| Chemical Properties |
daj crystalline khoom
 |
| Siv |
2,5-Dimethoxybenzaldehyde yog siv rau hauv kev npaj ntawm 2,5-dimethoxyphenethylamine, uas yog siv los npaj cov tshuaj psychoactive xws li 2,5-dimethoxy-4-bromophenethylamine, 2,{ {8}}dimethoxy-4-iodophenethylamine thiab 4-Chloro{11}}, 5-dimethoxy-phenethylamine. Nws ua raws li qhov nruab nrab hauv cov organic synthesis. |
| Daim ntawv thov |
2,5-Dimethoxybenzaldehyde, tseem hu ua 2C-H, yog cov organic compound thiab benzaldehyde derivative. Nws tuaj yeem siv los tsim 2, 5-dimethoxyphenethylamine. 2C-H kuj tseem siv los tsim ntau lwm cov tshuaj phenethylamines xws li 2C-B, 2C-I thiab 2C-C. |
| Kev npaj |
2. O-formyl-4-methoxyphenol tau txais txoj kev no yog hydrolyzed . 4-Methoxyphenol yog tom qab formylated siv txoj kev Reimer-Tiemann thiab tau txais 2-hydroxy-5-methoxybenzaldehyde yog methylated nrog dimethylsulfate rau 2,5-dimethoxybenzaldehyde.
Kev tshwm sim
A: Anisaldehyde los ntawm anethole ntawm oxidative cleavage: 20 g anise roj raug tshem tawm nyob rau hauv ib tug sib tov ntawm 150 mL dej thiab 30 mL conc. sulfuric acid; Ntxiv ntawm 55 g sodium bichromate ntawm tus nqi uas qhov kub tsis tshaj 40 degree. Cov tshuaj tiv thaiv sib tov tau muab rho tawm nrog 4 x 125 mL toluene thiab cov kuab tshuaj evaporated. Cov roj residual yog lub tshuab nqus tsev distilled kom tawm los 9.1 g anisaldehyde.
B: O-formyl-4-methoxyphenol: 6 mL anisaldehyde tau yaj hauv 75 mL dichloromethane (DCM). Sib tov ntawm 12 g hydrogen peroxide thiab 10 mL conc. formic acid tau ntxiv tshaj 30 min. Cov tshuaj tiv thaiv sib xyaw tau maj mam refluxed rau 21 teev.
C: B 4-methoxyphenol: Evaporating cov kuab tshuaj los ntawm cov tshuaj tiv thaiv sib tov thiab noj cov residue nyob rau hauv 100 mL aqueous NaOH (20%) (25 mL MeOH as co-solvent) yielded 4.1 g 4-methoxyphenol li a dawb crystalline khoom tom qab ib txwm ua hauj lwm-up thiab purification cov kauj ruam.
D: Reimer-Tiemann formylation ntawm 4-methoxyphenol: 124.1 g 4-methoxyphenol tau yaj hauv cov tshuaj NaOH (320 g NaOH hauv dej 400 mL). Hauv tag nrho, 161 mL chloroform tau ntxiv. Kev ua hauj lwm ib txwm ua thiab chav distillation tau txais 109.8 g ntawm cov roj ntshiab daj uas tsis khov thaum sawv ntawm chav sov (GC / MS: 94% 2-hydroxy-5-methoxybenzaldehyde).
E: D Methylation ntawm 2-hydroxy-5-methoxybenzaldehyde: Cov roj daj los ntawm tau siv yam tsis muaj kev lim dej ntxiv. Ib lub raj mis 250 mL RB tau them nrog 100 mL acetone, 14 g anhydrous potassium carbonate thiab 10 g 2-hydroxy-5-methoxybenzaldehyde; Qhov sib tov tau coj los ntawm qhov kub thiab txias thiab 11 g dimethyl sulfate ntxiv. Cov tshuaj tiv thaiv tau txuas ntxiv rau 4 teev. Cov kuab tshuaj yog evaporated thiab cov khoom crude kawg crystallized nyob rau hauv dej txias. Recrystallization los ntawm EtOH/dej yielded 8.3 g 2,5-dimethoxybenzaldehyde (GC/MS: 98%+ 2,5-dimethoxybenzaldehyde) |
| Txhais |
ChEBI: 2, 5-dimethoxy-Benzaldehyde yog dimethoxybenzene. |
