Khoom

Diisopropylamine

Khoom Taw qhia

Diisopropylamine Cov ntaub ntawv yooj yim

Khoom npe:	Diisopropylamine
Synonyms:	Bis(isopropyl)amine;Diisopropylamin;dipropylamine(non-specificname);N-(1-Methylethyl)-2-propamine;n-(1-methylethyl)-2-propanamin;DiisopropylaMine, >99.5% (GC); N, N-Disopropylamine; N-Isopropyl-1-amino-2-methylethane
CAS:	108-18-9
MF:	C6H15N
MW:	101.19
EINECS:	203-558-5
Khoom Categories:	Pyrazoles, Pyrazines; Heterocyclic Compounds; Pharmaceutical Intermediates; bc0001
Mol File:	108-18-9.mol

Diisopropylamine Chemical Properties

Melting point	-61 degree (lit.)
Boiling point	84 degree (lit.)
ceev	0.722 g/mL ntawm 25 degree (lit.)
vapor ceev	3.5 (vs huab cua)
vapor siab	50 hli Hg (20 degree)
Refractive Index	n20 / D 1.392 (lit.)
Fp	1.4 degree F
cia temp.	Khaws hauv qab +30 degree .
solubility	100g / L (20 degree)
pka ua	11.05 (ntawm 25 degree)
daim ntawv	Ua kua
xim	Ntshiab xim tsis muaj xim
tsw	Amine.
PH	11.8 (6g / l, H2O, 20 degree)
tawg txwv	1.1-7.1%(V)
Dej Solubility	100 g/L (20 ºC)
Merck	14,3196
BRN	605284
Kev txwv tsis pub dhau	NIOSH REL: TWA 5 ppm (20 mg/m³), IDLH 200 ppm; OSHA PEL: TWA 5 ppm; ACGIH TLV: TWA 5 ppm (tau txais).
Dielectric tsis tu ncua	3.04
Kev ruaj ntseg:	ruaj khov. Flamable. Incompatible nrog muaj zog oxidizing neeg sawv cev. Tej zaum yuav hnov mob hnyav nrog cov kua qaub lossis oxidizers. Huab cua rhiab heev.
InChIKey	UAOMVDZJSHZZME-UHFFFAOYSA-N
LogP	0.4 ntawm 20 degree
CAS DataBase Reference	108-18-9(CAS DataBase Reference)
NIST Chemistry Reference	2-Propanamine, N-({2}}methylethyl)-(108-18-9)
EPA Tshuaj Registry System	Diisopropylamine (108-18-9)

Cov ntaub ntawv kev nyab xeeb

Hazard Codes	F,C
Risk Statements	11-20/22-34
Cov lus hais txog kev nyab xeeb	16-26-36/37/39-45
OEB	A
OEL	TWA: 5 ppm (20 mg/m3) [skin]
RIDADR	UN 1158 3/PG 2
WGK Germany	2
RTECS	IB 4025000
Autoignition Kub	599 degree F
Ceeb toom	Highly Flammable / Corrosive / Harmful
TSCA	Yog lawm
HS Code	2921 19 99
HazardClass	3
PackingGroup	II
Cov Ntaub Ntawv Muaj Xwm Ceev	108-18-9(Cov ntaub ntawv muaj phom sij)
Toxicity	LD50 qhov ncauj hauv nas: 0.77 g/kg (Smyth)
IDLA	200 ppm

MSDS Cov Ntaub Ntawv

Tus kws kho mob	Lus
Diisopropylamine	Lus Askiv
SigmaAldrich	Lus Askiv
ACROS	Lus Askiv
ALFA	Lus Askiv

Diisopropylamine Siv thiab Synthesis

Kev piav qhia	Diisopropylamine yog ib qho amine thib ob thiab yog cov kua tsis muaj xim ntawm chav tsev kub nrog cov ntses, zoo li ammonia tsw. Nws yog siv los ua tshuaj lom neeg nruab nrab, thiab catalyst rau kev sib txuas ntawm cov tshuaj tua kab thiab tshuaj. Diisopropylamine yog txuam nrog kev haus luam yeeb xws li ib yam khoom ntawm cov luam yeeb, cov khoom lag luam pyrolysis (hauv cov pa luam yeeb), los yog ntxiv rau ib lossis ntau hom khoom luam yeeb. Synonyms rau diisopropylamine muaj xws li DIPA, thiab N-(1-methylethyl)-2- propanamine.
Chemical Properties	Diisopropylamine yog flammable, muaj zog alkaline Colorless kua. Diisopropylamine yog soluble hauv dej thiab cawv. Cov ntxhiab tsw pib ntawm 0.017 txog 4.2 ppm; cov ntses zoo li tsw ua rau khaus ntawm 100 mg / m3.
Lub cev muaj zog	Cov kua tsis muaj xim nrog cov ntxhiab zoo li ammonia. Kev sim txiav txim kom pom thiab paub qhov tsw qhov pib qhov siab yog 50 ug / m³(130 Ib_v) thiab 190 ug / m³(380 Ib_v), raws li (Hellman and Small, 1974).
Siv	Diisopropylamine yog siv los ua tus thawj coj los npaj lithium diisopropylamide thiab sulfenamides, uas yog siv hauv roj hmab vulcanization. Nws kuj tseem koom nrog hauv kev sib txuas ntawm N, N-Disopropylethylamine (Hünig lub hauv paus) tau los ntawm alkylation nrog diethyl sulfate. Diisopropylammonium bromide yog bromide ntsev ntawm DIPA siv los ua lwm txoj hauv kev rau barium titanate. Nws yog dav siv raws li hnyav raws li ib tug intermediate nyob rau hauv lub synthesis ntawm pharmaceuticals, dyes, mineral flotation agents thiab emulsifiers.
Daim ntawv thov	Diisopropylamine yog siv los ua cov kuab tshuaj thiab hauv cov tshuaj synthesis ntawm dyes, pharmaceuticals, thiab lwm yam organic syntheses. Nws siv los ua ke diisopropylamine methyl urea (DMU), N, N-diisopropyl quinoline-2-carboxamide, 3-N-sulfonylamidine coumarins thiab N-chloroamine, ib qho nruab nrab los tsim amides.
Kev npaj	Diisopropylamine yog tsim los ntawm cov tshuaj tiv thaiv ntawm diisopropyl cawv nrog ammonia. Diisopropylamine kuj tseem tuaj yeem npaj los ntawm kev txo qis ntawm acetone nrog ammonia siv cov hloov pauv tooj liab oxide, feem ntau tooj liab chromite, ua ib qho catalyst: NH3+2(CH3)2CO+2H2 → C6H15N+2H2O
Kev piav qhia dav dav	Diisopropylamine zoo li cov kua ntshiab tsis muaj xim nrog cov ntxhiab tsw zoo li ammonia. Flash point 30 degree F. Tsawg ntom dua dej. Vapors hnyav dua li huab cua. Toxic oxides ntawm nitrogen ua thaum combustion. Siv los ua lwm yam tshuaj.
Cua & Dej Reactions	Cov nplaim taws heev. Soluble hauv dej. Sensitive rau cua sov thiab cua.
Reactivity Profile	Diisopropylamine tuaj yeem hnov mob hnyav nrog cov tshuaj oxidizing thiab cov kua qaub muaj zog. Yooj yim eutralizes acids hauv exothermic cov tshuaj tiv thaiv los tsim cov ntsev ntxiv rau dej. Tej zaum yuav tsis sib haum nrog isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, thiab acid halides. Flammable gaseous hydrogen tuaj yeem tsim ua ke nrog cov neeg ua haujlwm txo qis, xws li hydrides.
Health Hazard	Cov qib tso cai ntawm diisopropylamine yuav tsum tsis txhob ua rau muaj kev phom sij rau kev noj qab haus huv thiab kev noj qab haus huv. Kev nqus pa ntawm diisopropylamine tuaj yeem ua rau mob caj pas, hnoos, kub hnyiab thiab ua tsis taus pa. Cov teebmeem tshwm sim feem ntau tshwm sim nyob rau sab sauv ua pa, txawm tias tom qab kis tau ntev. Tsis muaj pov thawj tseeb tias diisopropylamine ua rau mob qog noj ntshav yog li tus nqi mob qog noj ntshav tsis tau tsim. Diisopropylamine tsis tau raug cais raws li qhov ua rau mob qog noj ntshav los ntawm Lub Chaw Haujlwm Saib Xyuas Kev Tshawb Fawb Thoob Ntiaj Teb rau Cancer, Tebchaws Meskas Lub Chaw Tiv Thaiv Ib puag ncig, Asmeskas Lub Rooj Sab Laj ntawm Cov Kws Kho Mob, lossis National Toxicology Program.
Health Hazard	Hauv tib neeg, diisopropylamine yog qhov muag khaus. Thaum raug cov concentration ntawm 25 thiab 50 ppm, cov neeg ua haujlwm yws yws ntawm qhov tsis pom kev. Kuj muaj kev tsis txaus siab ntawm xeev siab thiab mob taub hau. Cov kab mob dermatitis yuav xav tau los ntawm cov tawv nqaij ntev ntev (Beard and Noe, 1981).
Tshuaj Reactivity	Reactivity nrog dej Tsis muaj tshuaj tiv thaiv; Reactivity nrog cov khoom siv: Tej zaum yuav tawm tsam qee yam ntawm cov yas; Kev ruaj ntseg thaum thauj: ruaj khov; Neutralizing Agents rau Acids thiab Caustics: Tsis cuam tshuam; Polymerization: Tsis cuam tshuam; Inhibitor ntawm Polymerization: Tsis cuam tshuam.
Kev siv tshuab	Diisopropylamine yog siv los ua ib qho catalyst thiab ua tus stabilizer rau mesityl oxide (HSDB 1989). Nws kuj yog siv los ua ib qho nruab nrab hauv kev sib txuas ntawm cov dyes, tshuaj thiab tshuaj tua kab (xws li Diallate, Fenamiphos thiab Triallate).
Kev ruaj ntseg Profile	Muaj tshuaj lom los ntawm kev noj tshuaj thiab subcutaneous txoj hauv kev. Mob me me los ntawm kev nqus pa. Cov ntaub ntawv hloov pauv tau tshaj tawm. Ib daim tawv nqaij thiab qhov muag heev irritant. Kev nqus pa tuaj yeem ua rau pulmonary edema. Qhov phom sij txaus ntshai heev thaum raug tshav kub lossis nplaim taws; tuaj yeem cuam tshuam nrog cov khoom siv oxidizing. Txhawm rau tua hluav taws, siv cawv ua npuas ncauj, ua npuas ncauj, CO2, tshuaj qhuav. Thaum rhuab mus decomposition nws emits cov pa phem ntawm NOx Saib kuj AMINES.
Ntxim yuav nphav raug	Mutagen. Cov khoom no yog siv rau hauv kev npaj ntawm vapor-phase inhibitors thiab roj hmab accelerators; raws li cov tshuaj nruab nrab hauv kev sib xyaw ntawm cov tshuaj thiab tshuaj tua kab (diallate, fenamiphos, thiab triallate, piv txwv li).
Kev pab thawj zaug	Yog hais tias cov tshuaj no nkag mus rau hauv lub qhov muag, tshem tawm ib qho kev sib cuag lo ntsiab muag ib zaug thiab irrigate tam sim ntawd rau tsawg kawg yog 15 feeb, qee zaus nqa lub hau sab sauv thiab qis dua. Nrhiav kev kho mob tam sim ntawd. Yog tias cov tshuaj no cuam tshuam rau ntawm daim tawv nqaij, tshem cov khaub ncaws tsis huv thiab ntxuav tam sim nrog xab npum thiab dej. Nrhiav kev kho mob tam sim ntawd. Yog tias cov tshuaj no tau nqus tau, tshem tawm ntawm qhov raug, pib ua pa (siv kev ceev faj thoob ntiaj teb, suav nrog daim npog ntsej muag) yog tias ua pa tau nres thiab CPR yog tias lub plawv nres. Hloov tam sim ntawd mus rau qhov chaw kho mob.Thaum cov tshuaj no tau nqos lawm, mus ntsib kws kho mob. Muab dej ntau thiab ua kom ntuav. Tsis txhob ua rau tus neeg tsis nco qab ntuav. Kev soj ntsuam kho mob tau pom zoo rau 24-48 h tom qab ua pa ntau dhau, vim tias pulmonary edema yuav ncua sijhawm. Raws li kev pab thawj zaug rau pulmonary edema, kws kho mob lossis kws kho mob tau tso cai yuav txiav txim siab siv tshuaj corticosteroid.
Environmental txoj hmoo	Photolytic.Low et al. (1991) qhia tias photooxidation ntawm aqueous theem nrab amine daws los ntawm UV teeb nyob rau hauv lub xub ntiag ntawm titanium dioxide tshwm sim nyob rau hauv lub tsim ntawm ammonium thiab nitrate ions. Tshuaj / Lub cev.Reacts nrog acids tsim cov dej-soluble ntsev.
Metabolism	Me me, yog tias ib qho kev tshawb nrhiav ntawm cov metabolism ntawm luv-chain aliphatic amines tau raug tshaj tawm thiab qhov zoo tshaj plaws uas tuaj yeem ua tau yog qhia qee txoj hauv kev metabolic. Piv txwv li, flavin monooxygenase system tuaj yeem tsim cov hydroxylamine los ntawm N-hydroxylation catalyzed los ntawm flavin monooxygenase system (Ziegler 1988). N-hydroxylation tuaj yeem raug ntxias nrog cytochrome P-450 system raws li N-dealkylation cov tshuaj tiv thaiv (Lindeke thiab Cho 1982). Kev txheeb xyuas meej ntxiv yuav tsum tos cov kev tshawb fawb sim.
khaws cia	Xim Code-Red: Flammability Hazard: Khaws rau hauv qhov chaw cia cov kua hluav taws xob los yog lub txee tso cai kom deb ntawm qhov hluav taws kub thiab cov khoom siv corrosive thiab reactive. Ua ntej ua hauj lwm nrog DIPA koj yuav tsum tau kawm txog nws txoj kev tuav thiab khaws cia. Ua ntej nkag mus rau qhov chaw kaw qhov chaw uas cov tshuaj no tuaj yeem tshwm sim, xyuas kom paub tseeb tias tsis muaj cov khoom tawg tsis muaj nyob. Diisopropylamine yuav tsum tau muab khaws cia kom tsis txhob muaj cov kua qaub (xws li hydrochloric, sulfuric, thiab nitric) oroxidizers (xws li perchlorates, peroxides, permanganates, chlorates, thiab nitrates) vim muaj kev kub ntxhov tshwm sim. Khaws rau hauv cov thawv kaw nruj nreem rau hauv qhov chaw txias, zoo-ventilatedarea kom deb ntawm tshav kub. Qhov chaw ntawm qhov hluav taws kub, xws li haus luam yeeb thiab qhib nplaim taws, yog txwv tsis pub qhov twg diisopropylamine siv, tuav, lossis khaws cia hauv ib qho uas tuaj yeem tsim hluav taws kub lossis tawg puas tsuaj. Cov thawv hlau uas muaj kev hloov pauv ntawm =gallons lossis ntau dua ntawm diisopropylamine yuav tsum tau muab tso rau hauv av thiab sib txuas. Drums yuav tsum tau nruab nrog tus kheej-kaw li qub, lub tshuab nqus tsev bungs, thiab flamearresters. Siv cov cuab yeej thiab cov khoom siv uas tsis muaj hluav taws xob, tshwj xeeb tshaj yog thaum qhib thiab kaw cov ntim ntawm diisopropylamine.
Kev xa khoom	Qhov sib xyaw no xav tau daim ntawv xa khoom ntawm "FLAMMABLE LIQUID, CORROSIVE." Nws poob rau hauv Hazard Class 3 thiab Packing Group II.
Txoj Kev Purification	Distil cov amine los ntawm NaOH, los yog reflux nws peb feeb dhau Na hlau los yog NaH, thiab distil nws mus rau hauv ib tug qhuav receiver nyob rau hauv N2. [Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]
Kev tsis sib haum xeeb	Cov ntaub ntawv tawg sib xyaw nrog cua. Cov tshuaj no yog lub hauv paus muaj zog; reacts hnyav nrog cov muaj zog oxidizers, muaj zog acids. Tawm tsam tooj liab, zinc thiab lawv cov alloys, aluminium, thiab galvanized steel. Tawm tsam qee yam ntawm cov yas thiab txheej txheej.

Diisopropylamine Kev Npaj Cov Khoom Siv Thiab Cov Khoom Raw

Cov khoom nyoos

Ammonia-->Isopropyl alcohol-->Hydrogen-->Isopropylamine-->KAOLIN

Cov khoom npaj

1-Boc-4-methylpiperidine-4-carboxylic acid-->1-(2-ISOCYANO-ETHYL)-4-METHYL-PIPERAZINE-->5-AMINO-2-METHOXY-3-PICOLINE-->1,2-BIS(4-PYRIDYL)ETHANE-->4-(Trifluoromethyl)nicotinic acid-->2-Fluoro-6-formylpyridine-->1-(3,4-DICHLOROBENZYL)PIPERAZINE-->2-Chloro-6-trifluoromethylnicotinic acid-->2-Chloro-4-iodopyridine-3-carboxaldehyde-->4-Pyridyl acetone-->2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol-->1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID-->5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE-->2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID-->4-BROMO-5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-->4-Chloropyridine-3-carboxaldehyde-->2-Fluoro-5-iodobenzaldehyde-->2-Chloronicotinic acid-->2-methylhexanoic acid-->Eflornithine-->DIBENZYL DIISOPROPYLPHOSPHORAMIDITE-->2-(Tributylstannyl)pyrimidine-->3-Amino-5-phenylpyrazole-->2,5-DICHLORO-4-FORMYLPYRIDINE-->N,N-DIISOPROPYLBENZOTHIAZOLE-2-SULFENAMIDE-->3-BROMO-4-FORMYLPYRIDINE-->3-FLUOROPYRIDINE-4-BORONIC ACID-->4-AMINO-2-BUTANOL-->BIS(DIISOPROPYLAMINO)CHLOROPHOSPHINE-->1-Boc-piperazine acetate-->3,4-Dichloropyridine-->2-Bromo-6-fluorobenzoic acid-->3-Chloro-4-pyridineboronic acid hydrate-->Triallate-->3,4-DIBROMO-5-HYDROXY-5H-FURAN-2-ONE-->Creatinine-->DIALLATE-->2-Diisopropylaminoethanol-->dichlorodihydroxybis(isopropylamine)platinum-->Pinacidil

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