Khoom Taw qhia
| HEXAMETHONIUM BROMIDE Cov ntaub ntawv yooj yim |
| Khoom npe: | HEXAMETHONIUM BROMIDE |
| Synonyms: | gangliostat; hexamethioniumbromide; hexamethylenebis (trimethyl-ammoniudibromide; hexameton; hexoniumdibromide; simpatoblock; Methobromine; Hexamethonium bromide, Hexamethonium bromide, Hexane-1, 6-bis(trimethylam', N', N', N, , N'-Hexamethylhexamethylenediammonium dibromide |
| CAS: | 55-97-0 |
| MF: | C12H30Br2N2 |
| MW: | 362.19 |
| EINECS: | 200-249-7 |
| Khoom Categories: | Ammonium Bromides (Quaternary); Quaternary Ammonium Compounds |
| Mol File: | 55-97-0.mol |
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| HEXAMETHONIUM BROMIDE Cov Khoom Siv Tshuaj |
| Melting point | ~ 285 degree (lub kaum hli ntuj) |
| cia temp. | Inert cua, Chav Kub |
| solubility | Dej (me ntsis) |
| daim ntawv | Crystalline hmoov thiab agglomerates |
| xim | Dawb |
| PH | pH (20g / l, 25 degree): 4 |
| Merck | 14,4688 |
| BRN | 3715749 |
| InChIKey | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| CAS DataBase Reference | 55-97-0(CAS DataBase Reference) |
| EPA Tshuaj Registry System | 1,6-Hexamethyl-, bromide (1: 2) ({11}}) |
| Cov ntaub ntawv kev nyab xeeb |
| Cov lus hais txog kev nyab xeeb | 22-24/25 |
| WGK Germany | 2 |
| RTECS | wb 8575000 |
| TSCA | Yog lawm |
| HS Code | 29239000 |
| MSDS Cov Ntaub Ntawv |
| Tus kws kho mob | Lus |
|---|---|
| SigmaAldrich | Lus Askiv |
| HEXAMETHONIUM BROMIDE Siv thiab Synthesis |
| Kev piav qhia | Hexamethonium yog ib qho peripheral-acting nondepolarizing neuromuscular thaiv tus neeg sawv cev uas ua raws li tus antagonist ntawm nicotinic acetylcholine receptors (nAChRs). Nws txo qis acetylcholine tso tawm induced los ntawm carbamoylcholine nyob rau hauv cais miv superior cervical ganglion thaum siv nyob rau hauv ntau ntawm 27.4 thiab 54.8 ug / ml. Nws kuj tseem txo qis cov ntshav siab hauv cov nas uas tsis muaj tshuaj loog thaum noj ntawm koob tshuaj 40 mg / kg. Intraventricular kev tswj hwm ntawm hexamethonium (18 ng, icv) induces cov cim ntawm nicotine abstinence, nrog rau co, writhing, thiab zom nyob rau hauv nicotine-dependent nas. Cov formulations uas muaj hexamethonium yav tas los tau siv rau hauv kev kho mob ntshav siab. |
| Chemical Properties | Dawb crystalline hmoov thiab agglomerates |
| Keeb kwm | Bistrium, Squibb, Asmeskas, 1951 |
| Siv | Hexamethonium bromide tau siv: raws li tus neeg sawv cev ntawm ganglia-txhim kho tus neeg saib xyuas los kawm txog nws cov teebmeem ntawm kev txav txav ntawm cov nas raws li nicotinic receptor antagonist los kawm txog nws cov teebmeem ntawm antigen-induced arthritis (AIA) kev loj hlob hauv cov nas. raws li ib tug tsis xaiv ganglionic nicotinic acetylcholine receptor (nAChR) antagonist los kawm txog nws cov teebmeem ntawm cytisine-induced autonomic cardiovascular teb nyob rau hauv nas. |
| Kev tsim khoom | Hexamethylene diamine (116 g), sodium carbonate (466 g), thiab dej (80}0 ml) tau rhuab mus rau 60 degree, thiab dimethyl sulfate (830 g) ntxiv nrog nplawm tshaj 1% teev ua kom kub hauv qab no. 90 degree. Tom qab ntawd cov tshuaj sib tov sib xyaw yog nplawm ntawm 90 degree rau 2 teev, tom qab ntawd txias rau 20 degree, acetone (1,200 ml) ntxiv thiab tag nrho txias rau 0 degree. Cov khoom tsim tau raug tshem tawm los ntawm kev pom thiab ntxuav nrog acetone (150 ml). Lim thiab ntxuav tau diluted nrog dej mus rau 4 litres thiab rhuab mus rau 60 degree nyob rau hauv reflux. Rau qhov no tau ntxiv cov tshuaj npaj los ntawm embonic acid (388 g), sodium hydroxide (80 g) thiab dej (5 litres), tag nrho cov refluxed rau 10 feeb thiab tom qab ntawd tso cai rau txias thaum hmo ntuj. Cov txiaj ntsig embonate (530 g) tau lim tawm, ntxuav ob zaug nrog kev daws ntawm acetone (75 ml) hauv dej (425 ml), thiab ziab ntawm 100 degree kom muab cov hmoov daj amorphous, MP 290 degree rau 291 degree (nrog decomp .). 588 g ntawm embonate yog yaj nyob rau hauv boiling dej (4 litres). Hydrobromic acid 50% w / w (325 g) diluted nrog dej (2 liters) yog ntxiv maj mam ntawm lub boil thiab lub precipitated embonic acid tshem tawm los ntawm lim kub thiab ntxuav ob zaug nrog dej kub (1 liter). Cov filtrate thiab ntxuav tau evaporated rau dryness nyob rau hauv ib lub lauj kaub thiab cov residue recrystallized los ntawm ethyl cawv (1,200 ml), kom yield dibromide (320 g). |
| Kev kho mob muaj nuj nqi | Antihypertensive |
| Biochem/physiol Actions | Hexamethonium bromide yog nicotinic acetylcholine receptor (nAChR) antagonist. Nws zoo dua thaiv cov nicotinic receptors ntawm autonomic ganglia. Nws tuaj yeem hla cov ntshav-hlwb barrier nkaus xwb ntawm cov koob tshuaj ntau. |
| HEXAMETHONIUM BROMIDE Kev Npaj Khoom Thiab Cov Khoom Siv |
| Cov khoom nyoos | Ethanol-->Ethyl acetate-->Hydrogen bromide-->Calcium hydroxide-->Trimethylamine-->1,6-Hexanediol-->Trimethylamine hydrochloride-->1,6-Dibromohexane-->Dimethyl sulfate-->Sodium hydroxide-->Hexamethylenediamine |
Cim npe nrov: Tuam Tshoj hexamethonium bromide manufacturers, lwm tus neeg, Hoobkas
Tug: Propoxyethylene
Tom ntej: Diisopropylamine
Koj Tseem Yuav Zoo Li
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