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2,2'-Bipyridine

2,2'-Bipyridine

Xa kev nug

Khoom Taw qhia

2,2'-Bipyridine Cov ntaub ntawv yooj yim
Khoom npe: 2,2'-Bipyridine
Synonyms: 2,6'-Bipyridine;bpy;2,2-Bispyridine;2,2'-Dipyridyl pa;2,2'-BIPYRIDINE (2,2'-Bipyridyl);2'-Bipyridine;2,{{ 17}}Dipyridyl 99+%, Dawb Crystalline hmoov, Reagent Qib; , '-Dipyridyl, 2,2'-Dipyridyl
CAS: 366-18-7
MF: C10H8N2
MW: 156.18
EINECS: 206-674-4
Khoom Categories: Aromatics; Analytical Chemistry; Pyridine; Pyridines derivates; Bipyridyls, thiab lwm yam Protease Inhibitors; C9 rau C46Derivatization Reagents TLC; TLC Reagents, D-FDerivatization Reagents TLC; Hlau IonsTitration; TLC Reagents, A-CSpectroscopy; Derivatization Reagents TLC; Qhov Ntsuas; Redox IndicatorsDerivatization Reagents TLC; TLC Visualization Reagents (daim ntawv thov) ; UV / Vis Reagents; UV / Visible (UV / VIS) Spectroscopy; A-BAlphabetic; Alpha sort; Heterocyclic Building Blocks; Pyridines; Vitamins; Achiral Nitrogen; Py-N; B; BI - BZ; Tshuaj tua kab & Metabolites; {{7} }
Mol File: 366-18-7.mol
2,2'-Bipyridine Structure
 
2,2'-Bipyridine Cov Khoom Siv Tshuaj
Melting point 70-73 degree (lit.)
Boiling point 273 degree (lit.)
ceev 1.1668 (kev kwv yees kwv yees)
vapor siab 0.584Pa ntawm 25 degree
Refractive Index 1.4820 (kwv yees)
Fp 121 degree
cia temp. chav kub
solubility 5.5g/l
pka ua pK1:-0.52(+2);pK2:4.352(+1) (20 degree)
daim ntawv Crystalline hmoov
xim Dawb mus yuav luag dawb
PH 7.5 (5g / l, H2O, 25 degree)
tsw Cov yam ntxwv tsw
Dej Solubility 5.5 g/L 22 ºC
Merck 14,3347
BRN 113089
Kev ruaj ntseg: ruaj khov. Incompatible nrog muaj zog oxidizing neeg sawv cev, feem ntau cov hlau. Tej zaum yuav lub teeb rhiab heev.
InChIKey ROFVEXUMMXZLPA-UHFFFAOYSA-N
CAS DataBase Reference 366-18-7(CAS DataBase Reference)
NIST Chemistry Reference 2,2'-Bipyridine (366-18-7)
EPA Tshuaj Registry System 2,2'-Bipyridine (366-18-7)
 
Cov ntaub ntawv kev nyab xeeb
Hazard Codes T, Xis
Risk Statements 25-36/37/38-20/21-23/24/25-21
Cov lus hais txog kev nyab xeeb 36/37-45-36/37/39-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DW1750000
F 8
Ceeb toom Irritant
TSCA Yog lawm
HazardClass 6.1
PackingGroup III
HS Code 29333999
Cov Ntaub Ntawv Muaj Xwm Ceev 366-18-7(Cov ntaub ntawv muaj phom sij)
Toxicity LD50 ip hauv nas: 200 mg / kg (Grady)
 
MSDS Cov Ntaub Ntawv
Tus kws kho mob Lus
2,2'-Bipyridine Lus Askiv
SigmaAldrich Lus Askiv
ACROS Lus Askiv
ALFA Lus Askiv
 
2,2'-Bipyridine Siv Thiab Synthesis
Chemical Properties Dawb rau lub teeb liab crystalline hmoov. Soluble nyob rau hauv ethanol, ether, benzene, chloroform thiab roj av ether, 1 feem ntawm cov khoom no yog hais txog 200 qhov chaw ntawm dej.
Siv Ib tug high-affinity chelator ntawm hlau. Ib qho reagent siv rau kev txiav txim siab ntawm hlau.
Siv 2,2'-bipyridine ua raws li bidentate chelating ligand uas tsim cov complexes nrog kev hloov pauv hlau ions thiab qhia txog kev tiv thaiv kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob. Nws yog siv rau kev txiav txim siab colorimetric ntawm hlau nrog rau cov ntsuas oxidation txo kom paub meej tias muaj ferrous ion hauv cov av. Nws tsim cov complexes nrog ruthenium thiab platinum, nthuav tawm luminescence khaus, uas tej zaum yuav muaj kev siv tau. Copper (I) bipyridine complexes koom nrog oxidation ntawm cawv nyob rau hauv aerobic tej yam kev mob.
Txhais ChEBI: 2,2'-bipyridine yog ib qho bipyridine uas ob lub pyridine moieties txuas los ntawm kev sib txuas ntawm txoj haujlwm C-2 thiab C-2'. Nws muaj lub luag haujlwm ua ferroptosis inhibitor thiab chelator.
Kev npaj 2,2'-bipyridine yog tsim los ntawm cov tshuaj tiv thaiv ntawm pyridine nrog ferric chloride. Noj 70g ntawm anhydrous pyridine thiab sib tov nrog 13g ntawm anhydrous ferric chloride, tshav kub thiab react ntawm 300 degree nyob rau hauv ib lub raj kaw rau txog 35h. Tom qab txias, cov reactant solidified rau hauv liab-dub crystals, lub sealing raj tau qhib, thiab cov kua liab-dub ntawm cov khoom raug ntxuav tawm nrog ib tug me me ntawm cov dej kub. Cov roj impurities raug tshem tawm los ntawm kev rho tawm nrog ether. Tom qab neutralization nrog sodium bicarbonate, ntau tshaj pyridine raug tshem tawm los ntawm cua sov nrog chav. Tom qab ntawd qhov sib tov tau ua kom yooj yim, thiab 2,2'-bipyridine tau distilled nrog chav.
Cov tshuaj tiv thaiv Ntau cov complexes ntawm 2,2'-bipyridine tau piav qhia.Nws khi cov hlau ua ib qho chelating ligand, tsim ib lub nplhaib chelate.
Synthesis Reference (cov) Phau ntawv Journal of the American Chemical Society, 100, p. 5567, 1978 ibDOI:10.1021/ja00485a053
Synthesis, p. 564 Ib., 1986DOI: 10.1055/s-1986-31705
Kev piav qhia dav dav 2,2′-Bipyridyl, yog ib tug symmetrical bipyridine feem ntau siv raws li ib tug nruab nrab ligand rau complexation nrog hlau ions. Lub molecule yog planar nrogtrans-conformation thiab crystallizes nyob rau hauv lub monoclinic crystal system.
Biochem/physiol Actions Metalloprotease inhibitor, high-affinity chelator ntawm hlau; tej zaum yuav inhibit Fe2+ uas muaj enzymes ntawm 10?8?M.
Kev ruaj ntseg Profile Tshuaj lom los ntawm kev noj, subcutaneous, thiab intraperitoneal txoj kev. Experimentalteratogenic cov ntaub ntawv. Cov lus nug carcinogen nrog kev sim cov ntaub ntawv tumorigenic. Cov ntaub ntawv hloov pauv tau tshaj tawm.Thaum rhuab mus rau decomposition nws tawm cov pa phem ntawm NOx.
Qhov chaw 2,2'-Bipyridine yog ib yam khoom ntuj tsim nyob rau hauv Dichilus strictus, Dichilus gracilis, thiab lwm yam kab mob uas muaj ntaub ntawv.
Txoj Kev Purification 2,2'-Bipyridyl crystallises los ntawm hexane, los yog EtOH, los yog (tom qab charcoal kho ntawm ib tug CHCl3 tov) los ntawm tsiaj ether. Tsis tas li ntawd, nws precipitates los ntawm cov tshuaj concentrated hauv EtOH los ntawm kev ntxiv ntawm H2O. Qhuav nws hauv lub tshuab nqus tsev tshaj P2O5. Nws tuaj yeem ua kom huv ntxiv los ntawm chromatography ntawm Al2O3 lossis los ntawm sublimation. UV (EtOH): ntawm 280nm (log 4.13). max [Airoldi et al. J Chem Soc, Dalton Trans 1913 1986, Beilstein 23 H 199, 23/8 V 16.]
 
2,2'-Bipyridine Kev Npaj Cov Khoom Siv thiab Cov Khoom Raw
Cov khoom nyoos Ferric chloride-->2-Picoline-->5-METHYL-2,2'-BIPYRIDYL-->5,5'-DIMETHYL-2,2'-DIPYRIDYL-->2-Bromopyridine-->Neocuproine-->TRIETHYOXY-2-THIENYLSILANE 97
Cov khoom npaj Tetrahydro-4H-pyran-4-one-->1,1'-Bis (di-t-butylphosphino)ferrocene palladium dichloride,-->1,1'-Bis(di-tert-butylphosphino)ferrocene-->3-(DIMETHYLCARBAMOYL)PHENYLBORONIC ACID-->4-(Dimethylamino)phenylboronic acid-->TRIS(2,2'-BIPYRIDYL)RUTHENIUM(II) CHLORIDE HEXAHYDRATE-->4,4'-DIBROMO-2,2'-BIPYRIDINE-->2,2'-BIPYRIDINE-4-CARBALDEHYDE-->(2,2'-BIPYRIDINE)DICHLOROPALLADIUM(II)

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