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N, N-Disopropylethylamine

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N, N-Disopropylethylamine Cov ntaub ntawv yooj yim

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Khoom npe:	N, N-Disopropylethylamine
Synonyms:	3-METHYL-1-BUTINE-3-OL; N, N-DIISOPROPYLETHYLAMINE (Atofina EDIPA; N N-DIISOPROPYLETHYLAMINE (Atofina ED&;N N-DIISOPROPYLETHYLAMINE REAGENTPLUS) ~ MINESOPROPYLETHYLAMINE 2 M; N, N-DIISOPROPYLETHYLAMINE, BIOTECH GRADE SOLVENT, 99.5% N-ETHYLDIISOPROPYLAMINE, 4X25 ML VIALS; N, N-Di-#niso-propylethylamine
CAS:	7087-68-5
MF:	C8H19N
MW:	129.24
EINECS:	230-392-0
Khoom Categories:	ACS thiab Reagent Grade Solvents; Combinatorial Chemistry; Lwm Cov Reagents; Synthetic Organic Chemistry; Chemistry; Kev Tsim Kho; Kev Tshawb Nrhiav Cov Amines rau Thawj Amines (rau Kev Tshawb Nrhiav Dawb Amine ntawm Cov Resins); Amber iav fwj; Cov Tshuaj Tseem Ceeb; Inorganic Ntxiv ntsev; ReagentPlus; ReagentPlus Solvent Grade Products; Research Essentials; Solutions and Reagents; Solvent bottles; solvent by Application; solvent ntim Options; Solvents; bc0001;7087-68-5
Mol File:	7087-68-5.mol

N, N-Disopropylethylamine Chemical Properties

Melting point	<-50 °C (lit.)
Boiling point	127 degree (lit.)
ceev	0.742 g/mL ntawm 25 degree (lit.)
vapor siab	31 mmHg (37.7 degree)
Refractive Index	n20/D 1.457
Fp	6 degree
cia temp.	Khaws hauv qab +30 degree .
solubility	miscible
daim ntawv	Ua kua
pka ua	1 0.98 ± 0.28 (Tshaj tawm)
Specific Gravity	0.755 (20/4 degree)
xim	APHA:<20
PH	12.3 (H2O, 20 degree) (raws li emulsion)
tawg txwv	0.7-6.3%(V)
Dej Solubility	miscible
BRN	605301
Kev ruaj ntseg:	Volatile
InChIKey	JGFZNNIVVJXRND-UHFFFAOYSA-N
LogP	-1.8 ntawm 22.5 degree
CAS DataBase Reference	7087-68-5(CAS DataBase Reference)
NIST Chemistry Reference	(i-C3H7)2(C2H5)N(7087-68-5)
EPA Tshuaj Registry System	2-Propanamine, N-ethyl-N-(1-methylethyl)- (7087-68-5)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	C,F,T
Risk Statements	11-22-34-52/53-20/21/22-10-41-37/38-20/22-36/37/38-61
Cov lus hais txog kev nyab xeeb	26-36/37/39-45-61-16-27-60-23-9-53
RIDADR	UN 2734 8/PG 2
WGK Germany	2
F	9-34
Autoignition Kub	240 degree
Ceeb toom	Highly Flammable / Corrosive / Harmful
TSCA	Yog lawm
HazardClass	3
PackingGroup	II
HS Code	29211980
Toxicity	LD50 hais lus hauv Luav: > 200 - 500 mg/kg

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
Huenig lub hauv paus	Lus Askiv
SigmaAldrich	Lus Askiv
ACROS	Lus Askiv
ALFA	Lus Askiv

N, N-Disopropylethylamine Siv thiab Synthesis

Kev piav qhia	N, N-Disopropylethylamine tseem hu ua Hunig lub hauv paus thiab abbreviated li DIPEA los yog DIEA, Nws yog ib tug sterically hindered amine thiab ib tug organic compound. Cov kua tsis muaj xim muaj npe hu ua Hung lub hauv paus tom qab Siegfried Hunig, German chemist. Nws yog noteworthy tias lub compound yog ua lag luam. Hauv cov organic chemistry, N, N-Disopropylethylamine yog siv los ua lub hauv paus. Txij li thaum lub chaw nitrogen yog cais los ntawm ib pawg ethyl thiab ob pawg isopropyl, Nws tuaj yeem khi rau protons. Cov compound yog, yog li ntawd, lub hauv paus zoo ib yam li 2,2,6,6-tetramethylpiperidine, tab sis tsis zoo nucleophile, ib qho kev sib xyaw ntawm cov khoom uas ua rau nws muaj txiaj ntsig zoo li cov organic reagent.
Stability thiab Reactivity	DIPEA nthuav tawm cov tshuaj tiv thaiv hnyav nrog rau cov nplaim taws nrog nitrates, oxidizing cov neeg ua haujlwm, thiab peroxides. Nws tuaj yeem hnov mob heev exothermically thiab muaj peev xwm nchuav nrog halogens thiab muaj zog acids. Nyob rau hauv ib puag ncig alkaline, lub compound yuav ua rau muaj kev kub ntxhov. Tsis tas li ntawd, qhov sib xyaw ua ke tuaj yeem tsim cov khoom lom xws li n-nitrosamines thaum ua ke nrog nitrous acid nrog rau cov pa oxygen, nitrosating agents, thiab nitrates. Raws li ib txwm muaj (kub thiab siab), DIPEA ruaj khov heev. Txawm li cas los xij, nws yog soluble hauv feem ntau cov kuab tshuaj organic.
Daim ntawv thov	N, N-Disopropylethylamine yog siv los ua lub hauv paus hauv palladium (0) catalysed alkoxycarbonylation ntawm ob qho tib si allyl acetates thiab phosphates. Nws yog siv los ua ib qho nruab nrab ntawm cov tsim phosphoric acid. Qhov tseem ceeb, alkyl ester tsis tuaj yeem tsim tsis muaj DIPEA. Thaum ua ke nrog boryl triflates, N, N-Disopropylethylamine yog siv nyob rau hauv enolate synthesis ntawm ketones rau daim ntawv thov nyob rau hauv cov kev taw qhia cross-adol tshuaj. DIPEA yog siv los ua proton scavenger hauv organic synthesis. Txij li thaum lub compound yog sterically hindered amine, nws tsis muaj quaternization; Yog li ntawd, ua rau nws yog ib qho kev xaiv zoo tshaj plaws ntawm lub hauv paus rau kev siv nrog cov tshuaj reactive alkylating heev. DIPEA yog tshwj xeeb yog pab tau raws li lub hauv paus nyob rau hauv kev tiv thaiv ntawm cawv raws li hloov ethers nyob rau hauv lub teb ntawm kev tiv thaiv pab pawg neeg chemistry. Nyob rau hauv lub synthesis ntawm peptides, lub compound kuj yog siv nyob rau hauv lub coupling ntawm amino acids. Qhov xwm txheej tsis zoo thiab qhov pib ntawm DIPEA thaum lub sij hawm sib txuas cov tshuaj tiv thaiv cuam tshuam rau qib ntawm racemization.
Chemical Properties	Diisopropylethylamine (DIPEA) yog ib qho ntshiab, tsis muaj xim rau lub teeb daj, insoluble hauv dej thiab yooj yim soluble hauv acetone thiab lwm cov kuab tshuaj organic.
Siv	N, N-Disopropylethylamine yog siv los ua lub hauv paus hauv cov tshuaj tiv thaiv organic. Siv nyob rau hauv kev npaj ntawm (-) Gambierol ib tug marine polycyclic ether toxin. Nws kuj yog siv rau hauv kev sib txuas ntawm cov muaj zog inhibitors ntawm tib neeg lub hlwb memapsin, ib qho tseem ceeb effector nyob rau hauv kev loj hlob ntawm Alzheimer's kab mob.
Daim ntawv thov	N, N-Disopropylethylamine yog ib qho tseem ceeb ntawm cov tshuaj tua kab thiab tshuaj nruab nrab, uas tuaj yeem siv los ua cov tshuaj loog thiab tshuaj tua kab mob, thiab tseem tuaj yeem siv los ua sterically hindered amine los koom nrog ntau yam tshuaj tiv thaiv catalytic.
Kev npaj	N, N-Disopropylethylamine yog siv los ua non-nucleophilic puag hauv organic synthesis. Nws yog npaj los ntawm alkylation ntawm diisopropylamine nrog diethyl sulphate. DIPEA tuaj yeem ua kom huv los ntawm distillation los ntawm potassium hydroxide yog tias tsim nyog.
Txhais	ChEBI: N, N-Disopropylethylamine (DIPEA) yog ib qho tertiary amino compound.
Kev piav qhia dav dav	N-Ethyldiisopropylamine (EDIA) reacts nrog monoactivated Michael txais yuav them taus symmetrical sulfones.
Flammability thiab Explosibility	Cov nplaim taws heev
Txoj Kev Purification	Distil cov amine los ntawm ninhydrin, ces los ntawm KOH [Dryland & Sheppard, J Chem Soc, Faraday Trans 1 125 1986]. Nws yog lub hauv paus muaj zog thiab yuav tsum tau khaws cia hauv qhov tsis muaj carbon dioxide. [Hünig & Kiessel Chem Ber 91 380, 387 1958, Wotiz et al. J Org Chem 24 1202 1959, Beilstein 4 IV 551.]

N, N-Disopropylethylamine Npaj Cov Khoom Siv thiab Cov Khoom Raw

Cov khoom npaj

(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-DIMETHYLAMINE-->3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER-->N-Boc-5,6,7,8-tetrahydro-3-methoxy-[1,2,4]triazolo[4,3-A]pyrazine ,98%-->2-Ethylpiperazine-->3-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE-->1-Boc-Azetidine-3-yl-methanol-->BAPTA, TETRASODIUM SALT-->BAPTA-->3-Azetidinecarboxylic acid-->2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBALDEHYDE-->4,5-Diaminopyrimidine-->3-(N-Boc-aminomethyl)azetidine-->1-Boc-3-(Aminomethyl)azetidine-->2-(PIPERAZIN-1-YL)-ACETIC ACID N-(2-PHENYLETHYL)-AMIDE-->1-Boc-3-Cyanoazetidine-->TERT-BUTYL N-(BENZYLOXY)CARBAMATE-->METHYL 2-((PIPERIDIN-4-YL)METHYL)BENZOATE-->2-((1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)METHYL)BENZOIC ACID-->3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE-->(R)-4-Boc-Piperazine-3-carboxylic acid-->5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one-->6-CHLORO-5-NITROPYRIMIDIN-4-AMINE-->N-(4-FORMYL-PYRIDIN-3-YL)-2,2-DIMETHYL-PROPIONAMIDE-->3-((1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)METHYL)BENZOIC ACID-->4-((1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)METHYL)BENZOIC ACID-->METHYL 4-((PIPERIDIN-4-YL)METHYL)BENZOATE-->METHYL 3-((PIPERIDIN-4-YL)METHYL)BENZOATE-->METHYL 5-NITRO-2-FUROATE-->5-Amino-4,6-dichloropyrimidine-->4,6-Dichloro-5-nitropyrimidine-->4-(3-BROMOPHENYL)MORPHOLINE-->Faropenem sodium hemipentahydrate-->5-AMINO-6-CHLORO-PYRIMIDIN-4-OL-->4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE-->4-CHLORO-6-HYDRAZINO-PYRIMIDIN-5-YLAMINE-->4-ETHYNYLANILINE-->3-Bromo-2-methoxy-propene-->PIPERAZINE-1, 4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER

Cim npe nrov: n-diisopropylethylamine, Tuam Tshoj n-diisopropylethylamine manufacturers, lwm tus neeg, Hoobkas

Tug: 2-Aminoethyldiisopropylamine

Tom ntej: 2,2, 2-Trifluoroethylamine Hydrochloride

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