Khoom Taw qhia
| Cyclopentanone Cov ntaub ntawv yooj yim |
| Cov khoom siv lub cev thiab tshuaj Lub hom phiaj tseem ceeb Cov Khoom Siv Tshuaj Ntau Lawm Cov Txheej Txheem Qib Toxicity grading Acute toxicity Cov ntaub ntawv irritation Flammability thiab cov yam ntxwv txaus ntshai Cia yam ntxwv Extinguishing agent |
| Khoom npe: | Cyclopentanone |
| Synonyms: | Adipinketon;Dumasin;Pyran-2,4(3H)-dione, 3-acetyl-6-methyl-;ADIPIC KETONE;AKOS BBS-00004293;KETOCYCLOPENTANE;KETOPENTAMETHYLENE;CYCLOPENTANONE |
| CAS: | 120-92-3 |
| MF: | C5H8O |
| MW: | 84.12 |
| EINECS: | 204-435-9 |
| Khoom Categories: | Pharmaceutical Intermediates; Organics; Alpha Sort; C; Volatiles / Semivolatiles; C3 txog C6; Cov Ntawv Sau Npe; CD; Flavors thiab Fragrances; Carbonyl Compounds; Ketones; 120-92-3; K00001 |
| Mol File: | 120-92-3.mol |
 |
|
| Cyclopentanone Chemical Properties |
| Melting point | -51 degree (lit.) |
| Boiling point | 130-131 degree (lit.) |
| ceev | 0.951 g/mL ntawm 25 degree (lit.) |
| vapor ceev | 2.97 (vs huab cua) |
| vapor siab | 11.5 hPa (20 degree) |
| FEMA | 3910|CYCLOPENTANONE |
| Refractive Index | n20/D 1.437 (lit.) |
| Fp | 87 degree F |
| cia temp. | Khaws hauv qab +30 degree . |
| solubility | 9.18g / l me ntsis soluble |
| daim ntawv | Ua kua |
| xim | Ntshiab xim tsis muaj xim kom daj me ntsis |
| tsw | Zoo siab |
| tawg txwv | 1.6-10.8%(V) |
| Hom tshuaj tsw qab | minty |
| Dej Solubility | YUAV TSUM INsolubLE |
| Merck | 14,2743 |
| JECFA Number | 1101 |
| BRN | 605573 |
| Dielectric tsis tu ncua | 16. 0(-49 degree) |
| Kev ruaj ntseg: | ruaj khov. Incompatible nrog muaj zog txo cov neeg ua haujlwm, muaj zog oxidizing cov neeg ua haujlwm, muaj zog hauv paus. |
| LogP | 0.7 ntawm 25 degree |
| CAS DataBase Reference | 120-92-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Cyclopentanone (120-92-3) |
| EPA Tshuaj Registry System | Cyclopentanone (120-92-3) |
| Cov ntaub ntawv kev nyab xeeb |
| Hazard Codes | Xi |
| Risk Statements | 10-36/38 |
| Cov lus hais txog kev nyab xeeb | 23 |
| RIDADR | UN 2245 3/PG 3 |
| WGK Germany | 1 |
| RTECS | wb 4725000 |
| Autoignition Kub | 445 degree |
| TSCA | Yog lawm |
| HS Code | 2914 29 00 |
| HazardClass | 3 |
| PackingGroup | III |
| Cov Ntaub Ntawv Muaj Xwm Ceev | 120-92-3(Cov ntaub ntawv muaj phom sij) |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| SigmaAldrich | Lus Askiv |
| ACROS | Lus Askiv |
| ALFA | Lus Askiv |
| Cyclopentanone Siv thiab Synthesis |
| Physical thiab Chemical Properties | Cyclopentanone tseem hu ua Adipic Ketono. Nws yog pob tshab tsis muaj xim oily kua. Nws muaj ntxhiab tsw ntawm ether tshwj xeeb thiab kuj me ntsis mint-smel. Nws muaj qhov txheeb ze molecular loj yog 84.12. Nws kuj muaj ib tug txheeb ze ntom ntom yog 0.9487, melting point yog -51.3 degree, boiling point yog 130.6 degree, 23 ~ 24 degree (1.333 X 103Pa), lub refractive index yog 1.4366, thiab flash point yog 30 degree. Nws yog insoluble hauv dej, soluble hauv cawv, ether thiab acetone. Nws yog narcotic nyob rau hauv high concentrations. Nws tuaj yeem tau txais los ntawm oxidation ntawm cyclopentanol. Nws tseem tuaj yeem tau txais los ntawm cua sov ntawm Adipic acid nyob rau hauv lub xub ntiag ntawm Barium hydroxide. Cyclopentanone kuj yooj yim raug rau polymerization tshwj xeeb tshaj yog nyob rau hauv muaj cov kua qaub. Nyob rau hauv rooj plaub ntawm cov cua sov, nws tuaj yeem koom nrog hauv cov tshuaj tiv thaiv lub cev qhuav dej hauv qab no, raws li tsim tawm 2-cyclopentylene cyclopentanone thiab 2'-cyclopentylene-2-cyclopentylene cyclopentanone: Hydrogenation tuaj yeem tsim ob-cyclopentanol nrog rau lub cev qhuav dej ntxiv ua 2, 2-tetramethylene cyclopentanone.  Cyclopentanone tsuas yog siv rau kev tsim tshuaj, tshuaj lom neeg, tshuaj tua kab thiab roj hmab additives. Aldehydes, ketones tuaj yeem hnov mob nrog diazoalkane thiab muaj cov nitrogen atoms poob, tsim ob lub tebchaw carbonyl thiab epoxy compounds. Thaum cov aldehydes, ketones molecules muaj cov pab pawg electron rho tawm, cov reactivity yog nce yuav boost lub tiam ntawm epoxy compound. Lub ketone molecule, nrog rau kev nce ntawm pawg hydrocarbon, kuj tseem tsim cov epoxy compound. Cyclic ketones, hloov pauv, yuav muaj lub nplhaib nthuav tawm. Qhov loj dua cov hydrocarbyl pawg ntawm diazoalkane yog, ntau cov carbonyl compounds tuaj yeem tau txais. Qhov kev txiav txim ntawm ketone reactivity yog raws li nws cov nucleophilic hloov kev txiav txim: Cl3CCOCH3> ClCH2COCH3> CH3COCH3> CH3COC6H5> cyclohexanone> cyclopentanone> cycloheptanone>Cyclooctanone. |
| Lub hom phiaj tseem ceeb | 1, Siv cov n-valeraldehyde thiab cyclopentanone ua raw khoom, thiab ua ntej mus rau aldol condensation cov tshuaj tiv thaiv thiab ntxiv lub cev qhuav dej cov tshuaj tiv thaiv kom tau pentylene cyclopentanone, ces ua raws li los ntawm kev xaiv catalytic hydrogenation kom tau pentyl cyclopentanone. Pentyl cyclopentanone muaj zog floral thiab fruity aroma nrog rau nuances ntawm jasmine. Nws tuaj yeem siv rau hauv kev tsim cov tshuaj tsw qab txhua hnub nrog kev siv nyiaj tsawg dua 20%. IFRA tsis muaj kev txwv. 2, Siv n-hexanal thiab cyclopentanone ua cov khoom siv raw, ua ntej muaj condensation, thiab tom qab ntawd ua cov tshuaj tiv thaiv hydrogenation kom tau txais hexyl cyclopentanone. Hexyl cyclopentanone muaj zog jasmine tsw nrog rau cov txiv hmab txiv ntoo nuances thiab tuaj yeem siv rau hauv cov tshuaj tsw qab thiab cov qauv ntawm lwm hom tshuaj tsw qab nrog kev siv nyiaj tsawg dua 5%. IFRA tsis muaj kev txwv. 3, Siv cov 1-pentene lossis 1-heptene tau los ntawm kev tawg ntawm paraffin los yog lub cev qhuav dej ntawm cov cawv sib xws raws li cov khoom siv raw, nyob rau hauv muaj t-butyl peroxide ua tus pib, muaj cov tshuaj tiv thaiv ntxiv ntawm cov pab pawg dawb radical nrog cyclopentanone, tsim 2-pentyl cyclopentanone (los yog 2-heptyl-cyclopentanone) nrog oxidation thiab lub nplhaib nthuav tawm los ua δ-lactone (lossis δ-Dodecalactone). 4 Synthesis txoj kev nrog cyclopentanone yog cov khoom pib yog cov khoom lag luam loj tshaj plaws. Cyclopentanone yog thawj zaug muaj aldol condensation cov tshuaj tiv thaiv nrog n-valeraldehyde nrog cov khoom ua kom lub cev qhuav dej ntxiv rau cov hws thiab cov hydrogenation xaiv los tsim 2-pentyl cyclopentanone. Thaum kawg nws dhau oxidation thiab lub nplhaib nthuav dav los ua δ-decalactone. 5, δ-decalactone feem ntau yog siv rau hauv kev tsim cov khoom noj qab zib. Nws yog suav hais tias nrog cov yam ntxwv tsw ntawm ntuj cream. Ua ntej nws tshwm sim, perfumers tau ntev tau txwv rau kev siv cov txuj lom monomer xws li butanedione thiab vanillin monomers los ua cov khoom tseem ceeb rau kev xa tawm ntawm butter tsw. Tab sis nws yog feem ntau pom tau hais tias cov formulated butter tsw yog phem dua li cov khoom ntuj nyob rau hauv kev hwm ntawm ob qho tib si saj los yog tsw respects. Tsuas yog tom qab siv δ-decalactone tuaj yeem muaj qhov tseeb qab zib, tshwj xeeb tshaj yog nyob rau hauv cov ntaub ntawv ntawm kev siv δ-Dodecalactone thiab δ-decalactone nyob rau hauv kev sib xyaw ua ke rau ua cov khoom siv tseem ceeb uas tuaj yeem txhim kho qhov tsw thiab cov nyhuv ntawm cov tshuaj qab zib. txuj lom. 6, Siv cyclopentanone thiab pentanal ua raw khoom, muaj condensation los tsim 2-(1-hydroxy) pentyl cyclopentanone uas yog ces reacted nrog dimethyl malonate thiab hydrolyzed ntawm 160 ~ 180 degree, mus los ntawm decarboxylation, esterification rau Tau txais methyl dihydrojasmonate. Methyl dihydrojasmonate yog cov khoom qab zib uas tau muab los ntawm GB 2760-1996 ntawm Tuam Tshoj rau daim ntawv thov ib ntus. Nws aroma yog zoo dua li ntuj methyl jasmonate. Nws cov cuab yeej kuj tseem ruaj khov. Cov ntaub ntawv saum toj no yog kho los ntawm chemicalbook ntawm Dai Xiongfeng. |
| Chemical Properties | Nws yog xim tsis muaj xim, oily kua nrog qab ntxiag mint tsw. Nws muaj qhov melting point ntawm {{0}}.2 degree, boiling point ntawm 130.6 degree, tus txheeb ze ceev ntawm 0.9509 (20 degree), lub refractive index ntawm 1.4366 thiab lub flash point ntawm 29.82 degree . Nws yog miscible nrog ethanol, ethyl ether thiab me ntsis soluble hauv dej. Nws yog ib qho yooj yim rau undergo polymerization, tshwj xeeb tshaj yog nyob rau hauv cov ntaub ntawv ntawm cov kab mob ntawm cov kua qaub. |
| Txoj kev tsim khoom | Nws tuaj yeem tau txais los ntawm cua sov ntawm Adipic acid nyob rau hauv lub xub ntiag ntawm barium hydroxide. Sib tov cov barium hydroxide thiab adipic acid uniformly thiab tshav kub mus rau 285-295 degree, ntxiv distilled tawm cov generated cyclopentanone ntawm qhov kub no. Lub distilled calcium chloride yog salted tawm rau kev cais cov cyclopentanone; ntxiv qhov tsim nyog cov tshuaj alkaline kom tshem tawm cov adipic acid ntxuav, ces ntxuav nrog dej; qhuav nrog anhydrous calcium chloride; muaj distillation; sau cov feem hauv 128-131 degree kom tau cov khoom tiav nrog cov txiaj ntsig yog 75-80%. |
| Qeb | Flammable kua |
| Toxicity grading | lom |
| Mob toxicity | Intraperitoneal-nas LD50: 1950 mg/kg; subcutaneous-Mouse LD50: 2600 mg/kg. |
| Cov ntaub ntawv khaus | Daim tawv nqaij-liab 500 mg Me; Qhov muag-luav 100 mg hnyav. |
| Flammability thiab phom sij | Nws yog flammable nyob rau hauv cov ntaub ntawv ntawm hluav taws kub, siab kub thiab nrog burning ua burnt pa taws. |
| Cov yam ntxwv khaws cia | Cov nyiaj txiag: qhov cua, qhov kub thiab txias; khaws nws cais los ntawm oxidants thiab acids. |
| Extinguishing tus neeg sawv cev | Cov hmoov qhuav, xuab zeb qhuav, carbon dioxide, ua npuas ncauj, 1211 tus neeg tua hluav taws tua hluav taws. |
| Chemical Properties | Cyclopentanone yog cov kua tsis muaj xim nrog lub qab ntxiag, me ntsis pepperminty tsw. Nws yog soluble hauv dej thiab miscible nrog cov organic solvents. Cyclopentanone muaj qhov pom zoo, zoo li peppermint tsw. Nws zoo li polymerize nyob rau hauv lub xub ntiag ntawm acids. |
| Qhov tshwm sim | Tshaj qhia pom nyob rau hauv roasted dos, ci qos yaj ywm, txiv lws suav, gruyere cheese, butter, rhuab nqaij qaib, boiled nqaij nyuj, rhuab nqaij npuas, roasted pecan, daj passion txiv hmab txiv ntoo kua txiv. |
| Siv | Cyclopentanone yog siv los ua ib qho nruab nrab hauv kev sib txuas ntawm cov nplaum nplaum, cov khoom siv hluavtaws, cov tshuaj thiab cov tshuaj lom neeg lom neeg. Nws ua haujlwm ua ntej rau kev npaj ntawm cyclopentamine thiab tseem pentethylcyclanone, cyclopentobarbital. Nws yog ib qho tseem ceeb hauv chav kuaj reagent thiab siv ua thinner rau epoxy. Nws kuj tseem siv tau los ua cov kuab tshuaj hauv cov xim thiab cov kua roj vanish tshem tawm thiab siv hluav taws xob siv. Raws li tus neeg saib xyuas qhuav, nws yog siv rau cov roj extraction. Nws kuj tseem koom nrog hauv kev npaj ntawm cyclopentanone derivatives zoo li cyclopenylamine thiab cyclopentanol uas pom daim ntawv thov hauv kev lag luam naj hoom. |
| Kev npaj | Npaj los ntawm cua sov adipic acid (285 mus rau 295 degree) nyob rau hauv lub xub ntiag ntawm barium hydroxide, distilling, ether extraction thiab ces fractionation. |
| Txhais | ChEBI: Ib qho cyclic ketone uas muaj cyclopentane bearing ib qho oxo hloov pauv. |
| Aroma pib qhov tseem ceeb | Aroma yam ntxwv ntawm 2. |
| Saj pib qhov tseem ceeb | Cov yam ntxwv saj ntawm 20 ppm: musty, toasted nutty nrog me ntsis meaty nuance. |
| Kev piav qhia dav dav | Cov kua ntshiab tsis muaj xim nrog cov ntxhiab tsw zoo li roj av. Flash point 87 degree F. Tsawg ntom dua dej thiab insoluble hauv dej. Vapors hnyav dua li huab cua. |
| Cua & Dej Reactions | Cov nplaim taws heev. Insoluble hauv dej. |
| Reactivity Profile | Cyclopentanone polymerizes yooj yim, tshwj xeeb tshaj yog nyob rau hauv lub xub ntiag ntawm acids. Nws tuaj yeem cuam tshuam nrog cov khoom siv oxidizing, piv txwv li hydrogen peroxide. |
| Health Hazard | Kev nqus tau los yog sib cuag nrog cov khoom yuav ua rau khaus lossis hlawv tawv nqaij thiab qhov muag. Hluav taws yuav ua rau khaus, corrosive thiab/los yog cov pa phem. Vapors tuaj yeem ua rau kiv taub hau lossis ua tsis taus pa. Cov dej ntws los ntawm kev tswj hluav taws kub lossis dej dilution tuaj yeem ua rau muaj kuab paug. |
| Kev ruaj ntseg Profile | Muaj tshuaj lom los ntawm intraperitoneal thiab subcutaneous txoj hauv kev. Ib daim tawv nqaij thiab qhov muag heev irritant. Kev phom sij phom sij thaum raug tshav kub lossis nplaim taws; tuaj yeem cuam tshuam nrog oxidizers. Txhawm rau tua hluav taws, siv cawv ua npuas ncauj, ua npuas ncauj, CO2, tshuaj qhuav. Muaj peev xwm tawg cov tshuaj tiv thaiv nrog hydrogen peroxide + nitric acid. Thaum rhuab mus rau decomposition nws emits pa taws thiab fumes. Saib KETONES thiab. |
| Txoj kev Purification | Co nws nrog aqueous KMnO4 kom tshem tawm cov ntaub ntawv nqus ntawm 230 txog 240nm. Qhuav nws nrog Linde-hom 13X molecular sieves thiab fractionally distil nws. Nws kuj tau raug ntxuav los ntawm kev hloov pauv mus rau NaHSO3 adduct uas, tom qab crystallising plaub zaug ntawm EtOH / dej (4: 1), yog decomposed los ntawm kev ntxiv rau qhov sib npaug ntawm Na2CO3 hauv kub H2O. Cov dawb cyclopentanone yog chav distilled los ntawm cov tshuaj. Cov distillate yog saturated nrog NaCl thiab muab rho tawm nrog * benzene uas yog ces qhuav (anhydrous K2CO3) thiab evaporated. Cov residue yog tom qab ntawd distilled [Allen, et al. J Chem Soc 1909 1960]. [Beilstein 7 IV 5.] |
| Cyclopentanone Npaj Cov Khoom Siv thiab Cov Khoom Raw |
| Cov khoom siv raw | Calcium chloride-->Adipic acid-->Barium hydroxide |
| Cov khoom npaj | Sebacic acid-->BENZOFURAN-5-BORONIC ACID-->Cyclopentane-1,1-diacetic acid-->Glutaric acid-->SPIRO[4.5]DECANE-7,9-DIONE-->Buspirone-->Allethrin-->1-CYCLOPENTYLIDENE-PROPAN-2-ONE-->2-Cyclopenten-1-one-->1-Bromo-1-cyclopentene-->3-(4-OXO-3,5,6,7-TETRAHYDRO-4H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDIN-2-YL)PROPANOIC ACID-->1-Cyclopentenecarboxylic acid-->Bromocyclopentane-->Cyclopentane-->Pencycuron-->(4-OXO-6,7-DIHYDRO-4H,5H-CYCLOPENTA[4,5]THIENO-[2,3-D]PYRIMIDIN-3-YL)-ACETIC ACID-->Cyclopentanol-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXAMIDE-->CYCLOLEUCINOL-->Ethyl 2-oxocyclopentylacetate-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBONITRILE-->1,2,3,5-TETRAHYDRO-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE-4-ONE-->2,2-DIMETHYLCYCLOPENTANONE-->Cyclopenta[b]pyridine-->CYCLOPENTANETHIOL-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER-->Methyl cyclopentenolone-->1-CYANOCYCLOPENTENE-->Methyl dihydrojasmonate-->delta-Valerolactone-->5-(4-Chlorobutyl)-1-cyclohexanyl tetrazole |
Cim npe nrov: Tuam Tshoj cyclopentanone manufacturers, lwm tus neeg, Hoobkas
Tug: Glycolic acid
Tom ntej: DIETHYLENEGLYCOL METHYL-TERT-BUTYL ETHE
Koj Tseem Yuav Zoo Li
Xa kev nug
