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Glycidol

Glycidol

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Khoom Taw qhia

Cov ntaub ntawv tseem ceeb ntawm Glycidol
Khoom npe: Glycidol
Synonyms: GLYCEROLGLYCIDE;(+/-)-GLYCIDOL;GLYCIDOL;GLYCEROGLYCIDE;3-HYDROXY-1,2-EPOXYPROPANE;3-HYDROXYPROPYLENE OXIDE;2,3-EPOXY {9}}PROPANOL; 2, 3-EPOXYPROPAN-1-OL
CAS: 556-52-5
MF: C3H6O2
MW: 74.08
EINECS: 209-128-3
Khoom Categories: Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; 556-52-5
Mol File: 556-52-5.mol
Glycidol Structure
 
Glycidol Chemical Properties
Melting point -54 degree
Boiling point 61-62 degree / 15 mmHg (lit.)
ceev 1.117 g / mL ntawm 25 degree (lit.)
vapor ceev 2.15 (zeeg)
vapor siab 0.9 hli Hg (25 degree)
Refractive Index n20/D 1.433 (lit.)
Fp 178 degree F
cia temp. -20 degree
solubility Soluble hauv acetone, cawv, benzene, chloroform, thiab ether (Weast, 1986)
pka ua 14.62 ± 0.10 (Tswj)
daim ntawv Hmoov, Crystals los yog Chunks
xim Dawb rau lub teeb daj-beige
Dej Solubility soluble
Merck 13,4503
BRN 383562
Kev txwv tsis pub dhau TLV-TWA 75 mg/m3(25 ppm) (ACGIH); 150 mg/m3(50 ppm) (OSHA); IDLH 500 ppm (NIOSH).
Kev ruaj ntseg: Kev ruaj ntseg ruaj khov, tab sis tuaj yeem tawg ntawm kev sib cuag nrog cov kua qaub uas muaj zog, muaj zog hauv paus, hnyav hlau, hnyav hlau ntsev. Tej zaum yuav decompose thaum raug dej los yog huab cua noo.
InChIKey CTKINSOISVBQLD-UHFFFAOYSA-N
LogP -0.95 ntawm 25 degree
CAS DataBase Reference 556-52-5(CAS DataBase Reference)
NIST Chemistry Reference Glycidol (556-52-5)
IARC 2A (Vol. 77) 2000
EPA Tshuaj Registry System Glycidol (556-52-5)
 
Cov ntaub ntawv kev nyab xeeb
Hazard Codes T
Risk Statements 45-60-21/22-23-36/37/38-68
Cov lus hais txog kev nyab xeeb 53-45-36/37-26
RIDADR UN 2810 6.1/PG 3
OEB A
OEL TWA: 25 ppm (75 mg/m3)
WGK Germany 3
RTECS UB 4375000
F 10-21
Autoignition Kub 780 degree F
Ceeb toom Tshuaj lom
HazardClass 6.1(b)
PackingGroup III
HS Code 29109000
Cov Ntaub Ntawv Muaj Xwm Ceev 556-52-5(Cov ntaub ntawv muaj phom sij)
Toxicity Mob qhov ncauj LD50 rau nas 431 mg/kg, nas 420 mg/kg (quoted, RTECS, 1985).
IDLA 150 ppm ib
 
MSDS Cov Ntaub Ntawv
Tus kws kho mob Lus
ACROS Lus Askiv
SigmaAldrich Lus Askiv
 
Kev siv Glycidol thiab Synthesis
Kev piav qhia Glycidol yog chiral molecule nrog epoxide thiab thawj pawg cawv ua haujlwm. Nws yog sib xyaw racemic thiab muaj nyob rau hauv dextrorotatory thiab levorotatory enantiomeric cov ntaub ntawv. Muaj ntau txoj kev siv hluavtaws muaj rau kev npaj glycidol. Txawm li cas los xij, nws tau npaj ua lag luam los ntawm epoxidation ntawm allyl cawv nrog hydrogen peroxide thiab catalyst (tungsten lossis vanadium), lossis los ntawm cov tshuaj tiv thaiv ntawm epichlorohydrin nrog caustic. Glycidol tau siv rau hauv kev lag luam synthesis ntawm cov khoom siv tshuaj txij li xyoo 1970s. Txawm li cas los xij, nws siv rau kev tshawb fawb lub hom phiaj tau tshaj tawm txij li xyoo 1956. Cov ntaub ntawv muaj qhia tias glycidol yog tsim los ntawm ntau lub tuam txhab hauv Nyiv, Lub Tebchaws Yelemees, thiab Tebchaws Meskas.
Chemical Properties dej tsis muaj xim
Chemical Properties Glycidol yog cov kua tsis muaj xim.
Siv Glycidol yog siv los ua tus stabilizer rau natural oilsand vinyl polymers, ua demulsifier, thiab asa leveling tus neeg sawv cev rau dyes.
Siv Stabilizer hauv kev tsim cov vinyl polymers; intermediate nyob rau hauv synthesis ntawm glycerol, glycidyl ethers, thiab amines; additive rau roj thiab hluavtaws hydraulic kua; epoxy cob diluent.
Siv

Glycidol yog Stabilizer hauv kev tsim cov vinyl polymers; tshuaj intermediate hauv kev npaj ntawm glycerol, glycidyl ethers, esters, thiab amines; nyob rau hauv pharmaceuticals; nyob rau hauv sanitary tshuaj.
Txhais ib epoxide
Kev piav qhia dav dav Tsis muaj ntxhiab tsw ntshiab xim tsis muaj kua.
Cua & Dej Reactions Sensitive rau noo noo.
Reactivity Profile Glycidol yog rhiab heev rau ya raws. Glycidol kuj rhiab heev rau lub teeb. Glycidol tuaj yeem ua polymerize yog tias cua sov saum chav tsev kub. Glycidol tuaj yeem ua kom tsaus rau ntawm qhov chaw cia. Kev tshawb fawb txog kev ruaj ntseg ntawm Glycidol khaws cia rau ob lub lis piam tiv thaiv los ntawm lub teeb qhia meej meej decomposition ntawm 140 degree F, thiab qhia tau hais tias tsis ruaj khov ntawm 77 degree F. Ib qho kev daws ntawm Glycidol hauv dej tau pom tias tsis ruaj khov thaum khaws cia hauv chav sov, txawm tias tom qab ib hnub hauv qhov tsaus. Glycidol yog incompatible nrog muaj zog oxidizers. Glycidol yuav raug rhuav tshem thaum muaj cov kua qaub lossis cov hauv paus, ntsev (xws li txhuas chloride, hlau (III) chloride lossis tin (IV) chloride) lossis hlau (xws li tooj liab thiab zinc). Glycidol kuj tsis sib haum nrog nitrates. Glycidol yuav tawm tsam qee yam ntawm cov yas, roj hmab thiab txheej.
Hazard Cov khoom siv tshuaj lom. Tej zaum carcinogen.
Health Hazard Glycidol yog qhov muag, lub ntsws, thiab daim tawv nqaij irri-tant. Cov ntshiab compound ua rau mob hnyav tab sis thim rov qab qhov muag ntawm lub qhov muag luav (ACGIH 1986). Kev cuam tshuam rau nws cov vapor ua rau lub ntsws ua rau mob ntsws hauv nas, ua rau pneu-monitis. Tsis muaj pov thawj ntawm ib qho cumulative-tive toxicity. Los ntawm cov ntaub ntawv toxicity tsawg, nws zoo nkaus li tias kev noj qab haus huv muaj kev phom sij rau tib neeg los ntawm nws qhov tshwm sim yog, feem ntau, ua pa ua pa, stimulation ntawm lub hauv nruab nrab lub paj hlwb, thiab kev nyuaj siab.
Glycidol yog mutagenic, kuaj qhov zoo hauv histidine reversion-Ames kuaj. Tsis muaj ntawv tshaj tawm txog nws qhov kev ua carcinogenic. Oraland intraperitoneal kev tswj hwm ntawm gly-cidol hauv nas pom muaj kev phom sij rau kev xeeb tub.
Hluav Taws Xob Glycidol yog combustible.
Flammability thiab Explosibility Tsis yog nplaim taws
Kev ruaj ntseg Profile Cov ntaub ntawv pov thawj carcinogen nrog cov ntaub ntawv carcinogenic qhia. Tshuaj lom los ntawm txoj kev intraperitoneal. Mob hnyav heev los ntawm kev noj, nqus pa, thiab sh contact. Kev sim teratogenic thiab kev ua me nyuam. Ib daim tawv nqaij irritant. Human mutation data qhia. Tsiaj thwmsim qhia me ntsis toxicity tsawg dua rau cov epoxy compounds. Npaj txhij absorbed los ntawm daim tawv nqaij. Ua rau tshee excitation tom qab kev nyuaj siab. Thaum tshav kub kub los yog nyob rau hauv lub xub ntiag ntawm muaj zog acids, bases, hlau (xws li, tooj liab, zinc), thiab hlau ntsev (xws li, txhuas chloride, hlau (II1) chloride, tin (Iy chloride). Cov pa luam yeeb thiab pa taws.
Ntxim yuav nphav raug Glycidol yog siv los ua ib qho nruab nrab hauv kev sib txuas ntawm glycerol, glycidyl ethers, esters, thiab amines.
Carcinogenicity Glycidol yog qhov tsim nyog xav tias yuav yog tib neeg carcinogen raws li cov pov thawj txaus ntawm carcinogenicity los ntawm kev tshawb fawb hauv cov tsiaj sim.
Environmental txoj hmoo Tshuaj/Physical.Tej zaum yuav hydrolyze hauv dej tsim glycerin (Lyman li al., 1982).
Kev xa khoom UN2810 Toxic kua, organic, nos, Hazard Class: 6.1; Cov ntawv lo: 6.1-Cov ntaub ntawv muaj kuab lom, Kev Siv Lub Npe Yuav Tsum Tau.
Txoj Kev Purification [S(-)-isomer, § kuj muaj nyob rau ntawm kev txhawb nqa polymer, muaj b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(zoo)], [ R(+)-isomer muaj b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol los ntawm fractional distillation.
Kev tshuaj ntsuam toxicity Glycidol yog ib qho me me molecule uas muaj tshuaj lom neeg epoxide pawg. Yog li ntawd, nws ua raws li tus neeg sawv cev ncaj qha alkylating. Nucleophilic bioactive compounds xws li glutathione tuaj yeem nkag nrog glycidol. Glycidol txo glutathione cov ntsiab lus hauv nas lub siab los ntawm kev khi ncaj qha rau glutathione. Kev sim hauv vitro tau qhia tias glycidol reacts nrog purified DNA los tsim cov DNA adducts. Qhov no yuav yog lub luag haujlwm rau kev ua haujlwm genotoxic ntawm cov khoom sib txuas yam tsis tas yuav tsum muaj kev ua haujlwm metabolic.
Kev tsis sib haum xeeb Tej zaum yuav sib tov sib xyaw nrog cua. Cov tshuaj tiv thaiv muaj zog oxidizers, nitrates. Decomposes ntawm kev sib cuag (tshwj xeeb tshaj yog nyob rau hauv lub xub ntiag ntawm tshav kub) nrog muaj zog acids, muaj zog bases, dej, hlau ntsev, piv txwv li, alu minum chloride, ferric chloride, thiab tin chloride), los yog hlau (tooj liab thiab zinc), ua rau hluav taws kub thiab tawg txaus ntshai. . Kev sib cuag nrog barium, lithium, sodium, magnesium, thiab tita nium tuaj yeem ua rau polymerization. Tawm tsam qee yam yas, roj hmab, thiab txheej txheej.
Pov tseg pov tseg Concentrated pov tseg tsis muaj peroxides: tso kua dej ntawm tus nqi tswj nyob ze ntawm cov nplaim taws. Concentrated pov tseg uas muaj peroxides: perforation ntawm ib lub thawv ntawm cov pov tseg los ntawm qhov chaw nyab xeeb tom qab qhib hlawv.
 
Glycidol Preparation Products Thiab Raw Materials
Cov khoom nyoos Hydrogen peroxide-->Allyl alcohol-->Propylene glycol-->Peroxyacetic acid-->Tungstic acid-->(+/-)-1-GLYCEROL POLYSTYRENE-->Monoacetin-->Cov tshuaj Epichlorohydrin
Cov khoom npaj 2-METHYLUNDECANAL-->1,3-Dioxolane-4-methanol-->3-Methylamino-1,2-propanediol-->Glycidyl Palmitate-->MONOCAPRYLIN-->(2,3-dihydroxypropyl)trimethylammonium chloride-->MONOCAPRIN-->2, 3-dihydroxypropanesulphonic acid

Cim npe nrov: Tuam Tshoj glycidol manufacturers, lwm tus neeg, Hoobkas

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