| Chemical Properties |
2-amino-1, 3-propanediol, uas yog lub npe tsis tseem ceeb ntawm serinol, yog cov organic compound los ntawm pawg alkanolamines.Lub npe serinol raug xaiv vim yog cov qauv zoo sib xws rau cov amino acidserine. Hauv kev txuas ntxiv, derivatives ntawm no nrog cov khoom hloov pauv ntawm cov carbons ntawm serinol kuj hu ua serinols.Raws li cov txheej txheem, nws yog ib qho khoom, uas yog soluble hauv dej. 2-amino-1, 3-propanediol yog ib yam khoom ruaj khov, hygroscopic thiab corrosive. |
| Daim ntawv thov |
Hauv kev ua liaj ua teb lom neeg, cov qauv amino cawv tau dav pom hauv ntau cov tshuaj tshwj xeeb tshaj yog cov tshuaj tiv thaiv kab mob.
Serinol yog siv los ua ib qho nruab nrab rau cov uas tsis yog-ionic X-ray contrast agents xws li iopamidol (1-N,3-N-bi's (1,3-dihydroxypropan-2-}yl) { {8}}[(2S) -2-hydroxypropanamido] -2,4,6-triiodobenzene-1,3-di-carboxamide, uas yog piv txwv faib raws li iopamiro®, isovue® (ob leeg Bracco Diagnostics Inc.) lossis scanlux® (Sanochemia).
Tsuas yog daim ntawv thov hauv biochemical teb, Serinol yog siv rau kev tsim cov anionic emulsifiers thiab nonionic polyethylene emulsions. Nws tshwm sim nyob rau hauv cov khoom tsim kho tus kheej thiab qhia tau hais tias zoo zog lub hauv paus, qis nruab nrab sib npaug, thiab qis volatility dua li cov tshuaj amine emulsifiers. Tsis tas li ntawd, serinol yog ib tug precursor rau tshuaj kho mob.
Lub difunctionality ntawm serinol ua rau nws pab tau raws li raw cov ntaub ntawv nyob rau hauv polymer daim ntaub ntawv nyob rau hauv ob qho tib si dej- thiab hnyav-raws li mus nce solubility ntawm lwm yam Cheebtsam thiab txhim kho cov tshuaj stability. Nws ua haujlwm raws li pigment dispersion-pab dispersant los txhim kho cov ntub dej thiab viscosity stability.
Serinol tswj cov alkalinity tas li nyob rau hauv cov dej npau npau thiab condensate tsis tsim cov khoom uas yuav cuam tshuam cov kab khiav. Nws yog siv rau corrosion Inhibits. Yog li nws yog dav siv nyob rau hauv kev npaj ntawm dej soluble cationic flocculants thiab ion pauv resins uas adsorb khoom thiab colloidal hais los ntawm electrostatic attraction. Nws kuj yog siv rau kev kho dej, kho hlau thiab nqus cov pa CO2.
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| Kev piav qhia |
2-Amino-1,3-propanediol (2-APD, tseem hu ua serinol) yog cov tshuaj muaj txiaj ntsig zoo ntxiv uas yog siv los ua lub tsev thaiv kev sib txuas ntawm ntau yam sib txuas, suav nrog cov tshuaj los kho hom 2 mob ntshav qab zib mellitus, tshuaj tua kab mob chloramphenicol, tiv thaiv kab mob ntau yam sclerosis, thiab tiam tshiab ntawm nonionic X-ray contrast agents. |
| Chemical Properties |
dawb mus rau dawb-dawb adhering crystalline hmoov |
| Siv |
2-Amino-1,3-propanediol yog siv los ua ib qho nruab nrab hauv ntau daim ntawv thov tshuaj thiab tseem muaj txiaj ntsig rau serinol thiab qee yam ntawm nws cov derivatives. |
| Siv |
Serinol tuaj yeem siv los npaj cov khoom siv nucleic acids. Nws tuaj yeem siv rau hauv kev sib xyaw ua ke ntawmN-acylated serinol thiab C16-serinol affinity gel. |
| Kev npaj |
Ntxiv 20% 2-nitro-1, 3-propanediol methanol tov (1250 g) rau 5% palladium / carbon 3.5 g. Hydrogen (70 L, siab 3MPa) tau qhia tsis tu ncua thiab hnov mob ntawm 75 degree rau 5 teev kom tau txais cov tshuaj cawv serine. Cov tshuaj serine cawv yog muab tso rau hauv lub tshuab nqus tsev distillation siab, nqus mus rau 40 pa, thiab methanol yog distilled rau rov siv dua. Yield=97.2%. |
| Biosynthesis |
Tam sim no, kev tsim khoom ntawm 2-Amino-1, 3-propanediol (2-APD) feem ntau tso siab rau cov txheej txheem tshuaj lom neeg los ntawm kev siv cov roj fossil tau txais thiab cov khoom siv tawg heev. Ntxiv nrog rau cov tshuaj synthesis, nws cov synthesis tuaj yeem tso siab rau biosynthesis. Luo et al. tau tsim ib txoj hauv kev tsim khoom biosynthetic rau kev hloov cov piam thaj mus rau 2-APD hauv cov metabolism hauv Escherichia coli. Txoj kev dag no ntiav ib qho kev tsim kho heterogeneous aminotransferase RtxA rau diverting dihydroxyacetone phosphate (DHAP) los tsim 2-APD phosphate thiab endogenous phosphatase rau hloov mus rau hauv cov khoom lag luam phiaj xwm 2-APD. 2-APD-P yog 2-amino-1, 3-propanediol phosphate[1]. |
| Keeb kwm |
Hauv xyoo 1970, 2-Amino-1, 3-propanediol (2-APD) tau tshaj tawm thawj zaug los ua ib lub tsev molecular block ntawm cov khoom ntuj tsim rhizobitoxine thiab dihydrorhizobitoxine tsim los ntawm legume symbiont Rhizobium japonicum [1]. |
| Kev piav qhia dav dav |
Serinol activates toxin ntau lawm nyob rau hauv lub attenuated kab lis kev cai ntawmHelminthosporium cov sacchari. Kev npaj ntawm polyesters muab los ntawm serinol tau tshaj tawm. |
| Cov ntaub ntawv |
[1] Luo Y, et al. Txoj Kev Artificial Biosynthetic rau 2?Amino-1,3-Propanediol Production Siv Metabolically Engineered Escherichia coli. ACS Synthetic Biology, 2019; 8: 548–556. |
