Khoom Taw qhia
| Methyl p-toluenesulfonate Cov ntaub ntawv yooj yim |
| Khoom npe: | Methyl p-toluenesulfonate |
| Synonyms: | 4-methyl-benzenesulfonicacimethylester; Benzenesulfonicacid, 4-methyl-,methylester; Methyl 4-methylbenzenesulfonate; Methyl ester ntawm 4-methylbenzenesulfonic acid; Methyl para-toluenesulfonate; methyl-toluenesulfonate; -Toluolsulfonsaeure methyl ester; p-toluolsulfonsaeuremethylester |
| CAS: | 80-48-8 |
| MF: | C8H10O3S |
| MW: | 186.23 |
| EINECS: | 201-283-5 |
| Khoom Categories: | Tsev Blocks; Chemical Synthesis; Organic Building Blocks; Sulfur Compounds; Organic Building Blocks; Sulfur Compounds; Tosylates; bc0001;80-48-8 |
| Mol File: | 80-48-8.mol |
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| Methyl p-toluenesulfonate tshuaj muaj zog |
| Melting point | 25-28 degree (lit.) |
| Boiling point | 144-145 degree 5 mm Hg (lit.) |
| ceev | 1.234 g / mL ntawm 25 degree (lit.) |
| vapor ceev | 6.45 (vs huab cua) |
| vapor siab | 1 hli Hg (20 degree) |
| Refractive Index | n20/D 1.5172 (lit.) |
| Fp | >230 degree F |
| cia temp. | 2-8 degree |
| solubility | Chloroform (me ntsis), Methanol (me ntsis) |
| daim ntawv | Kua los yog Tsawg Melting Khoom |
| xim | Dawb rau daj |
| Dej Solubility | Insoluble |
| rhiab heev | Moisture Sensitive |
| BRN | 609209 |
| LogP | 1.88 ntawm 25 degree |
| CAS DataBase Reference | 80-48-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenesulfonic acid, 4-methyl-, methyl ester (80-48-8) |
| EPA Tshuaj Registry System | Benzenesulfonic acid, 4-methyl-, methyl ester (80-48-8) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | C, Xn |
| Risk Statements | 22-34-43-40-36/37/38 |
| Cov lus hais txog kev nyab xeeb | 26-36/37/39-45-24 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | XT700000 |
| F | 21 |
| Autoignition Kub | 896 degree F |
| TSCA | Yog lawm |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29051900 |
| Cov Ntaub Ntawv Muaj Xwm Ceev | 80-48-8(Cov ntaub ntawv muaj phom sij) |
| Toxicity | LD50 qhov ncauj hauv Luav: 341 mg / kg |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| Methyl p-tosylate | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| Methyl p-toluenesulfonate Kev siv thiab kev sib xyaw ua ke |
| Chemical Properties | dawb mus rau me ntsis daj tsawg melting khoom. Soluble hauv cawv, ether, benzene, insoluble hauv dej. Hygroscopic. |
| Siv | Methyl p-Toluenesulfonate tuaj yeem siv rau hauv kev tsim cov dyes thiab organic synthesis, thiab tseem yog cov khoom siv raw ntawm methylation. |
| Siv | Methyl p-toluenesulfonate yog siv los ua tus neeg sawv cev methylating hauv cov organic synthesis. Nws ua raws li ib tug catalyst rau alkyd resins. Nws kuj tseem ua haujlwm hauv kev xaiv 1- hloov cov tshuaj tiv thaiv ntawm tetrazole. Tsis tas li ntawd, nws yog siv nyob rau hauv kev npaj ntawm dyes. |
| Kev npaj | Methyl p-toluenesulfonate tau tsim los ntawm cov tshuaj tiv thaiv ntawm p-toluenesulfonyl chloride nrog methanol. Sib tov p-toluenesulfonyl chloride thiab methanol, maj mam ntxiv 25% sodium hydroxide tov, tswj qhov kub hauv qab 25 degree, tsis txhob ntxiv alkali thaum pH yog 9, txuas ntxiv stirring rau 2 teev, thiab tawm hauv hmo ntuj. Cov txheej txheem qis ntawm reactant raug coj mus, txheej sab saud tau muab rho tawm nrog benzene, cov extract tau zoo nrog benzene thiab tom qab ntawd ua ke nrog cov txheej txheem qis, ntxuav nrog dej thiab 5% potassium carbonate tov nyob rau hauv lem, qhuav thiab distilled nyob rau hauv lub siab txo kom tau. Cov khoom tiav ntawm methyl p-toluenesulfonate. |
| Synthesis Reference (cov) | Chemical and Pharmaceutical Bulletin, 29, p. 623, 1981 ibDOI:10.1248/pb.29.623 Synthetic Communications, 15, p. 1057, 1985 ibDOI: 10.1080/00397918508076842 |
| Kev piav qhia dav dav | Methylp-toluenesulfonate yog sulfonate ester tam sim no raws li muaj peev xwm genotoxic impurity nyob rau hauv cov tshuaj yeeb tshuaj. Kinetics ntawm cov tshuaj tiv thaiv methylp-toluenesulfonate nrogN,N-dimethylaniline tau tshawb xyuas. Nws koom nrog kev xaiv 1- hloov cov tshuaj tiv thaiv ntawm tetrazole. |
| Hazard | Toxic los ntawm kev noj thiab nqus pa, muaj zog rau daim tawv nqaij thiab qhov muag. |
| Kev ruaj ntseg Profile | Tshuaj lom los ntawm kev noj tshuaj thiab subcutaneous txoj kev. Qhov muag thiab tawv tawv heev irritant. Ib tug vesicant thiab daim tawv nqaij sensitizer. Cov lus nug carcinogen nrog cov ntaub ntawv sim tumorigenic. Thaum rhuab mus rau decomposition nws emits cov pa phem ntawm SOx. |
| Txoj Kev Purification | Cov ester yog purified los ntawm distillation hauv vacuo thiab tuaj yeem crystallized los ntawm tsiaj ether lossis Et2O / tsiaj ether ntawm qhov kub thiab txias. Nws yog ib qho muaj zog methylating tus neeg sawv cev, yog TOXIC thiab yog cov tawv nqaij khaus, yog li nws yog qhov zoo dua los ntxuav nws los ntawm kev rov ua dua. [IR: Schreiber Anal Chem 21 1168 1949, Buehler et al. J Org Chem 2 167 1937, Roos et al. Org Synth Coll Vol I 145 1948, Beilstein 11 IV 247.] |
| Methyl p-toluenesulfonate Kev npaj cov khoom thiab cov ntaub ntawv raw |
| Cov khoom nyoos | Tosyl chloride-->4-methylbenzenediazonium tetrafluoroborate-->Tetrabutylammonium 4-toluenesulfonate-->[Hydroxy(tosyloxy)iodo]benzene-->4-Toluenesulfonyl bromide-->2,2,2-TRIFLUOROETHYL METHYL ETHER-->DIMETHYLZINC-->Tom ntej: Trimethyl Orthoacetate |
| Cov khoom npaj | 1,3,3-Trimethyl-2-methyleneindoline-->5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE-->2,5-diphenylthiazole-->3,5-Bis(2-cyanoprop-2-yl)toluene-->1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene-->2-NONYNE-->METHYL FLUORIDE-->METHYL 3,5-DIMETHYLBENZOATE-->2-CHLORO-1-METHYLPYRIDINIUM P-TOLUENESULFONATE-->ETHYL METHYL ETHER-->3,6-diamino-2,7,10-trimethylacridinium chloride-->Basic Orange 5 |
Cim npe nrov: Tuam Tshoj methyl p-toluenesulfonate manufacturers, lwm tus neeg, Hoobkas
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