihyperglycemic zog. vil- dagliptin yog tsim los ntawm 3-Amino-1-adamantanol. |
| Siv | Raws li reagent, 3-Amino-1-hydroxyadamantane tuaj yeem siv rau hauv kev npaj ntawm Vildagliptin. |
| Siv | 3-Amino-1-hydroxyadamantane tuaj yeem ua haujlwm nyob rau hauv kev sib txuas ntawm inhibitors nrog cov khoom siv tshuaj tiv thaiv hyperglycemic. |
| Synthesis | Ib txoj kev npaj ntawm 3-amino-1-adamantanol suav nrog cov kauj ruam hauv qab no: (1) ntxiv amantadine los yog ntsev ntawm no rau sulfuric acid ntawm 10-30 DEG C thiab ntxiv cov kua qaub sib xyaw ua ke los ua ib qho nitration cov tshuaj tiv thaiv kom tau txais cov tshuaj tiv thaiv kua; (2) ntxiv cov tshuaj tiv thaiv rau cov dej thiab sib tov cov tshuaj tiv thaiv cov kua dej kom tau cov tshuaj tov; (3) ua cov tshuaj tiv thaiv hydroxylation nyob rau hauv cov nyhuv ntawm alkaline kom tau txais cov 3-amino-1-adamantanol. Txoj kev npaj siv cov khoom siv raw, yooj yim kom tau, yooj yim hauv kev ua haujlwm, tiv thaiv ib puag ncig, tsis tshua muaj nqi, thiab muaj txiaj ntsig siab, uas feem ntau siab dua 80%, ntau tshaj 90.1%. |
| 3-Amino-1-adamantanol Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw |
Cim npe nrov: 3-amino-1-adamantanol, Tuam Tshoj 3-amino-1-adamantanol manufacturers, lwm tus neeg, Hoobkas
Tug: Tsis muaj
Tom ntej: Diethyl L-glutamate Hydrochloride
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