Khoom Taw qhia
| p-Toluenesulfonamide Cov ntaub ntawv yooj yim |
| Lub luag haujlwm thiab lub hom phiaj Siv cov txheej txheem tsim khoom |
| Khoom npe: | p-Toluenesulfonamide |
| Synonyms: | Tosylamide; Uniplex 173; 4-TOLUENESULFONIC ACID AMIDE; 4-TOLUENESULFONAMIDE; 4-METHYLBENZENESULFONAMIDE; P-TOLUENESULFONAMIDE; P-TOLUENESULFONYLAMIDE;P-TOLUENESULFONAMIDE |
| CAS: | 70-55-3 |
| MF: | C7H9NO2S |
| MW: | 171.22 |
| EINECS: | 200-741-1 |
| Khoom Categories: | Organic Building Blocks; Sulfonamides / Sulfinamides; FINE Chemical & INTERMEDIATES; Sulfur Compounds; Bioactive Me Molecules; Lub Tsev Blocks; SULFONAMIDE; Cell Biology; Tshuaj Synthesis; Organic Building Blocks; Sulfur Compounds; T; Pharmaceutical Qinolines; {0}} |
| Mol File: | 70-55-3.mol |
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| p-Toluenesulfonamide Chemical Properties |
| Melting point | 134-137 degree (lit.) |
| Boiling point | 221 degree (10 mmHg) |
| ceev | 1.2495 (zeeg) |
| vapor ceev | 5.9 (vs huab cua) |
| Refractive Index | 1.6100 (kwv yees) |
| Fp | 202 degree |
| cia temp. | Khaws hauv qab +30 degree . |
| solubility | DMSO: soluble |
| pka ua | 1 0.20 ± 0.10 (Tshaj tawm) |
| daim ntawv | Crystalline hmoov |
| xim | Dawb |
| tsw | Tsis hnov tsw |
| Dej Solubility | 0.32 g / 100 mL (25 º C) |
| BRN | 472689 |
| LogP | 0.820 |
| CAS DataBase Reference | 70-55-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Methylbenzenesulfonamide (70-55-3) |
| EPA Tshuaj Registry System | p-Toluenesulfonamide (70-55-3) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xi, Xn |
| Risk Statements | 36-20/21/22 |
| Cov lus hais txog kev nyab xeeb | 26-36 |
| WGK Germany | 1 |
| RTECS | XT5075000 |
| TSCA | Yog lawm |
| PackingGroup | III |
| HS Code | 29350090 |
| Cov Ntaub Ntawv Muaj Xwm Ceev | 70-55-3(Cov ntaub ntawv muaj phom sij) |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| 4-Methylbenzenesulfonamide | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| p-Toluenesulfonamide Siv thiab Synthesis |
| Lub luag haujlwm thiab lub hom phiaj | P-toluene sulfonamide yog ib yam khoom zoo heev plasticizer siv rau thermoset yas. Nws yog tsim rau siv rau phenolic resin, melamine resin, urea-formaldehyde resins thiab polyamide resins. Kev sib xyaw nrog ib qho me me tuaj yeem txhim kho kev ua haujlwm thiab ua kom lub zog ua kom zoo ib yam, thiab yog li endowing cov khoom nrog gloss zoo. Txawm li cas los xij, P-toluene sulfonamide tsis muaj cov nyhuv softening li cov kua plasticizer, thiab tsis sib xws nrog polyvinyl chloride thiab vinyl chloride copolymer thiab yog ib feem sib xws nrog cellulose acetate, cellulose acetate butyrate thiab cellulose nitrate. p-Toluene sulfonamide muaj toxicity tsawg. Nws tau pom zoo los ntawm US Food and Drug Administration rau kev siv rau hauv cov nplaum ua cov khoom ntim khoom noj. p-Toluene sulfonamide yog luv luv hu ua TSH thiab feem ntau yog siv rau nickel plating. Nws tuaj yeem txhim kho cov txheej txheem txheej los ntawm adsorption ntawm cov electrode kom nws muaj qee qhov kev cuam tshuam ntawm qhov chaw glossing; nws yog feem ntau tsis nruj me ntsis txwv rau qhov ntxiv ntawm brighteners lax; Tsis tas li ntawd nws kuj muaj teeb pom kev zoo rau cov yam ntxwv txheej. Txawm li cas los xij, nws tsuas tuaj yeem muab cov coatings ib nrab ci, thiab lub ntsej muag gloss yog cuam tshuam nrog polishing zoo ntawm matrix ua ntej plating. Tam sim no, cov neeg ua haujlwm ci ci ntawm nickel plating siv feem ntau yog qee yam ntawm cov organic tebchaw. Thiab cov nyiaj siv ntawm cov organic compound no, txawm tias tsawg heev, tab sis nrog cov txiaj ntsig tseem ceeb. Ntxiv nrog rau qhov ci ntsa iab txheej, nws tseem tuaj yeem txiav txim siab ntau yam khoom siv thiab tshuaj lom neeg ntawm cov txheej txheem. Tab sis nws yuav tsum tau paub hais tias, txij li thaum lub ci nickel plating tov tau ntxiv rau cov organic brightener, nws ib txwm ua rau cov nickel plating txheej muaj ib tug txheeb ze loj npaum li cas ntawm cov organic sulfur thiab lwm yam impurities, yog li inevitably enlarging lub sab hauv kev nyuaj siab, yog li nws cov neeg kho tshuab. cov khoom yog ib qho iab qis dua cov pa nickel-phaj, thiab nws yooj yim tawg txheej thaum plating tau txais kev ntxhov siab; nws lub peev xwm antirust kuj tseem phem dua li cov nickel tsaus. Yog li, ib txheej ntawm nickel ci ci tsis tuaj yeem txhim kho corrosion kuj thiab txhua yam khoom ntawm nickel txheej; nws yuav tsum tau tsim ib tug bi-txheej thiab multilayer npib tsib xee los yog chromium los tsim ib tug multilayer ua ke ntawm zoo nkauj tiv thaiv txheej. Thaum toluene sulfonamide yog rhuab mus rau 105 degree, nws yuav decomposed thiab yuav muaj nitrogen tso tawm (gas evolution 130 mL / g); p-toluene sulfonamide foaming agents tuaj yeem muab cov foaming zoo nrog cov khoom me me. Nws kuj muaj lub zog tsim kua muag thiab zoo stability. Li no, nws muaj ntau yam kev siv. Cov ntaub ntawv saum toj no yog kho los ntawm chemicalbook ntawm Dai xiongfeng. |
| Siv | 1. Nws yog siv nyob rau hauv kev tsim cov dyes, hluavtaws resins, xim, tshuaj tua kab mob thiab ntoo ua brightener. 2. Nws yog siv rau kev tsim cov yas yas, tshuaj tua kab mob; Nws tseem tuaj yeem siv rau kev tsim cov khoom siv hluavtaws, xim, thiab cov xim fluorescent. 3. Nws tuaj yeem siv los ua thawj qhov ci ci hauv qhov ci npib tsib xee plating. Nws yog sued rau ci npib tsib xee plating rau multilayer kom tau txais cov xim ci ntsa iab. Nws muaj ntau npaum li cas ntawm 0.2 ~ 0.3 g/L. 4. Nws tuaj yeem siv los ua cov yas yas, kuj siv rau kev sib txuas ntawm cov organic, resins thiab saccharin. |
| Txoj kev tsim khoom | Nws tau txais los ntawm cov tshuaj tiv thaiv ntawm toluenesulfonyl chloride thiab ammonia. Ua ntej, ntxiv ib feem ntawm HN3 dej rau hauv cov tshuaj tiv thaiv lub lauj kaub, nplawm rau ntxiv p-toluenesulfonyl chloride nrog qhov kub thiab txias nce mus rau saum toj 5 0 degree ; Tom qab qhov kub thiab txias tau poob, ntxiv cov ammonia ntxiv thiab muaj cov tshuaj tiv thaiv rau 0.5 h ntawm 85 ~ 90 degree. Nres cov tshuaj tiv thaiv thaum pH nce mus txog 8 mus rau 9. Txias rau 20 degree, lim, thiab ntxuav lub ncuav mog qab zib lim dej kom tau cov khoom nyoos. Tom qab ntawd ntxiv mus los ntawm kev tshuaj dawb los ntawm cov pa roj carbon activated, alkali dissolution, acid nag lossis daus, lim lim, ziab kom tau cov khoom. |
| Chemical Properties | Daim ntawv dawb. Soluble hauv cawv; me ntsis soluble hauv dej.Combustible. |
| Siv | p-Toluenesulfonamide tau siv los npaj cov precursor xav tau rau kev sib txuas ntawm ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. |
| Siv | 4-Tolylsulfonamide yog carbonic anhydrase inhibitor siv cov synthesis ntawm antiglaucoma thiab tshuaj tiv thaiv kab mob. |
| Siv | Siv rau hauv kev tsim cov yas yas, tshuaj tua kab mob, tshuaj tua kab mob, fungicides, ntoo brightener. Tsis tas li ntawd tuaj yeem siv rau hauv kev tsim cov khoom siv hluavtaws, txheej txheej, fluorescent dye, tshuaj, thiab lwm yam. |
| Txhais | ChEBI: Ib qho sulfonamide uas yog benzenesulfonamide bearing pawg methyl ntawm txoj hauj lwm 4. |
| Synthesis Reference (cov) | Phau ntawv Journal of Organic Chemistry, 47, p. 4327 Ib., 1982DOI:10.1021/j00143a031 Synthetic Communications, 20, p. 293 Ib., 1990DOI: 10.1080/00397919008052297 Synthesis, p. 1031 Ib., 1986DOI: 10.1055/s-1986-31862 |
| Kev piav qhia dav dav | p- Toluenesulfonamide tau txais FeCl3-catalyzed direct hloov cov tshuaj tiv thaiv nrog benzylic thiab allylic alcohols.Nws yog ua hauj lwm raws li nucleophile nyob rau hauv tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine qhib cov tshuaj tiv thaiv. |
| Txoj Kev Purification | Crystallize lub amide los ntawm dej kub, ces los ntawm EtOH los yog Et2O / tsiaj ether. [Beilstein 11 H 104, 11 IV 376.] |
| p-Toluenesulfonamide Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw |
| Cov khoom nyoos | Ammonia-->Tosyl chloride-->Carbon-->Terephthaloyl chloride hmoov |
| Cov khoom npaj | 3-ISOPROPENYL-ALPHA,ALPHA-DIMETHYLBENZYL ISOCYANATE-->isoindoline-5-carboxylic acid-->METHYL ISOINDOLINE-5-CARBOXYLATE-->4-bromoisoindoline-->5-BROMOISOINDOLINE-->Ketoconazole-->DIMINAZENE ACETURATE-->Acid Red 92-->NORMEPERIDINE-->Gliclazide-->4-Nitrobenzonitrile-->Isobutylamine-->Probenecid-->Carzenide-->5-Methyl-1H-benzotriazole-->Disperse Red 86-->DICHLORAMINE T-->4-Methylphenylsulfonylurea-->6-amino-10,12-dichloronaphth[2,3-c]acridine-5,8,14(13H)-trione-->Khawb Liab 11 |
Cim npe nrov: p-toluenesulfonamide, Tuam Tshoj p-toluenesulfonamide manufacturers, lwm tus neeg, Hoobkas
Tom ntej: Tosyl Chloride
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