Khoom Taw qhia
| Benzophenone Cov ntaub ntawv yooj yim |
| Cov lus piav qhia Cov Khoom Siv Tshuaj Siv Cov Khoom Siv Cov Khoom Siv Tshuaj Toxicity Production method |
| Khoom npe: | Benzophenone |
| Synonyms: | Dipheny ketone; Mettler toledotm calibration tshuaj kuv 18870, benzophenone; BENZOPHENONE FLAKE; UV500; BENZOPHENONE, REAGENT; Benzophenone, BP; BENZOPHENONE REAGENTPLUS (TM) 99%; BENZOPHENONE CRYSTAL |
| CAS: | 119-61-9 |
| MF: | C13H10O |
| MW: | 182.22 |
| EINECS: | 204-337-6 |
| Khoom Categories: | Flavor & Fragrance Intermediates; Fluorescent Labels thiab Indicators; Analytical Chemistry; Environmental Endocrine Disruptors; Bioactive Me Molecules; Cell Biology; Pharmaceutical Intermediates; Additives for Plastic; Organics; Essential Chemicals; Inorganic Salts; Reagent Plus; Reagent Ntxiv thiab Reagents , thiab lwm yam. (Environmental Endocrine Disruptors); Cov Khoom Siv Ua Haujlwm; Photopolymerization Initiators; Fluorescent Labels & Indicators; Aromatics; Intermediates; organic chemical; Tsev Blocks; C13 txog C14; Carbonyl Compounds; Chemical Synthesis; Ketones; Organic Building Blocks 2}};bc0001 |
| Mol File: | 119-61-9.mol |
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| Benzophenone Chemical Properties |
| Melting point | 47-51 degree (lit.) |
| Boiling point | 305 degree (lit.) |
| ceev | 1.11 |
| vapor ceev | 4.21 (vs huab cua) |
| vapor siab | 1 hli Hg (108 degree) |
| Refractive Index | 1.5893 |
| FEMA | 2134|Ib benzophenone |
| Fp | >230 degree F |
| cia temp. | Khaws hauv qab +30 degree . |
| solubility | ethanol: soluble 100mg / mL, ntshiab, tsis muaj xim (80% ethanol) |
| daim ntawv | Crystalline hmoov los yog Flakes |
| xim | Dawb mus rau dawb |
| tsw | Yam ntxwv. |
| Hom tshuaj tsw qab | balsam |
| Dej Solubility | insoluble (<0.1 g/100 mL at 25 ºC) |
| Merck | 14,1098 |
| JECFA Number | 831 |
| BRN | 1238185 |
| Dielectric tsis tu ncua | 13. 0(20 degree) |
| Kev ruaj ntseg: | ruaj khov. Incompatible nrog muaj zog oxidizing agents, muaj zog txo cov neeg ua hauj. Hluav taws kub. |
| InChIKey | RWCCWEUUXYIKHB-UHFFFAOYSA-N |
| LogP | 3.18 ntawm 25 degree |
| CAS DataBase Reference | 119-61-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzophenone (119-61-9) |
| IARC | 2B (Vol. 101) 2013 |
| EPA Tshuaj Registry System | Benzophenone (119-61-9) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xi, N, Xn, F |
| Risk Statements | 36/37/38-52/53-50/53-67-65-62-51/53-48/20-11-40 |
| Cov lus hais txog kev nyab xeeb | 26-61-37/39-29-60-36-62-36/37-33-16-9 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | PAB 995000 |
| F | 10 |
| TSCA | Yog lawm |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29143900 |
| Cov Ntaub Ntawv Muaj Xwm Ceev | 119-61-9(Cov ntaub ntawv muaj phom sij) |
| Toxicity | LD50 qhov ncauj hauv luav: > 10000 mg/kg LD50 dermal luav 3535 mg/kg |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| Benzophenone | Lus Askiv |
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| Benzophenone Siv thiab Synthesis |
| tsw | Heev faint, powdery-rosy, geranium-zoo li tsw nrog ib tug me ntsis metallic daim ntawv. |
| piav qhia | Diphenyl ketone [119-61-9], benzophenone, C6H5COC6H5, C13H10O, Mr 182.22. Daim ntawv ruaj khov ntawm diphenyl ketone muaj cov xim tsis muaj xim rhombic prismatic crystals. Ntau cov ntaub ntawv tsis ruaj khov nrog cov ntsiab lus melting qis kuj muaj. Diphenyl ketone yog insoluble hauv dej thiab yooj yim soluble hauv cov kuab tshuaj organic. Diphenyl ketone thiab hloov diphenyl ketones tshwj xeeb yog siv los ua photoinitiators rau UV-curable printing inks thiab coatings. Diphenyl ketone kuj tseem siv los ua ib qho nruab nrab rau cov tshuaj thiab tshuaj ua liaj ua teb. Nws yog ua hauj lwm nyob rau hauv lub perfume kev lag luam raws li ib tug fixative thiab raws li ib tug fragrance nrog ib tug flowery daim ntawv. |
| Chemical Properties | ci dawb prismatic crystals nrog ib tug qab zib saj, tsw zoo li ib tug sawv, melting point yog 47-49 degree, boiling point yog 306 degree, insoluble nyob rau hauv dej, soluble nyob rau hauv cawv, ether thiab chloroform. |
| daim ntawv thov | Sunscreen tshuaj pleev ib ce yog cov khoom kub tshiab ntawm cov tshuaj pleev ib ce, yuav luag tag nrho cov tshuaj pleev thaiv hnub muaj benzophenone compound ntawm lub khw tam sim no. Benzophenone compounds uas tiv thaiv daim tawv nqaij los ntawm kev puas tsuaj, feem ntau yog siv los tsim cov khoom siab. Nyob rau hauv xyoo tas los no, kev siv tshuaj pleev ib ce ntawm benzophenone txuas ntxiv mus. Cov kev tshawb fawb tsis ntev los no qhia tias fluorescence kuj yog qhov teeb meem ultraviolet lub teeb, yog li benzophenone nthuav dav ntau yam kev siv hauv cov tshuaj pleev ib ce, nws tau txuas ntxiv mus rau cov plaub hau txias, tshuaj pleev thiab pleev pleev. Tsis tas li ntawd, cov naj hoom fixative tus neeg sawv cev kuj tuaj yeem muab cov txuj lom qab zib, yog siv ntau yam tshuaj tsw qab thiab xab npum tsw. Lub tuam txhab Banana Boat tau tsim lub tshuab UVA ultraviolet-absorbing technology hu ua AvoTriplex, uas yog benzophenone-based, ntxiv cov stabilizer los tiv thaiv cov benzophenone los ntawm kev tawg hauv lub hnub. Enhancer kuj tseem ntxiv rau hauv cov mis, thiab stabilizer tuaj yeem ua haujlwm sib koom ua ke, txhawm rau txhim kho benzophenone tshuaj pleev thaiv hnub muaj peev xwm. |
| Siv |
Benzophenone Feem ntau siv rau kev npaj ntawm vanilla, butter thiab lwm yam tsw, Nws tuaj yeem siv los ua tus neeg sawv cev fixative. Nws tsis muaj zog qab zib bay nplooj muaj ntxhiab tsw, tuaj yeem siv dav hauv qib qis, xws li roses, bay nplooj, qab zib curd, txaj muag paj, lily ntawm lub hav, sunflower, orchid, hawthorn paj, xyab thiab Wei Oriental tsw thiab lwm yam flavors. . Nws kuj yog siv los ua cov tshuaj antioxidant hauv xab npum, thiab qee zaus siv rau almonds, berries, txiv hmab txiv ntoo, butter, txiv ntseej, txiv duaj, taum vanilla thiab lwm yam khoom noj qab haus huv hauv kab. Siv rau photosensitive resins, coatings thiab adhesives. Benzophenone yog ib qho nruab nrab ntawm UV absorbers, organic pigments, tshuaj, naj hoom, tshuaj tua kab. Nws yog siv rau kev tsim cov bicyclic Piperidine Benztropine hydrobromide, diphenhydramine hydrochloride hauv kev lag luam kws tshuaj. Cov khoom nws tus kheej yog ib tug styrene polymerization inhibitor thiab ib tug perfume fixative. Muab qab zib rau cov tsw qab, nws yog siv ntau yam tshuaj tsw qab thiab xab npum tsw. Nws yog feem ntau siv hauv xab npum tsw, siv nyob rau hauv ultraviolet absorbers, pigments, tshuaj thiab reagents ntau lawm, thiab kuj yog kub tsis kub ceev curing tus neeg saib xyuas rau fluorine roj hmab. Nws ua haujlwm rau cov neeg tsim khoom kom ntim cov khoom hauv cov iav ntshiab lossis yas. Benzophenone yog dav siv los ua tus thawj coj yees duab hauv UV-kho daim ntaub ntawv xws li inks, imaging thiab clear coatings hauv kev lag luam luam ntawv. Nws ua raws li UV blocker los tiv thaiv cov duab-degradation ntawm cov ntim khoom polymers lossis nws cov ntsiab lus. Nws yog lub teeb pib rau UV khoom, tshuaj intermediates, fragrances, lub teeb stabilizers thiab lwm yam. Nws yog lub teeb xim, tshuaj, naj hoom, tshuaj tua kab intermediates, nws kuj siv tau rau UV-kho resins, inks thiab coatings pib. |
| qhov taw qhia | Benzophenone yog dav siv nyob rau hauv lub synthesis sim ua ib qho kev qhia, nws yuav siv tau raws li ib tug qhia thaum tuav toluene, benzene, THF, acetonitrile ect.; yog tias muaj cov xiav zoo nkauj tom qab ntxiv, nws tuaj yeem distillation thiab siv tau, nws yog qhov zoo tshaj plaws khaws cia hauv sodium, tab sis vim li cas ntawm kev tsim xiav tseem yog ib qho puzzle. Ntawm no yog vim li cas los ntawm ib tug txawv teb chaws phau ntawv hais txog cov tshuaj tiv thaiv mechanism: ib tug radical anion generated los ntawm ib tug hu ua carbonyl radical, benzophenone ua raws li qhov taw qhia yog tias benzophenone oxygen atoms nyob rau hauv sodium capture electrons los tsim tsaus xiav carbonyl radical; radicals foundations ntawm cov hluav taws xob nam yog ruaj khov, feem ntau yog siv los qhia 'anaerobic tej yam kev mob', Dav siv. Tom qab qhov sib ntxiv ntawm benzophenone, ntau xiav ntawm cov tshuaj, qhia tias tsawg oxygen hauv cov tshuaj, indirectly qhia cov dej me me. Txawm li cas los xij, txawm hais tias qhov kev daws teeb meem tig xiav, muaj feem cuam tshuam nrog cov nyiaj ntxiv ntawm benzophenone thiab cov kuab tshuaj ua haujlwm, THF (300ml) muaj cov dej ntau, thiab xav tau ntau tshaj li 6 teev kom reflux, thiab tau kawg, nws muaj feem xyuam rau cov nqi ntawm Kev ua cov kuab tshuaj, qhov ntev dua, toluene, benzene thiab lwm cov qauv uas muaj cov dej tsis txaus xav tau lub sijhawm rov qab los, nws yog qhov zoo tshaj rau ntxiv cov desiccants rau pretreat, xws li: potassium carbonate, sodium sulfate, sodium hydroxide, thiab lwm yam. lub sijhawm ua haujlwm yuav luv. |
| Toxicity | GRAS (FEMA). LD502897mg/kg (Ntaus, qhov ncauj). |
| Txoj kev tsim khoom | Muaj ntau txoj hauv kev los ua ke benzophenone. Ib txoj hauv kev suav nrog condensing benzyl chloride thiab benzene, tom qab ntawd oxidation nrog nitric acid. Lwm txoj kev suav nrog condensing benzene thiab carbon tetrachloride, ua raws li hydrolysis. Hauv kev tsim khoom, benzophenone feem ntau yog tsim los siv txhuas chloride ua ib qho catalyst, nrog benzene reacting nrog benzoyl chloride. Txoj kev zaum kawg suav nrog condensing benzene thiab benzoyl chloride nyob rau hauv lub xub ntiag ntawm txhuas chloride, ua raws li crystallization los ntawm ethanol. |
| Kev piav qhia | Benzophenone yog combustible, dawb, crystalline khoom nrog ib tug Rose zoo li tsw. Molecular hnyav=182.23; Lub ntiajteb txawj nqus tshwj xeeb (H2O: 1)=1 085 ntawm 50 degree ; Boiling point=305 degree ; Txias / Melting point=48.5 degree ; Latent cua sov ntawm vaporization{11}} 93 3 105 J/kg; Kub ntawm combustion=-358 3 105 J/kg. Kev txheeb xyuas qhov phom sij (raws li NFPA-704 M Rating System): Kev Noj Qab Haus Huv 1, Flammability 1, Reactivity 0. Insoluble hauv dej. |
| Chemical Properties | Benzophenone yog combustible, dawb, crystalline khoom nrog ib tug rose zoo li tsw. Soluble nyob rau hauv ethanol, ether, chloroform thiab lwm yam organic solvents thiab monomers, insoluble nyob rau hauv dej. Nws yog ib tug dawb radical photoinitiator, feem ntau yog siv nyob rau hauv dawb radical UV curing systems, xws li coatings, inks, adhesives, thiab lwm yam. Nws tuaj yeem npaj tau ntau txoj hauv kev, piv txwv li, los ntawm Friedel-Crafts cov tshuaj tiv thaiv ntawm benzene thiab benzoyl chloride nrog txhuas chloride. , los yog ntawm benzene thiab carbon tetrachloride, thiab oxidation ntawm diphenylmethane. |
| Qhov tshwm sim | Benzophenone tau pom nyob rau hauv ntau yam txiv hmab txiv ntoo, xws li Vitis vinifera L., dub tshuaj yej, cherimoya (Annona cherimola), roob papaya (Carica pubescens), thiab soursop (Annona muricata L.). |
| Siv | Benzophenone yog siv los ua ib qho khoom siv nruab nrab rau kev tsim tshuaj thiab tshuaj ua liaj ua teb. Nws kuj yog siv los ua ib qho photoinitiator hauv UV-curable printing inks, ua cov tshuaj tsw qab hauv cov tshuaj tsw qab, ua ib qho tsw hauv cov khoom noj. Benzophenone tuaj yeem muab ntxiv ua tus neeg saib xyuas UV-absorbing rau plastics, lacquers, thiab coatings ntawm qhov ntau ntawm 2-8%. |
| Txhais | ChEBI: Benzophenone yog cov tswv cuab yooj yim tshaj plaws hauv chav kawm ntawm benzophenones, ua formaldehyde uas ob qho tib si hydrogens hloov los ntawm phenyl pawg. Nws muaj lub luag haujlwm ua tus neeg sawv cev photosensitizing thiab cov nroj tsuag metabolite. |
| Txoj kev tsim khoom | Benzophenone yog kev lag luam tsim los ntawm atmospheric oxidation ntawm diphenylmethane siv lub catalyst ntawm tooj liab naphthenate. Xwb, nws tuaj yeem tsim los ntawm Friedel-Crafts acylation ntawm benzene siv benzoyl chloride los yog phosgene nyob rau hauv muaj cov txhuas chloride. |
| Synthesis Reference (cov) | Tetrahedron Letters, 36, p. 2285, 1995 ibDOI: 10.1016/0040-4039(95)00191-E Chemical and Pharmaceutical Bulletin, 34, p. 3595, 1986 ibDOI:10.1248/cpb.34.3595 |
| Kev piav qhia dav dav | Benzophenone(119-61-9) tshwm li cov khoom dawb nrog cov ntxhiab tsw tsw. Tej zaum yuav ntab los yog tog hauv dej. Nws yog ib qho siv dav hauv tsev thaiv hauv cov organic chemistry, ua tus niam txiv diarylketone. |
| Cua & Dej Reactions | Insoluble hauv dej. |
| Reactivity Profile | Ketones, xws li Benzophenone, yog reactive nrog ntau cov kua qaub thiab cov hauv paus liberating cov cua sov thiab cov pa hluav taws xob (xws li, H2). Cov cua sov yuav txaus los pib hluav taws nyob rau hauv qhov tsis muaj kev cuam tshuam ntawm ketone. Ketones hnov mob nrog txo cov neeg ua haujlwm xws li hydrides, alkali hlau, thiab nitrides los tsim cov pa roj (H2) thiab cua sov. Ketones tsis sib haum nrog isocyanates, aldehydes, cyanides, peroxides, thiab anhydrides. Lawv hnov mob hnyav nrog aldehydes, HNO3, HNO3 + H2O2, thiab HClO4. Benzophenone tuaj yeem ua rau cov ntaub ntawv oxidizing. |
| Health Hazard | Kev noj zaub mov ua rau mob plab hnyuv. Kev sib cuag ua rau qhov muag khaus thiab, yog tias ntev, khaus ntawm daim tawv nqaij. |
| Hluav Taws Xob | Flash point cov ntaub ntawv rau Benzophenone tsis muaj, tab sis Benzophenone yog tej zaum combustible. |
| Tiv tauj cov allergens | Unsubstituted benzophenone feem ntau yog siv rau hauv kev siv tshuaj lom neeg. Nws ua raws li tus cim rau photoallergy rau ketoprofen. |
| Kev ruaj ntseg Profile | Muaj tshuaj lom los ntawm kev noj tshuaj thiab cov kab mob hauv lub cev. Combustible thaum rhuab.Incompatible nrog oxidizers. Thaum rhuab todecomposition nws emits acrid thiab irritating fumes. |
| Ntxim yuav nphav raug | Benzophenone yog siv nyob rau hauv UV kho ntawm inks thiab coatings; raws li qhov nruab nrab; raws li ib tug tsw fixative nyob rau hauv fragrances, flavoring, soaps; hauv kev tsim tshuaj thiab tshuaj tua kab; nyob rau hauv cov organic syntheses. |
| Kev pab thawj zaug | Yog hais tias cov tshuaj no nkag mus rau hauv lub qhov muag, tshem tawm ib qho kev sib cuag lo ntsiab muag ib zaug thiab irrigate tam sim ntawd rau tsawg kawg yog 15 feeb, qee zaus nqa lub hau sab sauv thiab qis dua. Nrhiav kev kho mob tam sim ntawd. Yog tias cov tshuaj no cuam tshuam rau ntawm daim tawv nqaij, tshem cov khaub ncaws tsis huv thiab ntxuav tam sim nrog xab npum thiab dej. Nrhiav kev kho mob tam sim ntawd. Yog tias cov tshuaj no tau nqus tau lawm, tshem tawm ntawm qhov raug, pib ua pa cawm siav (siv kev ceev faj thoob ntiaj teb, suav nrog daim npog qhov ncauj resuscitation) yog ua tsis taus pa thiab CPR yog tias lub plawv nres. Hloov tam sim ntawd mus rau qhov chaw kho mob. Thaum cov tshuaj no tau nqos lawm, yaug qhov ncauj thiab mus kho mob. |
| Carcinogenicity | Kev tshawb fawb txog kev mob qog noj ntshav hauv lub neej nyob rau hauv nas thiab luav tsis pom muaj qog ntau tshaj hauv cov tsiaj kho. Poj niam Swiss nas thiab New Zealand Dawb luav ntawm ob leeg poj niam raug kho dermally nrog {{{0}}, 5, 25, lossis 50% ntawm benzophenone (0.02 mL) ob zaug hauv ib lub lis piam rau 120 lossis 180 lub lis piam. Kev ntsuam xyuas txhua lub limtiam ntawm luav tsis tau qhia txog kev txo qis hauv kev muaj sia nyob lossis pom cov qog. Cov nas uas kho nrog benzophenone tsis pom muaj ntau tshaj ntawm cov tsiaj qog nqaij hlav lossis tag nrho cov qog piv rau cov tsiaj tswj tsis tau kho. Txawm hais tias peb cov qog nqaij hlav tau pom nyob rau hauv cov nas kho benzophenone (ib kis ntawm squamous cell carcinoma thiab ob kis ntawm squamous cell papilloma), kuj tseem muaj peb cov qog (ib qho mob qog noj ntshav thiab ntiv taw papillomas) pom hauv cov tsiaj tswj. |
| Metabolism | Benzophenone lub ntsiab metabolic txoj kev nyob rau hauv luav yog los ntawm kev txo rau benzhydrol, uas yog excreted conjugated nrog glucuronic acid (Williams, 1959). |
| Solubility hauv cov organic | Insoluble hauv dej thiab glycerin, me ntsis soluble hauv Propylene glycol, 6% soluble hauv cawv, soluble inmost perfume roj. |
| khaws cia | Xim Code-Green: Kev khaws cia dav dav tuaj yeem siv tau.Sau hauv qhov chaw txias, qhov cua zoo kom deb ntawm qhov chaw taws teeb thiab cov ntaub ntawv tsis sib xws. |
| Kev xa khoom | UN1224 Ketones, kua, nos, Hazard Class: 3; Cov ntawv lo: 3-Flammable kua, Technical Name Yuav tsum tau. UN3077 Environmentally hazardous substances, solid, nos, Hazard class: 9; Cov ntawv lo: 9-Lwm yam khoom siv phom sij, Kev Siv Lub Npe Yuav Tsum Tau. |
| Txoj Kev Purification | Crystallize nws los ntawm MeOH, EtOH, cyclohexane, * benzene los yog tsiaj ether, ces qhuav nyob rau hauv ib tug tam sim no ntawm huab cua sov thiab cia nws tshaj BaO los yog P2O5. Nws kuj yog purified los ntawm cheeb tsam melting thiab sublimation [Itoh J Phys Chem 89 3949 1985, Naguib li al. J Am Chem Soc 108 128 1986, Gorman & Rodgers J Am Chem Soc 108 5074 1986, Ohamoto & Teranishi J Am Chem Soc 108 6378 1986, Naguib et al. J Phys Chem 91 3033 1987]. [Beilstein 7 III 2048, 7 IV 1357.] |
| Kev tsis sib haum xeeb | Oxidizing cov ntaub ntawv, xws li dichromates thiab permanganates. |
| Benzophenone Npaj Cov Khoom Siv Thiab Cov Khoom Raw |
| Cov khoom nyoos | Benzene-->Aluminum chloride-->Carbon tetrachloride-->Benzoyl chloride-->PHOSGENE-->Aluminium chloride hexahydrate |
| Cov khoom npaj | 3-Azetidinecarboxylic acid-->4-Methoxytriphenylmethyl chloride-->1-N-Boc-3-hydroxyazetidine-->1-AMINOCYCLOPROPANECARBONITRILE-->2-AMINOPENT-4-YNENITRILE-->Benzophenone hydrazone-->Benzophenone imine-->3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene-->Fluotrimazol-->Benzhydrol-->2-Amino-5-nitrobenzophenone-->Basic Blue 11-->Nizofenone-->4-Benzoyl Acetanilide-->Clonazepam-->Difenidol hydrochloride-->BENZP-DINITRIDE-THIO-KETONE-->TAMPRAMINE-->N-Phenylbenzohydroxamic acid-->Nordazepam-->3-Bromobenzophenone-->Toremifene-->alpha-[1-(aminomethyl)propyl]benzhydryl alcohol-->3,3'-DINITROBENZOPHENONE-->2-(alpha-hydroxybenzhydryl)butyronitrile-->7-HYDROXYFLAVONE-->Benzopinacole |
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